What is the chemical structure of 2-Amino-N- (2,2,2-trifluoroethyl) acetamide hydrochloride (1:1)?

This is a compound named "2-Amino-N- (2,2,2-trifluoroethyl) acetamide hydrochloride (1:1) ". Its chemical structure is analyzed as follows:

First look at its main acetamide part. Acetamide is a structural unit formed by the connection of acetyl groups (CH 🥰 CO -) and amino groups (-NH 🥰). This is the basic skeleton of the compound.

On the nitrogen atom of acetamide, there is a 2,2,2-trifluoroethyl group connected. In this trifluoroethyl group, all three hydrogen atoms of ethyl are replaced by fluorine atoms to form the structure of -CH 🥰 CF 🥰. The introduction of fluorine atoms, due to the high electronegativity of fluorine atoms, will significantly affect the electron cloud distribution and physical and chemical properties of molecules, such as enhancing the lipophilicity of molecules and changing molecular polarity.

Furthermore, this compound is a hydrochloride salt (1:1), which means that each 2-amino-N - (2,2,2-trifluoroethyl) acetamide molecule binds one molecule of hydrogen chloride. This is because the nitrogen atom of the amino group in the molecule has a lone pair of electrons, which can be combined with the hydrogen ion ionized from hydrogen chloride (H 🥰) through coordination bonds to form a cationic part, and the chloride ion (Cl) acts as an anion with an equilibrium charge to form an ionic compound. The formation of this hydrochloride can enhance the solubility of the compound in water, due to the strong interaction between ions and water molecules, that is, ion-dipole interaction.

In summary, the chemical structure of 2-amino-N - (2,2,2-trifluoroethyl) acetamide hydrochloride (1:1) fuses the characteristics of acetamide, trifluoroethyl and hydrochloride, and the interaction of each part endows the compound with unique chemical and physical properties.

What are the main uses of 2-Amino-N- (2,2,2-trifluoroethyl) acetamide hydrochloride (1:1)?

2-Amino-N - (2,2,2-trifluoroethyl) acetamide hydrochloride (1:1), this is an important chemical substance with a wide range of uses.

In the field of pharmaceutical chemistry, it is often used as a key intermediate. Because it contains a special trifluoroethyl structure, it gives unique chemical and physical properties, which is of great significance for drug development. With its structural properties, it may optimize the activity, stability and bioavailability of drug molecules. For example, when synthesizing new antiviral or anti-tumor drugs, the introduction of this structural unit may enhance the ability of the drug to bind to specific targets and improve the efficacy.

In the field of organic synthesis, it is also an indispensable raw material. Due to its functional groups, it can participate in many chemical reactions, such as amidation and substitution reactions. Chemists use this substance to build more complex organic molecular structures by ingeniously designing reaction paths, expanding the types and functions of organic compounds.

In the field of materials science, there are also potential uses. Due to its unique chemical structure, it may be used to prepare materials with special properties, such as fluoropolymer materials. Such materials may have excellent corrosion resistance, weather resistance and low surface energy, and have broad application prospects in aerospace, electronics and other industries.

Furthermore, in the field of agricultural chemistry, it may be used to develop new pesticides. Through structural modification and modification, high-efficiency, low-toxicity and environmentally friendly pesticide products have been developed to contribute to sustainable agricultural development.

In summary, 2-amino-N - (2,2,2-trifluoroethyl) acetamide hydrochloride (1:1) plays an important role in many fields and provides key support for the development of many industries.

What are the physical properties of 2-Amino-N- (2,2,2-trifluoroethyl) acetamide hydrochloride (1:1)?

2-Amino-N- (2,2,2-trifluoroethyl) acetamide hydrochloride (1:1) is an organic compound. Its physical properties are as follows:

Under normal temperature and pressure, it is mostly in the state of white to quasi-white crystalline powder. Due to the arrangement of atoms and groups in the molecular structure, its crystallization habit is like this, and the powder morphology is conducive to dispersion in many reaction systems.

When it comes to solubility, it has good solubility in water. The cap is easily soluble in water because it contains polar groups such as amino and amide groups in its molecules, which can interact with water molecules through hydrogen bonds. However, in non-polar solvents such as ether, the solubility is poor. Due to the difference between polar and non-polar solvents, the interaction between the two is weak.

Melting point is also one of its important physical properties. This compound has a specific melting point range. When heated to a certain temperature, the molecule obtains enough energy, and the lattice structure begins to disintegrate, resulting in a phase transition. The exact melting point value depends on factors such as the purity of the compound, but it is usually within a specific range. This melting point characteristic can be used to identify and purify the compound. < Br >
Its density is also an inherent physical property. Although it fluctuates slightly due to measurement conditions, it has a relatively fixed value under specific conditions. This value is of great significance for considering its dispersion and mixing in different media.

