What is the chemical structure of (2R) -6-fluoro-2- [ (2S) -oxiran-2-yl] -3, 4-dihydro-2H-1-benzopyran?

(2R) -6-fluoro-2- [ (2S) -ethylene oxide] -3,4-dihydro-2H-1-benzopyran, which is one of the organic compounds. Looking at its name, it can be seen that its structure contains a benzopyran parent nucleus, with (2S) -ethylene oxide at the 2nd position, a fluorine atom at the 6th position, and a dihydro state at the 3,4 positions.

Benzopyran is an oxygen-containing heterocycle with unique chemical activity. In this compound, its parent nucleus endows the overall specific stability and electron cloud distribution. The 2-position (2S) -ethylene oxide group, this ternary ring has a high tension, which makes it highly reactive, vulnerable to nucleophilic attack, initiating cyclization or nucleophilic substitution and other reactions. It is often a key check point in the field of organic synthesis. The 6-position fluorine atom, due to its high electronegativity, significantly affects the density and polarity of the molecular electron cloud, and can change the physical and chemical properties of the compound, such as lipophilicity, stability and biological activity. The double bond hydrogenation of the 3,4 positions forms a dihydrogen structure, which not only reduces the molecular unsaturation, but also affects its conjugate system, thereby affecting the spectral properties and reactivity of the compound. < Br >
The chemical structure of this compound integrates the characteristics of each part, and the interaction of each group creates unique chemical properties and potential applications, which may be of important research value in the fields of organic synthesis and medicinal chemistry.

What are the physical properties of (2R) -6-fluoro-2- [ (2S) -oxiran-2-yl] -3, 4-dihydro-2H-1-benzopyran?

(2R) -6-fluoro-2- [ (2S) -ethylene oxide] -3,4-dihydro-2H-1-benzopyran, having various physical properties. It is an organic compound that is mostly liquid at room temperature. Due to the moderate intermolecular force, it is neither strong enough to form a solid state nor weak enough to form a gaseous state. Looking at its color, it is usually colorless and transparent, pure state, no variegated interference, clear like water, because there are no chromogenic special groups in the molecular structure.

When it comes to odor, it is often weak and has a specific organic smell. It is neither pungent nor rich and fragrant, but only has a mild special taste, due to the chemical properties of the atoms and groups it contains. Its density is slightly higher than that of water, placed in water, and slowly sinks to the bottom, which is caused by the molecular mass and accumulation mode.

The solubility is quite unique, and it shows good mutual solubility in organic solvents such as ethanol and ether. Because of its molecular polarity, it is compatible with organic solvents, just like the combination of mortise and tenon, and can be evenly dispersed; its solubility in water is poor, because its structure is not highly hydrophilic, the force between water molecules and the compound molecules is difficult to match the compound's own molecular force, so it is difficult to dissolve. The melting point and boiling point also have their own characteristics. The melting point is relatively low, and a little heat is applied, that is, the solid state is converted to the liquid state; the boiling point is higher, and a considerable amount of heat is required to make its molecules break free from the liquid phase and transform into a gaseous state. This is closely related to factors such as intermolecular forces and hydrogen bonds.

What are the synthesis methods of (2R) -6-fluoro-2- [ (2S) -oxiran-2-yl] -3, 4-dihydro-2H-1-benzopyran?

The common methods for the synthesis of (2R) -6-fluoro-2- [ (2S) -ethylene oxide] -3,4-dihydro-2H-1-benzopyran are as follows.

First, the benzopyran skeleton is constructed by multi-step reaction with fluorine-containing benzene ring derivatives as starting materials. First, the benzopyran derivative and the enol ether compound with suitable substituents are nucleophilic addition reaction under specific catalyst and reaction conditions. This step requires precise regulation of reaction temperature and time to prevent side reactions from occurring. The addition product is then cyclized, often catalyzed by Lewis acid or protonic acid, to promote the formation of benzopyran structure in the molecule. Subsequently, through selective oxidation reaction, ethylene oxide groups are introduced at suitable positions. This process is crucial to the selection of oxidants and the control of reaction conditions, in order to achieve high stereoselectivity.

