What is the chemical structure of 3-Bromo-N- {[4-methanesulfonyl-2- (trifluoromethyl) phenyl] methyl} pyridin-2-amine

This is the name of an organic compound. To deduce its chemical structure according to this name, it is necessary to analyze the meaning of each part in detail. "3 - Bromo - N - {[4 - methanesulfonyl - 2 - (trifluoromethyl) phenyl] methyl} pyridin - 2 - amine", "3 - Bromo" indicates that the third position of the pyridine ring has a bromine atom substitution; "pyridin - 2 - amine" indicates that the main structure of this compound is pyridine, and the second position is connected with an amino group; "N - {[4 - methanesulfonyl - 2 - (trifluoromethyl) phenyl] methyl}" indicates that the nitrogen atom is connected to a phenyl group containing a specific substituent.

Specifically, first look at the pyridine ring, which has an amino group at the 2nd position and a bromine atom at the 3rd position. Then look at the part connected to nitrogen, "[4-methanesulfonyl-2- (trifluoromethyl) phenyl] methyl", that is, the 4th position of the benzene ring has methanesulfonyl group (-SO < CH <), and the 2nd position has trifluoromethyl (-CF <). This benzene ring is connected to a methylene group, which is connected to the nitrogen atom of the amino group at the 2nd position of the pyridine ring.

In summary, the chemical structure of this compound is a pyridine ring as the core, with an amino group at the 2nd position and a bromine atom at the 3rd position. The nitrogen atom of the amino group is connected to a benzene ring through methylene, and the benzene ring is trifluoromethyl at the 2nd position and methylsulfonyl at the 4th position.

What are the main physical properties of 3-Bromo-N- {[4-methanesulfonyl-2- (trifluoromethyl) phenyl] methyl} pyridin-2-amine

3 - Bromo - N - {[4 - methanesulfonyl - 2 - (trifluoromethyl) phenyl] methyl} pyridin - 2 - amine is an organic compound. Its main physical properties are as follows:
- ** Appearance **: Usually presented in solid form, mostly white to white powder-like substances. This form is easy to store and handle. In most chemical reaction systems, powdered substances can increase the contact area with other reactants, which is conducive to efficient reaction.
- ** Melting point **: The transition from solid to liquid occurs at a specific temperature. The melting point data is of great significance for the purity identification of this compound and the distinction between it and other analogs. Due to different purity or structures of different compounds, the melting point is often different.
- ** Solubility **: It exhibits a certain solubility in organic solvents such as dichloromethane, N, N-dimethylformamide (DMF). Organic solvents can provide a homogeneous environment for chemical reactions, making the reactant molecules uniformly dispersed and promoting the smooth occurrence of the reaction. However, the compound has poor solubility in water, which is related to the existence of hydrophobic groups in its molecular structure, such as trifluoromethyl groups, which significantly reduce its affinity in water.
- ** Stability **: It has certain stability under conventional environmental conditions, but when it encounters strong oxidizing agents, strong acids or strong bases, chemical reactions may occur to cause structural changes. During storage and use, it is necessary to avoid contact with such substances. It is usually recommended to store in a cool, dry and well-ventilated place to ensure its chemical stability.

3-Bromo-N- {[4-methanesulfonyl-2- (trifluoromethyl) phenyl] methyl} pyridin-2-amine is used in what fields

3 - Bromo - N - {[4 - methanesulfonyl - 2 - (trifluoromethyl) phenyl] methyl} pyridin - 2 - amine is an organic compound. This compound may have unique applications in the field of pharmaceutical research and development. The specific functional groups contained in its structure, such as bromine atoms, pyridine amine groups, and phenyl groups containing trifluoromethyl and methanesulfonyl groups, give it the potential to interact with specific targets in vivo. Or it can be used as a lead compound, chemically modified and optimized for the development of new drugs, such as anti-tumor drugs. Due to its unique structure, it may interfere with specific signaling pathways of tumor cells and inhibit tumor growth and spread.

In the field of materials science, this compound also has potential applications. Its special structure may impart unique properties to materials. For example, in organic optoelectronic materials, or can adjust the electronic transport and optical properties of materials. The structural part containing trifluoromethyl can enhance the stability and hydrophobicity of materials, and help to improve the performance and stability of devices when preparing high-performance organic thin film transistors or organic Light Emitting Diodes.

