What is the main use of 3- (4-methyl-1H-imidazole-1-yl) -5- (trifluoromethyl) aniline?

3- (4-methyl-1H-pyrazole-1-yl) -5- (trifluoromethyl) pyridine, which has a wide range of uses.

In the field of medicinal chemistry, it can be used as a key intermediate. The structure of guinepyridine and pyrazole is common in many drug molecules and has unique biological activities. Based on this, a variety of compounds with specific pharmacological activities can be created after chemical modification and derivatization. For example, in the development of antimicrobial drugs, the substance may be modified to inhibit or kill certain bacteria, providing direction for the development of new antimicrobial drugs; in the exploration of anti-tumor drugs, through appropriate structural optimization, molecules that can target tumor cells may be obtained, enabling the birth of new anti-cancer drugs.

In the field of materials science, it also has potential applications. Pyridine and pyrazole structures give the compound specific electronic properties and spatial configuration. These properties can be exploited to introduce it into polymer materials to change the electrical, optical or mechanical properties of the material. For example, in the preparation of organic photovoltaic materials, the substance may participate in the construction of conjugated systems to improve the charge transport efficiency of materials, and then be used to manufacture photovoltaic devices such as organic Light Emitting Diodes (OLEDs) or organic solar cells with better performance.

In the field of pesticides, this compound may have insecticidal, bactericidal or herbicidal activities. Because of the presence of fluorine atoms in its structure, it can enhance the stability and fat solubility of the compound, which helps it penetrate the biofilm and reach the target. Or it can develop new pesticides with it as the core component, which can effectively prevent and control crop pests and diseases, and have relatively little impact on the environment, which is in line with the development trend of modern green pesticides.

What are the physical properties of 3- (4-methyl-1H-imidazole-1-yl) -5- (trifluoromethyl) aniline

3- (4-methyl-1H-pyrazole-1-yl) -5- (trifluoromethyl) pyridine, which is an organic compound. Its physical properties are rich and diverse:
In terms of appearance properties, it is often a crystalline solid, with white to off-white color, uniform and fine texture, and good stability under normal conditions, which is easy to observe and operate.
Melting point exists in a specific range, about [X] ℃ - [X] ℃. Melting point is a key physical constant, which is of great significance for its purity determination. If the purity of the material is extremely high, the melting point range is narrow and close to the theoretical value; if it contains impurities, the melting point is reduced and the range is wider. Therefore, the determination of the melting point can help to evaluate the purity of the compound. The boiling point of
also has a corresponding value, which is about [X] ° C. The boiling point is determined by the intermolecular forces of the compound, such as hydrogen bonds, van der Waals forces, etc. The intermolecular forces of this compound determine the energy required to transform from liquid to gaseous state. The boiling point value reflects its volatility. Under specific temperature conditions, it is very important to control the existence of its morphology and phase transition.
The solubility is unique and exhibits good solubility in organic solvents such as dichloromethane, N, N-dimethylformamide (DMF). This property is derived from the principle of "similar miscibility". The molecules of the compound are suitable for the intermolecular forces of the above organic solvents, which can achieve uniform dispersion at the molecular level. However, the solubility in water is not good, because the molecular polarity is quite different from that of water molecules, resulting in weak interaction and difficult to dissolve effectively. This solubility characteristic is crucial in the separation, purification and reaction medium selection of compounds. It can select suitable solvents according to the solubility characteristics to promote the smooth progress of related chemical reactions or achieve efficient product separation.

What are the chemical properties of 3- (4-methyl-1H-imidazole-1-yl) -5- (trifluoromethyl) aniline?

3- (4-methyl-1H-pyrazole-1-yl) -5- (trifluoromethyl) benzothiazole, the chemical properties of this compound are as follows:

From the structural point of view, the compound contains benzothiazole core skeleton, which is connected with a substituent containing pyrazolyl at 3 positions and trifluoromethyl at 5 positions. Benzothiazole compounds often have unique photoelectric properties and biological activities, and are widely used in the fields of materials science and medicinal chemistry.

In terms of physical properties, due to the strong electronegativity and electron absorption of trifluoromethyl, the molecular polarity changes, which affects its melting point, boiling point and solubility. In general, the introduction of trifluoromethyl can enhance the lipid solubility of compounds, and its solubility in organic solvents is good.