Second, there is also a method of semi-synthesis using natural products as starting materials. Natural benzopyran compounds with similar structures are selected, and fluorine atoms and ethylene oxide groups are introduced by chemical modification. First, specific functional groups of natural products are protected, and then fluorine atoms are introduced through halogenation reaction. The halogenation reagents and reaction conditions need to be carefully considered to achieve the required substitution position and selectivity. The ethylene oxide group is then formed by epoxidation reaction. The epoxidation reagent and reaction environment used in this step determine the selectivity of the ethylene oxide configuration.

Third, the coupling reaction catalyzed by transition metals can be used to efficiently synthesize the target compound. Appropriate halogenated benzopyran derivatives and nucleophiles containing ethylene oxide groups are selected, and carbon-carbon bonds or carbon-heteroatomic bonds are formed under the catalysis of transition metal catalysts such as palladium and nickel. In the reaction, the selection of ligands has a great influence on the catalytic activity and selectivity, and the pH and temperature of the reaction system also need to be precisely controlled to obtain high-purity (2R) -6-fluoro-2- [ (2S) -ethylene oxide] -3,4-dihydro-2H-1-benzopyran products.

(2R) -6-fluoro-2- [ (2S) -oxiran-2-yl] -3, 4-dihydro-2H-1-benzopyran in what fields?

(2R) -6-fluoro-2- [ (2S) -ethylene oxide] -3,4-dihydro-2H-1-benzopyran This compound has its uses in the fields of medicine and materials science.

In the field of medicine, due to its unique structure, or biological activity, it can interact with specific biological targets. Or it can be used to create new drugs, such as the treatment of certain diseases. Its ethylene oxide and benzopyran structures may give it the ability to penetrate biological membranes, and can precisely bind to protein receptors to regulate physiological processes. Or it can be developed into a therapeutic drug for inflammation, tumors and other diseases after in-depth research and modification.

In the field of materials science, this compound may be used as a synthetic raw material for functional materials. Its rigid benzopyran structure can provide stability and specific optical and electrical properties. Ethylene oxide groups are reactive and can participate in polymerization reactions, etc., to construct polymer materials with special structures and properties. Or smart materials with light response, self-healing and other properties can be prepared, which can be used in optical devices, sensors and other aspects.

In summary, (2R) -6-fluoro-2-[ (2S) -ethylene oxide] -3,4-dihydro-2H-1-benzopyran has potential value in pharmaceutical research and development and materials science innovation, and it is urgent for researchers to explore it in depth to explore more applications.

What is the market outlook for (2R) -6-fluoro-2- [ (2S) -oxiran-2-yl] -3, 4-dihydro-2H-1-benzopyran?

(2R) -6-fluoro-2- [ (2S) -ethylene oxide] -3,4-dihydro-2H-1-benzopyran, although not widely known, in the field of pharmaceutical and chemical industry, its prospects may be promising.

In today's market, there is a surge in new drug research and development, and the demand for compounds with unique structures and activities is increasing. ( 2R) -6-fluoro-2- [ (2S) -ethylene oxide] -3,4-dihydro-2H-1-benzopyran has a special molecular structure, which may provide an opportunity for innovative drug creation. In the exploration of anti-cancer drugs, such structures may be modified to target specific cancer cell pathways and exhibit anti-cancer activity. Therefore, in the frontier field of pharmaceutical research and development, it is expected to attract the attention of researchers and invest in research to explore its medicinal potential.

At the chemical synthesis level, although the synthesis process may be challenging, with the advancement of organic synthesis technology, new methods and new catalysts continue to emerge. If it can overcome its synthesis problems and achieve efficient and green synthesis, it will be able to reduce production costs and enhance product competitiveness. At that time, this compound may be like a pearl in the world, widely used in pharmaceutical production, bringing good news to patients.

Furthermore, with the advancement of analysis and detection technology, the purity and structure confirmation of (2R) -6-fluoro-2-[ (2S) -ethylene oxide] -3,4-dihydro-2H-1-benzopyran are more accurate and efficient, which can effectively promote it from the laboratory to industrial production, expand the market application space, and emerge in the future market, adding bricks and mortar to the pharmaceutical and chemical industry.