What is the main use of 2- (methylthio) -5- (trifluoromethyl) -1,3,4-thiadiazole?

2 - (methylthio) - 5 - (trifluoromethyl) - 1,3,4 -thiadiazole, this is an organic compound. It has a wide range of uses and is of great significance in many fields.

In the field of pesticides, it is often used as a fungicide. Due to its unique chemical structure, it can effectively inhibit the growth and reproduction of a variety of pathogenic bacteria. It can interact with specific biomacromolecules of pathogenic bacteria and interfere with their normal physiological and metabolic processes, such as affecting the respiration of pathogens, nucleic acid synthesis and other key links, and then achieve the effect of disease control, protecting the healthy growth of crops, and improving crop yield and quality.

In the field of medicine, it also shows potential medicinal value. Studies have shown that it has certain affinity and activity to some disease-related targets. It may be used as a lead compound, modified and optimized to develop new therapeutic drugs for the treatment of specific diseases and contribute to human health and well-being.

In the field of materials science, 2 - (methylthio) - 5 - (trifluoromethyl) - 1,3,4 - thiadiazole can be used as a functional monomer to participate in the synthesis of polymer materials. By introducing this monomer, it can endow materials with unique properties, such as improving material thermal stability, chemical stability and electrical properties, broadening the application range of materials and meeting the needs of different fields for special properties of materials.

In addition, in the field of organic synthesis, it is used as a key intermediate to construct more complex organic compound structures. With its activity check point, it can be combined with other organic reagents through various organic reactions, such as nucleophilic substitution and addition reactions, to prepare organic compounds with specific structures and functions, providing an important basis for the development of organic synthetic chemistry.

What are the synthesis methods of 2- (methylthio) -5- (trifluoromethyl) -1,3,4-thiadiazole

To prepare 2 - (methylthio) -5 - (trifluoromethyl) -1,3,4 -thiadiazole, there are many methods, and it is now common in you.

First, react with raw materials containing sulfur and nitrogen. For example, start with appropriate thioamides and halogens, and add bases, such as potassium carbonate, sodium carbonate, etc. to suitable solvents, such as dichloromethane, N, N-dimethylformamide, to promote its cyclization. The temperature and time of the reaction need to be carefully controlled. Generally, the temperature is between room temperature and 50 ° C, depending on the activity of the raw materials and the reaction process. The raw materials in this way are easy to purchase, and the operation is slightly simpler, but the yield may be affected by the purity of the raw materials and the reaction conditions.

Second, react with thiodiazole derivatives with trifluoromethylation reagents. Choose a trifluoromethylating agent with good activity, such as trifluoromethylsulfonyl chloride, etc., and react with a thiodiazole substrate under alkali catalysis in organic solvents such as toluene and acetonitrile. Base or use potassium tert-butyl alcohol, sodium hydride, etc., at a temperature of -20 ° C to room temperature, and the time is also time. This way can accurately introduce trifluoromethyl, but the trifluoromethylating agent is high in price and toxic, so it needs to be prevented.

Third, use transition metal catalysis. For example, metals such as palladium and copper are used as catalysts, biarylphosphine, etc. are used as ligands to promote the reaction of sulfur-containing substrates with trifluoromethylation reagents. In organic solvents such as dioxane, add alkali and heat at controlled temperature. The temperature may be 80-120 ° C, or 10-24 ° C. This method has the advantages of high efficiency and good selectivity, but the catalyst is expensive, the reaction conditions are harsh, and the post-treatment is complex.

All methods have advantages and disadvantages. To obtain high-purity and high-yield 2- (methylthio) -5 - (trifluoromethyl) -1,3,4-thiadiazole, it is necessary to select the appropriate method according to the actual situation, such as raw material source, cost, equipment, etc., and fine-tune the reaction conditions.

What are the physical properties of 2- (methylthio) -5- (trifluoromethyl) -1,3,4-thiadiazole

2 - (methylthio) - 5 - (trifluoromethyl) - 1,3,4 -thiadiazole, is one of the organic compounds. Its physical properties are unique, let me tell them one by one.

Looking at its appearance, under room temperature and pressure, it is mostly white to light yellow crystalline powder, just like fine jade chips, delicate and uniform. This color state is unique among many chemical substances, and is one of the important characteristics for identifying this substance.

Talking about the melting point, it is about 70-75 ° C. The melting point is the critical temperature at which the substance changes from solid to liquid. The melting point of this compound is in this range, which means that if it is slightly warmed, it can change its shape and gradually melt from the solid state to the liquid state, just like the spring snow meets the warm sun and quietly dissolves water.

