What are the main uses of 2- (4-fluorophenyl) thiophene?

2-%284-fluorophenyl%29thiophene is 2 - (4 - fluorophenyl) thiophene, which has a wide range of uses. It is an important intermediate in the field of organic synthesis. Organic compounds with complex structures can be constructed through various chemical reactions. For example, when constructing materials with specific optoelectronic properties, 2 - (4 - fluorophenyl) thiophene can participate in the reaction to form a conjugated system with its unique molecular structure, which can significantly affect the photoelectric properties of the material.

In the field of materials science, it also plays a key role in the preparation of organic semiconductor materials. Organic semiconductor materials have attracted much attention in device applications such as organic Light Emitting Diodes (OLEDs) and organic field effect transistors (OFETs). 2 - (4 - fluorophenyl) thiophene can optimize the charge transport performance, carrier mobility and other key parameters of the material after rational chemical modification and processing, and improve the performance and efficiency of the device.

In the field of medicinal chemistry, due to the particularity of the structure of thiophene and fluorophenyl, 2 - (4 - fluorophenyl) thiophene may be used as a lead compound structural unit. Through structural modification and optimization, it is expected to develop new drugs with specific biological activities for the treatment of related diseases.

In addition, in the preparation of fine chemical products, 2- (4-fluorophenyl) thiophene can be used to synthesize additives and auxiliaries with special functions, giving the product unique properties to meet different industrial and consumer needs. In short, 2- (4-fluorophenyl) thiophene has shown important application value in many fields due to its unique structure, promoting the development and innovation of related fields.

What are the physical properties of 2- (4-fluorophenyl) thiophene?

The 2-% (4-fluorophenyl) thiophene is one of the organic compounds. Its physical properties are very important and related to its application in various fields.

First word appearance, this compound is often in a solid state, mostly white to light yellow powder or crystalline state, and its color and morphology vary slightly depending on the preparation method and purity.

Melting point is also a key physical property. The melting point of 2-% (4-fluorophenyl) thiophene is about a specific range. This temperature value is of great significance for its heating or melting-related operations. It can help determine its physical state transformation and control the temperature accordingly during material processing to ensure material properties.

In terms of solubility, it has a certain performance in organic solvents. Common organic solvents such as dichloromethane, chloroform, tetrahydrofuran, etc., have good solubility in this compound. This property is extremely useful in organic synthesis reactions, which can make the reactants uniformly disperse and promote the reaction. However, in water, its solubility is poor, and the interaction with water is weak because its structure contains hydrophobic groups.

Furthermore, its density also has a specific value. Density, as an inherent property of a substance, is indispensable in operations such as substance separation and measurement. Knowing its density, you can accurately measure a certain mass or volume of the compound to ensure the accuracy of the experiment or production process.

In addition, 2-% (4-fluorophenyl) thiophene is volatile to a certain extent. Although the volatility is not strong, it will also be partially volatile under certain conditions, such as high temperature and ventilated environment. This characteristic needs to be considered during storage and use to prevent loss due to volatilization or affect the environment.

In summary, the physical properties of 2-% (4-fluorophenyl) thiophene, such as appearance, melting point, solubility, density and volatility, are of important guiding value for its research and application, helping researchers and producers to better control this substance and exert its function.

What are the synthesis methods of 2- (4-fluorophenyl) thiophene?

2-%284-fluorophenyl%29thiophene that is, 2 - (4 - fluorophenyl) thiophene, there are many ways to synthesize this compound, which are described in detail below.

One is a palladium-catalyzed cross-coupling reaction. First, 4 - fluorobromobenzene and thiophene - 2 - boronic acid are taken as raw materials, and in an organic solvent such as dioxane or toluene, a palladium catalyst such as tetra (triphenylphosphine) palladium (0) is added, and an appropriate amount of base is added, such as potassium carbonate or sodium carbonate. Under the condition of heated reflux, the Suzuki cross-coupling reaction occurs between the two. This reaction activates the aryl halogen and the aryl boronic acid through a palladium catalyst to promote the formation of carbon-carbon bonds, and finally obtains 2- (4-fluorophenyl) thiophene. Its advantages are that the reaction conditions are mild, the selectivity is good, and the yield is quite high; however, the palladium catalyst is expensive, and the reaction equipment and operation requirements are also strict.

