What is the chemical structure of 2-amino-6-fluoro-N-phenylbenzamide?

2-Amino-6-fluoro-N-phenylbenzamide, one of the organic compounds. To clarify its chemical structure, we need to analyze the meaning of its name in detail. "Benzamide" indicates that its core structure is benzamide, that is, a benzene ring is connected to a formamide group. "2-amino" indicates that there is an amino (-NH ²) substitution at position 2 of the benzene ring. "6-fluoro" refers to the fluorine atom (-F) at position 6 of the benzene ring. "N-phenyl" indicates that the nitrogen atom of the formamide group is connected to a benzene ring.

Take the phenyl ring as the group in the figure, with an amino group at the 2nd position and a fluorine atom at the 6th position. In the formamide group, one end of the carbonyl group (-C = O) is connected to the benzene ring, and the nitrogen atom is connected to the other benzene ring. In this structure, the benzene ring is aromatic, and the amino group, fluorine atom and formamide group all have important effects on its chemical properties. Amino groups can participate in a variety of nucleophilic reactions. The fluorine atom can change the electron cloud distribution of the molecule due to its high electronegativity, which affects the polarity and reactivity of the compound. Formamyl groups contain both carbonyl groups and nitrogen atoms, and can undergo reactions such as hydrolysis and condensation. In this way, the chemical structure of 2 - amino - 6 - fluoro - N - phenylbenzamide can be understood, and its structural characteristics also determine its potential applications in organic synthesis, pharmaceutical chemistry and other fields.

What are the physical properties of 2-amino-6-fluoro-N-phenylbenzamide?

2-Amino-6-fluoro-N-phenylbenzamide is an organic compound. To understand its physical properties, please consider the following details.

First of all, its appearance is often white to white-like crystalline powder. The formation of this state is due to the orderly arrangement formed by the interaction of its molecules, which makes its macroscopic morphology stable.

As for the melting point, it is about 145-148 ° C. The characteristics of the melting point depend on the strength of the intermolecular forces. In this compound, the interactions of hydrogen bonds and van der Waals forces between molecules reach equilibrium at a specific temperature, causing the solid state to transform into a liquid state. This specific temperature is the melting point. < Br >
Solubility is also an important physical property. It exhibits good solubility in organic solvents such as dichloromethane, N, N-dimethylformamide (DMF), etc. Because of this, the compound molecule and the organic solvent molecule can form a uniform and stable dispersion system through the principle of similar miscibility, van der Waals force, dipole-dipole interaction, etc. However, in water, its solubility is poor, due to the strong hydrogen bond network between water molecules, the interaction with the organic compound molecule is weak, and it is difficult to break the original structure between water molecules, so it is difficult to dissolve.

Furthermore, its density also has a fixed number. Although the exact value needs to be accurately determined by experiments, it is mainly determined by the molecular structure and relative molecular mass. The number and arrangement of atoms such as carbon, hydrogen, nitrogen, fluorine, and oxygen in a molecule determine its mass and space occupation, which in turn affects its density.

In addition, the stability of this compound is quite high at room temperature and pressure. The conjugate structure of the benzene ring in the molecule, as well as the existence of chemical bonds such as amide bonds, endow it with certain chemical stability. In case of extreme conditions such as strong acids, strong bases, or high temperatures, its chemical bonds may break or rearrange, resulting in structural changes and impaired stability.

Its refractive index is also one of the physical properties. The refractive index reflects the degree of refraction when light propagates in the substance, and is related to the distribution of electron clouds in molecules and the symmetry of molecular structures. Accurate determination of refractive index can provide a strong basis for the identification of this compound.

In summary, the physical properties of 2-amino-6-fluoro-N-phenylbenzamide, such as appearance, melting point, solubility, density, stability and refractive index, are determined by its molecular structure, and are of great significance in chemical research, drug development and other fields.

What are the main uses of 2-amino-6-fluoro-N-phenylbenzamide?

2-Amino-6-fluoro-N-phenylbenzamide, Chinese name 2-amino-6-fluoro-N-phenylbenzamide, is widely used in the field of medicine and is often used as a key intermediate for active pharmaceutical ingredients. It plays an important role in the development of many new antibacterial, anti-inflammatory and anti-tumor drugs. The structure of genobenzamide can tightly bind to specific biological targets, precisely regulate biochemical reactions in organisms, inhibit specific enzyme activities, or interfere with cell signaling pathways, and then achieve the purpose of treating diseases.

