What is the main use of 3- [2- ({[4-methanesulfonyl-2- (trifluoromethyl) phenyl] methyl} amino) pyridin-3-yl] prop-2-yn1-ol

3 - [2 - ({[4-methanesulfonyl-2 - (trifluoromethyl) phenyl] methyl} amino) pyridine-3-yl] propylene-2-alkynes-1-ol, this compound may have important uses in the field of pharmaceutical research and development. In pharmaceutical chemistry, it is often used as a key intermediate to assist in the construction of new drug molecules. Due to its unique chemical structure, it contains active groups such as alkynyl, pyridine and specific substituted phenyl groups, which can participate in various chemical reactions and specifically bind to biological targets.

or can target some specific disease-related targets, such as specific kinases or receptors. By modifying and optimizing the structure of the compound and exploring its interaction mode with the target, it is hoped to obtain a lead compound with high activity, high selectivity and good safety, which will lay the foundation for innovative drug research and development. In the development of anti-tumor drugs, it may be able to act on key targets of tumor cell proliferation and apoptosis regulation by virtue of its structural characteristics, providing new ideas for solving tumor problems. In the development of drugs for neurological diseases, it may also play a role in the treatment of related diseases by modulating neurotransmitter-related targets.

What are the chemical properties of 3- [2- ({[4-methanesulfonyl-2- (trifluoromethyl) phenyl] methyl} amino) pyridin-3-yl] prop-2-yn1-ol

3 - [2 - ({[4-methanesulfonyl-2 - (trifluoromethyl) phenyl] methyl} amino) pyridine-3-yl] propylene-2-alkynes-1-ols, this compound has a variety of chemical properties. Its molecules contain alkynyl alcohol structures, alkynyl groups are active, and can participate in nucleophilic addition, such as forming carbon-carbon bonds with halogenated hydrocarbons under alkali catalysis to build complex structures. Hydroxyl groups can be substituted, esterified, and esters can be made with acyl chloride or acid anhydride for modification properties and construction of new compounds. Pyridine rings and nitrogen-containing heterocycles are basic, can form salts with acids, change solubility and stability, and pyridine rings can be attacked by electrophilic reagents and replaced by aromatic rings.

In this compound, 4-methanesulfonyl-2- (trifluoromethyl) phenyl moiety, methanesulfonyl has electron-absorbing properties, which affect electron cloud distribution and reactivity. Trifluoromethyl strongly absorbs electrons, increases lipophilicity, and has a great impact on biological activity and solubility. These structural characteristics make this compound have potential application value in the fields of organic synthesis and pharmaceutical chemistry, and can be used as an intermediate to synthesize compounds with specific biological activities or material properties.

What is the synthesis method of 3- [2- ({[4-methanesulfonyl-2- (trifluoromethyl) phenyl] methyl} amino) pyridin-3-yl] prop-2-yn- 1-ol

To prepare 3 - [2 - ({[4 - methanesulfonyl - 2 - (trifluoromethyl) phenyl] methyl} amino) pyridine - 3 - yl] propylene - 2 - alkyne - 1 - alcohol, the method is as follows:

First, 4 - methanesulfonyl - 2 - (trifluoromethyl) benzyl halide and 3 - amino - 2 - pyridyl alcohol should be prepared. Mix 4-methanesulfonyl-2- (trifluoromethyl) benzyl halide with a base, such as potassium carbonate, in a suitable organic solvent, such as acetonitrile. The effect of this base is to grab the active hydrogen around the halide to make it more reactive. Then, 3-amino-2-pyridyl alcohol is slowly added, and the temperature is raised to a moderate level, about 50-80 degrees Celsius, and the reaction is continuously stirred. In this reaction, the halogen atom of benzyl halide is substituted with the amino nucleophilic substitution of aminopyridine alcohol to gradually form the intermediate [2 - ({[4-methanesulfonyl-2 - (trifluoromethyl) phenyl] methyl} amino) pyridine-3 - alcohol.

Next, take this intermediate and place it again with an alkylene-propyl halide, such as propargyl bromide, in an organic solvent containing a base, such as N, N - dimethylformamide (DMF), with sodium hydride or cesium carbonate as a base, at room temperature or slightly higher temperature, such as 30 - 60 degrees Celsius, when the reaction number. At this time, the intermediate pyridyl alcohol hydroxyl oxygen nucleophilic attack propargyl halide halogen atom connected to the carbon, the halogen atom leaves, the final target product 3 - [2 - ({[4 -methanesulfonyl - 2 - (trifluoromethyl) phenyl] methyl} amino) pyridine - 3 - yl] propane - 2 - alkyne - 1 - alcohol. After the reaction is completed, the product is purified by extraction, column chromatography and other methods to achieve the desired purity.

Related Derivatives of 3- [2- ({[4-methanesulfonyl-2- (trifluoromethyl) phenyl] methyl} amino) pyridin-3-yl] prop-2-yn1-ol

3 - [2 - ({[4-methanesulfonyl-2 - (trifluoromethyl) phenyl] methyl} amino) pyridine-3-yl] propylene-2-alkyne-1-ol related derivatives are numerous. This compound contains unique structural units, and its alkynyl alcohol part can react with halogenated hydrocarbons or acyl halides through nucleophilic substitution reactions to generate alkynyl ether or alkynyl ester derivatives, which may have applications in organic synthesis and materials science. The amino group on the pyridine ring can participate in a variety of reactions due to the lone pair of electrons of the nitrogen atom, such as condensation with aldol and ketone to form Schiff base, or reaction with carboxylic acids and their derivatives to form amides, thereby deriving compounds containing different functional groups, which can be used as potential active ingredients in pharmaceutical chemistry. The methanesulfonyl group and trifluoromethyl group on the benzene ring affect the electron cloud distribution and lipophilicity of compounds. Based on this, by changing the type, position and quantity of benzene ring substituents, a series of structural analogs can be obtained to study the changes in their physical and chemical properties and biological activities. For example, adjusting the position of trifluoromethyl or replacing it with other fluorine-containing groups is expected to change the lipid solubility and metabolic stability of compounds, providing direction for the development of new drugs. At the same time, the synergistic modification of alkynyl alcohol, pyridyl amino and benzene ring parts may lead to the development of new functional materials or bioactive molecules with special properties.

What are the market prospects for 3- [2- ({[4-methanesulfonyl-2- (trifluoromethyl) phenyl] methyl} amino) pyridin-3-yl] prop-2-yn1-ol?

There is now a substance named 3- [2- ({[4-methanesulfonyl-2- (trifluoromethyl) phenyl] methyl} amino) pyridine-3-yl] propane-2-alkyne-1-ol. However, this substance is quite elusive in the market.

In various markets, this substance seems to be very common in circulation. Its structure is unique, and it contains groups such as methanesulfonyl and trifluoromethyl, so its synthesis may require exquisite methods, so it is rarely seen in ordinary trade. Due to its difficulty in preparation, rare raw materials, or its use is limited to a specific field, it is not widely used, and it is difficult to find its shadow in the market.

Although it is rare in the commercial market that is well known to the public, it may have its own influence in specific scientific research institutes and fine chemical research and development places. Cover because of its special structure, or it can be used to create new drugs and special effects materials. Scientists use it as a basis to explore unknown effects and develop new uses. Although it is rare in the market, it may have important value in niche fields of scientific research, which holds potential for future innovation and development.