The second is the Grignard reagent method. First, 4-fluorobromobenzene is reacted with magnesium chips in anhydrous ether or tetrahydrofuran to prepare 4-fluorophenyl magnesium bromide Grignard reagent. Subsequently, the Grignard reagent is slowly dropped into the ether solution of thiophene-2-formaldehyde. After the reaction is completed, the target product can be obtained through post-treatment steps such as hydrolysis and acidification. The raw materials of this method are easy to obtain and the operation is relatively simple. However, the reaction conditions are harsh, and it needs strict anhydrous and anaerobic, and the Grignard reagent has high activity and poor stability.

The third is the Fu-gram reaction. Using 4-fluorobenzene as the aromatic hydrocarbon substrate and thiophene as the reaction raw material, under the action of Lewis acid catalyst such as anhydrous aluminum trichloride, in a suitable organic solvent such as carbon disulfide, the Fu-gram arylation reaction occurs, and then 2 - (4-fluorophenyl) thiophene is generated. The reaction steps of this method are simple; however, the Lewis acid catalyst has a corrosive effect on the equipment, and the reaction selectivity is sometimes poor, and there are many side reactions.

Synthesis of 2- (4-fluorophenyl) thiophene has its own advantages and disadvantages. In practical application, when considering many factors such as raw material availability, cost, reaction conditions and product purity, choose carefully.

What is the market price of 2- (4-fluorophenyl) thiophene?

I don't know what the market price of 2 - (4 - fluorophenyl) thiophene is. The price of this compound may vary widely due to purity, source, supply and demand. To know its exact price, you can consult chemical suppliers, such as Sinopharm Group Chemical Reagent Co., Ltd., search banner reagent network, etc., where the prices of various products are often listed. You can also look at chemical product trading platforms, such as Gade Chemical Network, etc., or you can get market conditions. Or you can ask industry experts and scientific researchers, who may know the approximate price due to practical experience. However, the market situation changes, the price is changeable, and the real-time price must be checked in person.

What is the chemical stability of 2- (4-fluorophenyl) thiophene?

2-%284-fluorophenyl%29thiophene is 2 - (4 - fluorophenyl) thiophene, the chemical stability of this substance, when its structure is carefully examined. It is formed by connecting a thiophene ring with a 4 - fluorophenyl group. The thiophene ring is aromatic, and because it conforms to the Hocker rule, there are 6 π electrons delocalized on the ring, which gives it a certain stability.

From the perspective of bond energy, C-C bond and C-H bond energy are quite high, and a large amount of energy is required to break, which is one of the reasons for its stability. In 4 - fluorophenyl group, the fluorine atom has strong electronegativity. When connected to the benzene ring, the electron cloud density of the benzene ring is reduced by induction effect. However, it can also give electrons through the conjugation effect. The combined effect of the two has an impact on the overall stability.

In case of common reagents, at room temperature and pressure, it has a certain resistance to electrophilic reagents due to its aromatic structure. In case of electrophilic substitution reaction, the activity of thiophene ring and benzene ring is different, depending on the reaction conditions and the selectivity of the reagent. However, under extreme conditions such as high temperature, strong oxidant or strong acid and strong base, its stability gradually loses. For example, strong oxidant can break its aromatic structure and cause it to undergo oxidation reaction; strong acid and strong base or change the substituent on the ring, which affects the overall stability.

In summary, 2 - (4 -fluorophenyl) thiophene has considerable chemical stability under normal temperature and pressure, but under extreme conditions, the structure and stability are volatile.