Its boiling point data can reach about 250-260 ° C under specific pressure conditions. The significance of the boiling point is the temperature required for the transformation of a substance from a liquid state to a gaseous state. When the temperature rises to the boiling point, the compound evaporates like a cloud and dissolves into a gaseous state.

In terms of solubility, it exhibits different properties in organic solvents. In common organic solvents such as acetone and dichloromethane, it has good solubility, just like salt in water, which can be evenly dispersed to form a uniform solution; however, its solubility in water is very small, just like oil floating in water, it is difficult to blend, which is due to the difference between its molecular structure and that of water.

In addition, the density of this compound is also its important physical property. After determination, it is about 1.5-1.6 g/cm ³. The density is also the mass per unit volume of the substance. This value shows that under the same volume, compared with common substances such as water, 2 - (methylthio) - 5 - (trifluoromethyl) - 1,3,4 - thiadiazole is heavier in mass. In chemical production and related research, density data are of great significance for its storage and transportation.

What are the chemical properties of 2- (methylthio) -5- (trifluoromethyl) -1,3,4-thiadiazole

2 - (methylthio) - 5 - (trifluoromethyl) - 1,3,4 - thiadiazole, this is an organic compound. Its chemical properties are quite unique and show important value in many fields.

In terms of physical properties, this compound is usually in a solid state with a specific melting point and boiling point. However, the exact value will vary depending on the purity and measurement conditions. Its appearance may be white to light yellow crystalline powder, which exhibits some solubility in organic solvents. For example, it can be moderately dissolved in common organic solvents such as dichloromethane and chloroform, but its solubility in water is relatively poor.

Its chemical properties are active, and methylthio and trifluoromethyl give the compound unique reactivity. Sulfur atoms in methylthio groups are rich in solitary pair electrons, which can be used as nucleophiles to participate in many chemical reactions, such as nucleophilic substitution reactions. The strong electron-absorbing properties of trifluoromethyl groups significantly affect the distribution of molecular electron clouds, which reduce the density of electron clouds on the thiadiazole ring, thereby enhancing the electrophilicity of carbon atoms on the ring, which is easy to react with nucleophilic reagents.

2- (methylthio) -5- (trifluoromethyl) -1,3,4-thiadiazole can also participate in various types of chemical reactions. Under appropriate conditions, it can undergo substitution reactions with halogenated hydrocarbons. The sulfur atoms on methylthio groups attack the carbon atoms in halogenated hydrocarbons, and the halogen atoms leave to form new sulfur-containing compounds. At the same time, due to its nitrogen-containing heterocyclic structure, it can be used as a ligand to form complexes with metal ions, which may have potential applications in the field of catalysis. In addition, in some redox reactions, the compound may also exhibit unique chemical behaviors, or participate in the reaction as an oxidizing or reducing agent, depending on the properties of other reactants in the reaction system and reaction conditions.

What is the price of 2- (methylthio) -5- (trifluoromethyl) -1,3,4-thiadiazole in the market?

I look at your question, but I am inquiring about the price of 2 - (methylthio) -5 - (trifluoromethyl) -1,3,4 -thiadiazole in the market. However, the price of this product is difficult to determine.

The price of the cover is affected by many factors. First, the price of raw materials. If the price of methyl mercaptan, trifluoroacetic acid and other raw materials fluctuates, the price of 2 - (methylthio) -5 - (trifluoromethyl) -1,3,4 -thiadiazole will also change. If the raw material is harvested or the production capacity increases greatly, the price may drop; conversely, if the raw material is scarce or the production is reduced due to natural and man-made disasters, the price will rise. < Br >
Second, the preparation is difficult and easy. The preparation of this compound may require complicated steps, special reagents and conditions. If the preparation process is difficult, the equipment and technical requirements are high, the cost will increase, and the price will also be high. And if the new preparation method is developed, the process will be simplified, the cost will be reduced, and the price may also drop.

Third, market supply and demand. If many industries such as pesticides, pharmaceutical research and development have strong demand for it, but the supply is limited, the price will rise; if the demand is weak and the supply is excessive, the price will drop in order for merchants to sell their goods.

Fourth, the difference between regions. In different places, the price is also different due to differences in transportation costs, tax policies, market competition, etc. Prosperous commercial port, fierce competition, or low price; remote place, inconvenient transportation, cost plus, or high price.

Therefore, to know the exact price of 2- (methylthio) -5 - (trifluoromethyl) -1,3,4 -thiadiazole, it is necessary to carefully observe the raw material market, preparation process, supply and demand situation and regional factors, and often pay attention to chemical product trading platforms, industry information, or consult chemical raw material suppliers to obtain more accurate prices.