In the field of pesticides, this compound may exhibit biological activity against certain pests or pathogens due to its structural properties. It can be used as the research and development basis for new pesticides to develop high-efficiency, low-toxicity and environmentally friendly pesticide products, which can help agricultural pest control. The combination of functional groups in its structure may specifically act on the specific physiological processes of pests or pathogens, achieving precise control.

3-Bromo-N- {[4-methanesulfonyl-2- (trifluoromethyl) phenyl] methyl} pyridin-2-amine

3 - Bromo - N - {[4 - methanesulfonyl - 2 - (trifluoromethyl) phenyl] methyl} pyridin - 2 - amine is an organic compound, and there are many synthesis methods. The following are some common methods:

First, 2 - amino - 3 - bromopyridine is used as the starting material. Shilling 2 - amino - 3 - bromopyridine is reacted with an appropriate protective reagent to protect the amino group from interference in subsequent reactions. After that, the protected product undergoes nucleophilic substitution reaction with halogenated hydrocarbons containing 4-methanesulfonyl-2 - (trifluoromethyl) benzyl structure under alkaline conditions. Commonly used bases include potassium carbonate, sodium carbonate, etc. The reaction solvent can be N, N-dimethylformamide (DMF), acetonitrile, etc. After the nucleophilic substitution reaction is completed, the protective group on the amino group is removed by appropriate deprotection reagents to obtain the target product 3-Bromo-N - {[4-methulfonyl-2 - (trifluoromethyl) phenyl] methyl} pyridin-2 - amine.

Second, 3-bromopyridine-2-carboxylic acid can also be used as the starting material. The 3-bromopyridine-2-carboxylic acid is first converted into the corresponding acid chloride, which is commonly used as a chlorination reagent such as dichlorosulfoxide. The resulting acid chloride is then reacted with 4-methylsulfonyl-2 - (trifluoromethyl) benzylamine to form an amide. This reaction is usually carried out in an inert solvent such as dichloromethane, and an organic base such as triethylamine is added to neutralize the generated hydrogen chloride. Then, the resulting amide is reduced, and a reducing agent such as lithium aluminum hydride can be selected to reduce the amide to the amine structure in the target product, and finally obtain 3-Bromo-N - {[4-methanesulfonyl-2 - (trifluoromethyl) phenyl] methyl} pyridin-2 -amine.

Third, a palladium-catalyzed coupling reaction strategy can also be used. Suzuki coupling reaction of 2-halo-3-bromopyridine (e.g. 2-iodine-3-bromopyridine) with 4-methylsulfonyl-2 - (trifluoromethyl) benzylboronic acid or its borate in the presence of palladium catalyst (e.g. tetrakis (triphenylphosphine) palladium, etc.), ligand and base. The reaction solvent can be selected as a mixed solvent of toluene, ethanol and water. The structure of the target product can also be effectively constructed by this method, and 3-Bromo-N - {[4-methanesulfonyl-2 - (trifluoromethyl) phenyl] methyl} pyridin-2-amine can be obtained.

The above methods have their own advantages and disadvantages. In the actual synthesis, the appropriate synthesis method should be carefully selected according to many factors such as the availability of raw materials, the difficulty of controlling the reaction conditions, and the purity requirements of the target product.

3-Bromo-N- {[4-methanesulfonyl-2- (trifluoromethyl) phenyl] methyl} pyridin-2-amine

There are currently 3 - Bromo - N - {[4 - methanesulfonyl - 2 - (trifluoromethyl) phenyl] methyl} pyridin - 2 - amine. The market prospect of this product needs to be carefully examined. Its way in pharmaceutical research and development may be promising. Due to its unique structure and potential biological activity, it can be used as a targeted drug lead compound, providing a new way to overcome difficult diseases, such as specific tumors and neurological diseases.

In the field of chemical synthesis, if the synthesis process can be refined, the raw materials are easily available and the cost is controllable, it will increase the market competitiveness. In materials science, it may be modified to give materials special properties, such as photoelectric properties, to open up new applications.

However, the market also has challenges. Synthesis steps are complicated, high costs, and large-scale production is restricted. And similar competitors, if they already occupy the market, need to have unique advantages if they want to stand out. Regulations and regulations require strict purity and safety requirements, and research and development must be compliant.

In summary, 3 - Bromo - N - {[4 - methanesulfonyl - 2 - (trifluoromethyl) phenyl] methyl} pyridin - 2 - amine has potential and also faces challenges. Practitioners can use their strengths and avoid weaknesses, refine their technology, operate in compliance, or gain a place in the market.