What is the main use of 2- (4-chlorophenoxy) -5- (trifluoromethyl) aniline?

2-%284-chlorophenoxy%29-5-%28trifluoromethyl%29aniline is 2- (4-chlorophenoxy) -5- (trifluoromethyl) aniline, which has a wide range of uses.

In the field of pharmaceutical synthesis, it can be called an important intermediate. For example, some compounds with specific pharmacological activities are prepared, which are often relied on as the starting material. After a series of delicate chemical reactions, pharmaceutical ingredients with unique curative effects are derived, or they act on specific disease targets, bringing hope for disease treatment.

In the field of pesticide creation, it also occupies a key position. With its special chemical structure, many efficient and low-toxic pesticide products can be synthesized. These pesticides can effectively control various crop diseases and pests, improve crop yield and quality, and escort agricultural harvests.

In the field of materials science, it has also made its mark. It can participate in the synthesis of special polymer materials, endowing materials with unique properties such as excellent chemical stability and thermal stability. It can show its talents in high-end fields such as electronics and aerospace, and meet specific environmental and functional requirements.

Furthermore, in the research of organic synthetic chemistry, as an important organic reagent, it provides rich possibilities for the design and synthesis of new compounds, promotes the continuous development of organic synthetic chemistry, and expands the boundaries of human understanding of the structure and properties of organic compounds.

In summary, 2- (4-chlorophenoxy) -5- (trifluoromethyl) aniline plays an indispensable role in many fields such as medicine, pesticides, materials and organic synthesis, and has made outstanding contributions to technological innovation and development in various fields.

What are the synthesis methods of 2- (4-chlorophenoxy) -5- (trifluoromethyl) aniline

To prepare 2 - (4 - chlorophenoxy) - 5 - (trifluoromethyl) aniline, there are many methods, and the following are selected.

First, the corresponding nitro compound can be obtained by reduction. First, a suitable halogenated aromatic hydrocarbon and a phenolic compound are obtained by nucleophilic substitution reaction in the presence of a base and a catalyst. 2 - (4 - chlorophenoxy) - 5 - (trifluoromethyl) nitrobenzene. The halogenated aromatic hydrocarbon used should contain trifluoromethyl, and the phenol is p-chlorophenol. Potassium carbonate and other catalysts such as copper salts can be selected for the base. After obtaining this nitro group, hydrogen and metal catalysts (such as palladium carbon) are used to catalyze hydrogenation reduction at suitable temperatures and pressures, or chemical reducing agents such as iron powder, zinc powder and hydrochloric acid are used to convert nitro groups into amino groups, so as to obtain the target product 2- (4-chlorophenoxy) -5- (trifluoromethyl) aniline.

Second, halogenated aniline derivatives are used as starting materials. First, halogenated aniline is coupled with 4-chlorophenoxy trifluoromethylphenylboronic acid in a palladium-catalyzed reaction. The halogenated aniline used needs to have a halogen atom in a suitable position, such as bromine or iodine atom. The reaction needs to be carried out in the presence of a base and a palladium catalyst. Caesium carbonate is commonly used in alkalis, and palladium catalysts such as tetra (triphenylphosphine) palladium are used. After this coupling reaction, the skeleton of the target product can be directly constructed to obtain 2- (4-chlorophenoxy) -5- (trifluoromethyl) aniline.
Third, it can be reacted through diazotization and substitution reaction paths. First, aniline containing suitable substituents is prepared into diazo salts. This process requires sodium nitrite to react with hydrochloric acid or sulfuric acid under low temperature and acidic conditions. Then, the diazonium salt is reacted with the metal reagent of 4-chlorophenoxy-trifluoromethylbenzene (such as lithium reagent or magnesium reagent), and the diazonium group is replaced to generate the target 2- (4-chlorophenoxy) -5- (trifluoromethyl) aniline.

All synthesis methods have their own advantages and disadvantages. In practical application, the choice needs to be weighed according to various factors such as the availability of raw materials, cost, and difficulty of reaction conditions.

