What is the chemical structure of 2-bromo-4 '-chloro-2' - (o-fluorobenzoyl) acetanilide?

2-Bromo-4 '-chloro-2' - (o-fluorobenzoyl) acetanilide is an organic compound. Looking at its name, it can be seen that the structure of this compound is quite characteristic.

In its structure, "acetanilide" (acetaniline) is the parent nucleus. For acetaniline, the benzene ring is connected to a nitrogen atom, and the nitrogen atom is connected to an acetyl group (-COCH).

In this compound, the nitrogen atom of the benzene ring is connected to the α-carbon atom of the acetyl group, which means "2-bromo".

"4 '-chloro" indicates that the benzene ring para-position (the carbon atom attached to nitrogen is No. 1, counted in order, and the para-position is No. 4) has a chlorine atom substitution.

"2' - (o-fluorobenzoyl) " means that an o-fluorobenzoyl group is connected to the ortho-position (position 2) of the nitrogen-linked benzene ring. This o-fluorobenzoyl group is connected to the ortho-position of the benzene ring with a fluorine atom, and the benzene ring is connected to the formyl group (-CO -), and the formyl group is then connected to the No. 2 carbon of the parent benzene ring.

In summary, the structure of this compound is derived from the parent nucleus of acetaniline, with the substitution of bromine, chlorine atom and o-fluorobenzoyl group at specific positions, thus forming a unique chemical structure.

What are the main physical properties of 2-bromo-4 '-chloro-2' - (o-fluorobenzoyl) acetanilide?

2-Bromo-4 '-chloro-2' - (o-fluorobenzoyl) acetanilide is an organic compound with unique physical properties. It is mostly solid at room temperature and has high stability due to the stable chemical bonds between atoms in the molecule.

Looking at its melting point, the melting point of this compound is not low, about 160-165 ° C. The higher melting point is attributed to the existence of hydrogen bonds and van der Waals forces between molecules. The interaction of structural units such as benzene ring, amide group and halogen atom in the molecule results in close bonding between molecules. More energy is required to make the molecule break free from the lattice binding and turn from solid to liquid. < Br >
The solubility of the compound is discussed. The compound has a certain solubility in common organic solvents such as dichloromethane, chloroform, N, N-dimethylformamide (DMF). This is because these organic solvents can form dipole-dipole interactions with the molecules of the compound, which is conducive to molecular dispersion. However, its solubility in water is very small. Due to its limited molecular polarity, it is difficult to form effective hydrogen bonds with water molecules, and the hydrophobic benzene ring structure hinders its miscibility with water.

Furthermore, its density is higher than that of water, about 1.5-1.6 g/cm ³. The higher density is due to the presence of halogen atoms with relatively large atomic weight such as bromine, chlorine, and fluorine in the molecule, which increases the mass of the substance per unit volume.

In addition, under specific wavelength light irradiation or under heating and other conditions, some chemical bonds in the molecular structure may break or rearrange, exhibiting unique photochemical and thermochemical properties. This property makes it a key intermediate in the field of organic synthesis to participate in many reactions, laying the foundation for the construction of more complex organic molecular structures.

In what fields is 2-bromo-4 '-chloro-2' - (o-fluorobenzoyl) acetanilide used?

2-Bromo-4 '-chloro-2' - (o-fluorobenzoyl) acetaniline, this compound has applications in various fields such as medicine, pesticides and materials.

In the field of medicine, due to its unique chemical structure, it has potential biological activity. Or it can be modified to fit specific targets and used as a lead compound in the process of drug development. For example, for some inflammation-related targets, through structural modification and optimization, it may be possible to develop new anti-inflammatory drugs; or in the development of anti-tumor drugs, explore its impact on specific signaling pathways of tumor cells, laying the foundation for innovative anti-cancer drugs.

In the field of pesticides, it can play an important role. Due to its structural characteristics, it may exhibit inhibitory or killing activity against specific pests and pathogens. For example, for common fungal diseases of crops, it can be developed into a fungicide, which can precisely act on the specific physiological processes of pathogenic bacteria to inhibit their growth and reproduction, thereby protecting the health of crops and improving yield and quality.

In the field of materials, its application should not be underestimated. Because it contains specific functional groups, it can be used as a synthesis intermediate for functional materials. For example, in the synthesis of polymer materials, the introduction of this compound structure unit endows the material with special properties, such as improving the optical and electrical properties of the material, and is used to produce new photoelectric materials. It shows potential application value in the manufacturing of organic Light Emitting Diodes, solar cells and other devices.