In terms of chemical activity, the nitrogen atom of pyrazolyl has a lone pair of electrons, which can be used as a hydrogen bond receptor or participate in coordination chemistry to form complexes with metal ions. This property may have applications in catalysis and materials. At the same time, the electron cloud distribution on the pyrazole ring allows electrophilic substitution reactions to occur at specific positions, such as halogenation and nitrification.

The presence of trifluoromethyl reduces the electron cloud density of ortho-carbon atoms, making it more difficult for nucleophiles to attack at this position. However, under appropriate conditions, trifluoromethyl can participate in reactions, such as trifluoromethylation reactions, and react with nucleophiles to form new fluorine-containing compounds. In addition, the benzothiazole ring can also participate in a variety of reactions, such as the substitution reaction on the ring, which can be structurally modified to meet different needs.

In summary, the special structure of 3- (4-methyl-1H-pyrazole-1-yl) -5- (trifluoromethyl) benzothiazoline shows a variety of chemical properties and has potential application value in many fields.

What are the synthesis methods of 3- (4-methyl-1H-imidazole-1-yl) -5- (trifluoromethyl) aniline?

To prepare 3- (4-methyl-1H-pyrazole-1-yl) -5- (trifluoromethyl) benzoic acid, the synthesis method is as follows:

The starting material can be selected from aromatic hydrocarbon derivatives containing appropriate substituents. First, by Fu-gram reaction, a specific substituent is introduced on the aromatic ring to construct a basic carbon skeleton structure. For example, a suitable halogenated aromatic hydrocarbon is reacted with the corresponding acyl halide under the catalysis of Lewis acid (such as anhydrous aluminum trichloride) to produce an intermediate with an acyl group. < Br >
Then, the resulting intermediate is reduced, and a suitable reducing agent, such as sodium borohydride or lithium aluminum hydride, can be used to convert the acyl group into an alcohol hydroxyl group. Next, a halogenating reagent, such as phosphorus tribromide or thionyl chloride, is used to convert the alcohol hydroxyl group into a halogen atom to obtain a halogenated aromatic derivative. After

, the halogenated aromatic hydrocarbon reacts with a nucleophile containing pyrazolyl through a nucleophilic substitution reaction. The preparation of pyrazolyl reagents can be obtained by condensation and cyclization of the corresponding amine compound with a carbonyl compound under appropriate conditions. In the nucleophilic substitution reaction, select a suitable base (such as potassium carbonate, sodium carbonate, etc.), and in a polar organic solvent (such as N, N-dimethylformamide, dimethylsulfoxide, etc.), promote the smooth progress of the reaction to form an aromatic hydrocarbon intermediate containing pyrazolyl.

Next, the trifluoromethylation reaction is carried out at another position on the aromatic ring. Trifluoromethylation reagents, such as sodium trifluoromethanesulfonate (CF 🥰 SO 🥰 Na), can be used to achieve the introduction of trifluoromethyl under the action of transition metal catalysts (such as copper salts, etc.).

Finally, the obtained intermediate is oxidized to oxidize the suitable substituent on the aromatic hydrocarbon ring to a carboxyl group, for example, using a strong oxidizing agent such as potassium permanganate, etc. Under appropriate reaction conditions, the target product 3- (4-methyl-1H-pyrazole-1-yl) -5- (trifluoromethyl) benzoic acid can be prepared. Pay attention to the control of reaction conditions at each step, including temperature, reaction time, proportion of reactants, etc., to improve the reaction yield and selectivity.

What is the market price range for 3- (4-methyl-1H-imidazole-1-yl) -5- (trifluoromethyl) aniline?

I don't know what "3-%284-%E7%94%B2%E5%9F%BA-1H-%E5%92%AA%E5%94%91-1-%E5%9F%BA%29-5-%28%E4%B8%89%E6%B0%9F%E7%94%B2%E5%9F%BA%29%E8%8B%AF%E8%83%BA" refers to. The symbols are strange and the semantics are difficult to understand. However, when it comes to the market price range, if there is no clear reference to the item, it is difficult to determine.

If you are talking about a certain herb or elixir, in the city, its price often varies according to quality, origin, supply and demand. For the top grade, the price must be high; for the bottom grade, the price is low. And for those whose origin is rare and difficult to collect, the price is not cheap. If there is a lot of demand for this item, but the supply is scarce, the price will rise; on the contrary, the supply exceeds the demand, and the price may trend down.

However, to know the exact price range, it is necessary to specify the characteristics and quality level of the item, and to observe the current market conditions, in order to obtain a more accurate number. The lack of information makes it difficult to determine the market price.