What are the physicochemical properties of 2- (4-chlorophenoxy) -5- (trifluoromethyl) aniline

2-%284-chlorophenoxy%29-5-%28trifluoromethyl%29aniline, the Chinese name is often 2- (4-chlorophenoxy) -5- (trifluoromethyl) aniline. This material has unique physical and chemical properties, which are detailed as follows:
- ** Properties **: It is mostly white to light yellow crystalline powder at room temperature, and it is fine in appearance. Its powder texture is uniform, and it may have a faint luster under light. Due to differences in preparation process and purity, the color may be slightly different.
- ** Melting point **: The melting point range is about 86-89 ° C. When heated to this point, the molecule is energized, the ordered structure of the lattice is destroyed, and the solid state gradually melts into a liquid state. The precise melting point is affected by purity, and impurities will reduce the melting point and widen the melting range. < Br > - ** Boiling point **: The boiling point value is about 320-325 ° C. At this temperature, the liquid vapor pressure and external atmospheric pressure, etc., a large amount of liquid vaporizes and escapes. Due to the structure containing chlorine, fluorine atoms and benzene rings, the intermolecular forces are complex and cause the boiling point to be higher.
- ** Solubility **: Slightly soluble in water, because the molecule contains hydrophobic benzene ring and lipophilic trifluoromethyl, water molecules have weak interaction with it. However, it has good solubility in common organic solvents such as ethanol, dichloromethane, N, N-dimethylformamide (DMF). In ethanol, it is dissolved by the interaction of intermolecular hydrogen bonds and van der Waals forces with ethanol molecules; in non-polar organic solvents such as dichloromethane, it is soluble due to the principle of similar miscibility.
- ** Stability **: Under conventional storage conditions, it is relatively stable in a dry and cool place. However, in case of strong oxidants, strong acids, and strong bases, the structure may change. In case of strong acids, amino groups or protons; in case of strong bases, phenoxy groups may react. And light and high temperature will accelerate decomposition, causing some chemical bonds in the structure to break.
- ** Toxicity **: Toxicity data is limited, due to halogen atoms, or certain biological toxicity. During operation, protective measures should be taken to avoid inhalation of dust, contact with skin, and accidental ingestion to prevent damage to health.

What is the price range of 2- (4-chlorophenoxy) -5- (trifluoromethyl) aniline in the market?

Today there are 2 - (4 - chlorophenoxy) - 5 - (trifluoromethyl) aniline, the market price range is uncertain. Because the market conditions are changing rapidly, it is subject to many factors. First, the price of raw materials is related to cost. If the supply of chlorobenzene and trifluoromethyl related raw materials is tight, the price will rise, and the price of this aniline will also rise; on the contrary, if the supply is abundant, the price may stabilize and decline. Second, the complexity and sophistication of the production process, whether it is advanced or not, affects the production capacity and quality. The exquisite and advanced process may reduce costs and increase output, making the price competitive; the complicated and backward method is the opposite. Third, market demand is essential. If the demand for this aniline in the pharmaceutical, pesticide and other industries is strong, the supply is in short supply, and the price must be high; if the demand is weak and the supply is oversupplied, the price will fall.

Looking at the market in the past, the prices of similar chemicals fluctuated frequently. There was a new type of aniline derivative that was initially listed due to technical monopoly and urgent demand, and the price was high. Later, with the popularization of technology and the increase in production capacity, the price gradually declined. From this, the price of 2- (4-chlorophenoxy) -5- (trifluoromethyl) aniline may fluctuate between tens of yuan and hundreds of yuan per kilogram. However, if you want to know the exact price, you must check the chemical raw material trading platform in real time and consult the industry's Jia expert to get an accurate number.

2- (4-chlorophenoxy) -5- (trifluoromethyl) aniline

Today there is a question, what is the manufacturer of 2- (4-chlorophenoxy) -5- (trifluoromethyl) aniline? This compound is a key intermediate in the field of organic synthesis, and is widely used in many industries such as medicine and pesticides.

As far as its manufacturers are concerned, there are many companies in China involved in this field. For example, a chemical enterprise in Jiangsu, with its profound accumulation of chemical technology, is well-versed in the synthesis process of fine chemicals. The production of 2- (4-chlorophenoxy) -5- (trifluoromethyl) aniline, from the control of raw materials to the precise regulation of reaction conditions, is unique, with high product quality and a good reputation in the industry.

There is also an enterprise in Shandong, focusing on the research and development and production of fluorine-containing compounds. Supported by advanced fluorination technology, he optimizes the reaction path, improves the output efficiency, and pays attention to environmental protection measures in the preparation process of 2- (4-chlorophenoxy) -5- (trifluoromethyl) aniline, making the production process more green and sustainable.

Overseas, there are also many such manufacturers in Europe, America. A well-known chemical company in the United States, with its strong scientific research strength and complete production system, has a large production scale for this compound, and can keep up with market demand, continuously improve the production process, and meet the diverse needs of different customers around the world. Some European fine chemical companies also specialize in the production of such specialty chemicals. Their fine craftsmanship and attention to quality details make 2- (4-chlorophenoxy) -5- (trifluoromethyl) aniline highly competitive in the high-end market.

If you want to know all the manufacturers, you need to search for chemical information, industry reports, or field research on the location of the chemical industry cluster to learn more.