In summary, 2-bromo-4 '-chloro-2' - (o-fluorobenzoyl) acetaniline has broad application prospects in many fields. With the deepening of research and technological development, it will contribute more possibilities to the innovation and development of various fields.

What are the synthesis methods of 2-bromo-4 '-chloro-2' - (o-fluorobenzoyl) acetanilide?

2-Bromo-4 '-chloro-2' - (o-fluorobenzoyl) acetanilide is an organic compound. There are many ways to synthesize this compound. The following are common synthesis paths:

The starting material is p-chloroaniline, which is reacted with acetic anhydride in a first order. This reaction can promote aminoacetylation to form p-chloroacetaniline. The reaction conditions in this step are mild. At a suitable temperature and in the presence of a catalyst, the acetylation reaction between the two can occur smoothly to form the target intermediate.

The obtained p-chloroacetaniline reacts with o-fluorobenzoyl chloride in the presence of a base. The role of the base is to neutralize the hydrogen chloride generated by the reaction and promote the positive progress of the reaction. In this reaction, the acyl group of o-fluorobenzoyl chloride undergoes electrophilic substitution with the benzene ring of p-chloroacetaniline to form 2- (o-fluorobenzoyl) -4 '-chloroacetanilide.

Subsequently, 2- (o-fluorobenzoyl) -4' -chloroacetanilide is reacted with a brominating reagent such as N-bromosuccinimide (NBS). NBS is a commonly used brominating agent. Under specific reaction conditions, it can selectively replace hydrogen atoms at specific positions on the benzene ring with bromine atoms, and finally generate 2-bromo-4 '-chloro-2' - (o-fluorobenzoyl) acetanilide.

In addition, there are other synthesis strategies. For example, the benzoyl moiety can be constructed first, and then the acetyl group and bromine atoms can be introduced; or different starting materials can be selected to achieve the construction of the target molecule through multi-step reactions. However, no matter what method, the reaction conditions, such as temperature, reaction time, ratio of reactants, and catalyst type and dosage, need to be carefully adjusted according to the reaction characteristics of each step, in order to achieve high yield and better selectivity. At the same time, effective separation and purification operations are required after each step of the reaction to obtain a pure product, which lays the foundation for subsequent reactions or applications.

What is the safety profile of 2-bromo-4 '-chloro-2' - (o-fluorobenzoyl) acetanilide?

2-Bromo-4 '-chloro-2' - (o-fluorobenzoyl) acetanilide is an organic compound. Its safety is related to many factors, which are detailed as follows:
First, toxicity. This compound contains halogen atoms such as bromine, chlorine, and fluorine, or has certain toxicity. If people are inadvertently exposed, it can be absorbed through the skin, inhaled, or ingested by mistake, or damage health. As evidenced by animal experiments, halogen-containing organic compounds can often cause liver, kidney and other organs damage, and may have potential genotoxicity and carcinogenicity. Although there are no detailed human studies on this specific compound, its toxicity should not be underestimated according to the characteristics of similar structural compounds.
Second, environmental impact. In the environment, this compound is difficult to degrade due to its structure containing stable groups such as benzene rings and acyl groups. If it flows into water, soil, or remains for a long time, it will affect the ecology. For aquatic organisms, it may cause their growth, reproduction to be inhibited, and even die. And may be transmitted and enriched through the food chain, endangering more advanced organisms.
Third, the risk of ignition and explosion. From the perspective of chemical structure, it is atypical flammable and explosive. In case of hot topics, open flames, or contact with strong oxidants, or chemical reactions, there is a risk of combustion and explosion. Because organic compounds under specific conditions, or decompose to produce flammable and toxic gases.
Fourth, operational safety. In laboratory or industrial production operations, due to potential toxicity and chemical activity, improper operation, such as not following the standard use of protective equipment, mixing or storage according to the process, can cause danger. For example, mixing with incompatible chemicals, or causing severe reactions.
In summary, 2-bromo-4 '-chloro-2' - (o-fluorobenzoyl) acetanilide has certain safety hazards. Whether it is experimental research or industrial application, it needs to be treated with caution, strictly follow safety procedures, and do a good job of protection and environmental monitoring to reduce its harm to people and the environment.