In addition, the stability of this compound also belongs to the category of physical properties. It is relatively stable in a dry environment at room temperature; when exposed to high temperature, high humidity or specific chemical substances, chemical reactions may occur, causing changes in its structure and properties. This stability is derived from the strength of the chemical bonds within the molecule and the stability of the spatial structure. In conclusion, the physical properties of 2-amino-N - (2,2,2-trifluoroethyl) acetamide hydrochloride (1:1) are determined by its molecular structure, and have far-reaching impact on its applications in chemical and pharmaceutical fields.

What are the synthesis methods of 2-Amino-N- (2,2,2-trifluoroethyl) acetamide hydrochloride (1:1)?

The synthesis method of 2-amino-N- (2,2,2-trifluoroethyl) acetamide hydrochloride (1:1) has been around for a long time. In the past, Xian Da, in the field of chemical synthesis, worked hard and accumulated a lot of experience.

One method is to use fluorine-containing starting materials to first undergo a halogenation reaction to introduce fluorine atoms into halogen atoms. This halogen atom is active and can undergo nucleophilic substitution with acetamide derivatives. During the reaction, the solvent needs to be carefully selected to promote the smooth progress of the reaction. For example, dimethylformamide (DMF) has good polarity and can dissolve many reactants, making the reaction uniform and efficient. In this solvent, the temperature and reaction time are controlled to make the nucleophilic substitution reaction proceed steadily to obtain the target product precursor.

After that, the precursor is reacted with hydrochloric acid to form 2-amino-N - (2,2,2-trifluoroethyl) acetamide hydrochloride (1:1). In this reaction, attention should also be paid to the concentration and dosage of hydrochloric acid. If there is too much or too little hydrochloric acid, the purity and yield of the product can be affected. Temperature regulation is also crucial. If it is too high, the product may decompose, and if it is too low, the reaction will be delayed.

Another method is to use trifluoroethanol as the starting material, first convert it into the corresponding halogen, and then react with aminoacetamide. At the time of reaction, an appropriate base can be selected to neutralize the generated hydrogen halide, causing the reaction equilibrium to shift to the right. Such as potassium carbonate, the alkalinity is moderate, and the solubility in common organic solvents is acceptable.

After the reaction is completed, the separation and purification of the product is also critical. The method of recrystallization is often used to select a suitable solvent, so that the solubility of the product in it varies significantly with temperature. Cooling the hot saturated solution, the product precipitates, and the impurities remain in the mother liquor, so that a high purity of 2-amino-N - (2,2,2-trifluoroethyl) acetamide hydrochloride (1:1) can be obtained. There is also a method of column chromatography, which uses the difference in the adsorption capacity of the adsorbent to separate the product from the impurities to achieve the purpose of purification.

2-Amino-N- (2,2,2-trifluoroethyl) acetamide hydrochloride (1:1) What are the precautions during storage and transportation?

2-Amino-N - (2,2,2-trifluoroethyl) acetamide hydrochloride (1:1) is a chemical substance. When storing and transporting, there are several ends that should be added.

First storage environment. Must be placed in a cool, dry and well-ventilated place, away from direct sunlight. Cover light or cause its chemical properties to deteriorate, damage its quality. And this substance may be sensitive to humidity, too high humidity, or the risk of deliquescence, so it should be controlled to be wet and should be stored in a low relative humidity environment.

Second words packaging. It needs to be stored in a well-sealed container. The seal can prevent external moisture, oxygen, etc. from contacting the substance. If the package is damaged, external factors can easily cause it to deteriorate. The selected packaging material must also be suitable, and it should not chemically react with the substance to ensure the integrity and sturdiness of the package, and avoid leakage during transportation.

Further transportation. Stabilize this object during transportation to avoid bumps and vibrations. Violent vibration may cause damage to the package, or cause internal chemical changes. The means of transportation should also be clean and dry, with no other chemical residues, to avoid cross-contamination.

Also, operation and contact. Storage and transportation personnel must wear appropriate protective equipment, such as gloves, goggles, etc. Because the substance may be irritating, direct contact with the skin and eyes may cause discomfort or injury. If it is inadvertently touched, it should be dealt with promptly according to the corresponding emergency rescue method.

In short, during the storage and transportation of 2-amino-N - (2,2,2-trifluoroethyl) acetamide hydrochloride (1:1), all details are related to its quality and safety. It is necessary to be cautious and follow the norms.