In the field of materials science, it also has extraordinary performance. It can participate in the synthesis of polymer materials and endow materials with unique properties. When preparing functional polymers, introducing them into the main chain or side chain of the polymer can improve the thermal stability, mechanical properties and optical properties of the material. Because of its fluorine atom and benzene ring structure, it can enhance the interaction between molecules and improve the overall properties of the material.

Furthermore, in the field of organic synthetic chemistry, 2-amino-6-fluoro-N-phenylbenzamide is an extremely important synthetic building block. With its unique molecular structure, complex organic molecular structures can be constructed through various chemical reactions, such as nucleophilic substitution, electrophilic substitution and cyclization reactions. This allows chemists to design and synthesize organic compounds with specific functions and structures, injecting new vitality into the development of organic synthetic chemistry and expanding possible paths for the development of new organic materials and drugs.

What are 2-amino-6-fluoro-N-phenylbenzamide synthesis methods?

The synthesis method of 2-amino-6-fluoro-N-phenylbenzamide has been around for a long time. In the past, there were many ways to make this substance.

First, it is based on 2-amino-6-fluorobenzoic acid, which is combined with benzoyl chloride in an appropriate solvent, supplemented by an acid binding agent, at room temperature or slightly hot, and the two then react with acylation to form 2-amino-6-fluoro-N-phenylbenzamide. During this journey, the solvent often takes dichloromethane, trichloromethane and the like, and the acid binding agents are mostly triethylamine and pyridine. When operating, pay attention to the temperature and time of the reaction. If the temperature is too high, there may be side reactions; if the time is too short, the reaction will not be fully functional.

Second, start with 6-fluorobenzoic acid. After nitration and reduction, 2-amino-6-fluorobenzoic acid is obtained, and then react with benzoyl chloride as before. During nitrification, the mixed acid of nitric acid and sulfuric acid is often used, and the reaction temperature needs to be carefully adjusted to prevent over-nitrification. During reduction, reducing agents such as iron powder and zinc powder can make nitro groups into amino groups in acidic media. The subsequent acylation reaction with benzoyl chloride should also be controlled according to the regulations of the previous law. < Br >
There are also those who use 2-chloro-6-fluorobenzoic acid as a raw material, which is first converted into an acid chloride, and then reacted with aniline under suitable conditions. Among them, the conversion of acid chloride is commonly used, and the reaction is more convenient. When reacting with aniline, the choice of solvent and acid binding agent also affects the yield and purity of the product.

All these methods have advantages and disadvantages. Fang family in the actual operation, when according to the raw materials, equipment, as well as the purity of the product, yield requirements, careful consideration, choose the best, in order to obtain the best effect, the 2-amino-6-fluoro-N-phenylbenzamide.

What is the price range of 2-amino-6-fluoro-N-phenylbenzamide in the market?

In today's world, business conditions are fickle, and it is not easy to determine the price range of 2-amino-6-fluoro-N-phenylbenzamide in the market. This chemical, whether used in scientific research experiments or as a pharmaceutical raw material, has different uses and prices.

Looking at the example of "Tiangong Kaiwu" in the past, which detailed the skills of hundreds of workers and various products, the prices at that time were very different from today. Today's market is influenced by many factors. The abundance of raw materials, the simplicity of craftsmanship, the amount of demand, and the situation of competition can all make prices fluctuate.

If we talk about this 2-amino-6-fluoro-N-phenylbenzamide, the difficulty of its synthesis is related to cost. If the required raw materials are scarce and rare, or the synthesis steps are complicated and the conditions are harsh, the cost will be high and the price will be high. Furthermore, if the market demand is strong, the supply is in short supply, and the price will also rise; conversely, the demand is low, the supply exceeds the demand, and the price will fall.

However, I have not personally involved in the chemical raw material trading market, so it is difficult to accurately describe its price range. It is generally necessary to consult merchants specializing in chemical products, check industry reports, or study carefully on relevant chemical trading platforms to obtain a more accurate price range, but it is only a temporary price that varies with the market.