What is the chemical structure of (1S) -2-chloro-1- [ (2S) -6-fluorochroman-2-yl] ethanol?

This is a problem related to the chemical structure of (1S) -2 -chloro-1- [ (2S) -6 -fluorochrome-2-yl] ethanol. To clarify its chemical structure, we should start with the nomenclature.

" (1S) -2 -chloro-1- [ (2S) -6 -fluorochrome-2-yl] ethanol", this nomenclature follows the nomenclature of organic chemistry. "Ethanol" is the parent structure, and its two carbon chains containing hydroxyl groups (-OH). "2-chlorine" is shown to have a chlorine atom substituted at position 2 of the parent ethanol. And "1- [ (2S) -6-fluoro chroman-2-group]" indicates that a specific substituent is connected at the ethanol 1 position.

Where "chroman" is a structure containing a six-membered benzene ring and a five-membered oxygen-containing heterocycle. " (2S) -6-fluoro chroman-2-group", " (2S) " The configuration of the epigenetic full ring at position 2 is S-type, "6-fluoro" refers to the fluorine atom substitution at position 6 of the chroman ring, and "2-group" indicates that the chroman structure is connected to the ethanol position 1 through position 2.

From a comprehensive perspective, the chemical structure of (1S) -2-chloro-1- [ (2S) -6-fluorochrome-2-group] ethanol is an organic compound with ethanol as the parent, chlorine atoms at position 2, and (2S) -6-fluorochrome-2-group at position 1. Its structure contains not only benzene rings, heterocycles, but also halogen atoms and hydroxyl groups. Each atom and group are arranged and combined according to specific rules, so this unique chemical structure is formed.

What are the physical properties of (1S) -2-chloro-1- [ (2S) -6-fluorochroman-2-yl] ethanol?

(1S) -2 -chloro-1- [ (2S) -6 -fluorochroman-2-based] ethanol, this is an organic compound. Its physical properties are quite critical and related to many fields of application.

Looking at its appearance, it often takes the form of a colorless to light yellow liquid, and shines with a unique luster in the sun, as if it contains natural mysteries. This compound has a certain density and is slightly heavier than water, so it sinks to the bottom in water, like a treasure hidden in the bottom of the water.

When it comes to melting point, due to the characteristics of molecular structure, its melting point is in a relatively low range, about -20 ° C, just like the potential to flow at low temperatures in winter. The boiling point is higher, about 250 ° C, and a higher temperature is required to make it boil into a gaseous state, just like a substance that can be sublimated after much hardship.

In terms of solubility, the compound has good solubility in organic solvents, such as ethanol, ether, etc., which can be fused with it, just like like like-minded friends, but it has poor solubility in water, just like water and oil.

In addition, its refractive index is also one of the important physical properties. The specific refractive index reflects the characteristics of molecular arrangement and light interaction, which is like a unique optical fingerprint, providing an important basis for the identification and study of this compound. In short, the physical properties of this compound are of great significance in the fields of organic synthesis and drug development, and are like the key to opening the door to scientific exploration.

What are the main uses of (1S) -2-chloro-1- [ (2S) -6-fluorochroman-2-yl] ethanol?

(1S) -2-chloro-1- [ (2S) -6-fluorochroman-2-yl] ethanol, this compound is widely used in the field of medicinal chemistry and organic synthesis.

In medicinal chemistry, it can be used as a key intermediate to prepare many bioactive compounds. For the creation of antibacterial, antiviral and anti-tumor drugs, it is often used as a starting material. Due to its specific stereochemical structure, the resulting drugs have unique pharmacological activity and selectivity. Taking the development of anti-tumor drugs as an example, compounds derived from (1S) -2 -chloro-1- [ (2S) -6 -fluorochrome-2-yl] ethanol can precisely act on specific targets of tumor cells, inhibit the proliferation and metastasis of tumor cells, and cause little damage to normal cells, improving the efficacy and safety of drugs.

In the field of organic synthesis, this compound is also an important synthetic building block. The chlorine atom and alcohol hydroxyl group contained in its structure, as well as the unique structure of the chrome ring, provide various possibilities for organic reactions. Through nucleophilic substitution, esterification, oxidation and other reactions, it can be structurally modified and derivatized to build more complex organic molecular structures. For example, through nucleophilic substitution reactions, chlorine atoms can be replaced with other functional groups, expanding the structural diversity of compounds and laying the foundation for the study of new materials and total synthesis of natural products.

In summary, (1S) -2 -chloro-1- [ (2S) -6 -fluorochroman-2-yl] ethanol is as important as a cornerstone in the field of medicine and organic synthesis, and plays an indispensable role in promoting the development of related fields.

What are the synthesis methods of (1S) -2-chloro-1- [ (2S) -6-fluorochroman-2-yl] ethanol?

The synthesis of (1S) -2-chloro-1- [ (2S) -6-fluoro-chroman-2-yl] ethanol is an important topic in organic synthetic chemistry. The synthesis of this compound often requires delicate strategies and skills.

In the past, organic synthesis began, and chemists relied heavily on the transformation of natural products to obtain target molecules. However, for (1S) -2-chloro-1- [ (2S) -6-fluoro-chroman-2-yl] ethanol, natural resources are directly supplied, so artificial creation is required. < Br >
One method is to prepare the chromatic ring structure first, and use the appropriate phenolic compound as the starting material to construct the chromatic framework through cyclization reaction. For example, 2-hydroxyacetophenone derivatives, under acidic or basic catalysis, undergo nucleophilic substitution with appropriate halogenated hydrocarbons, and then cyclize to form the chromatic structure. When constructing the chromatic ring, attention should be paid to the control of stereochemistry. The reaction can be guided by chiral catalysts or chiral additives to obtain the (2S) -6-fluorine chromatic-2-based configuration. < Br >
When the chromatic ring is obtained, an ethanol fragment is introduced at its 2-position, and a chlorine atom is introduced at the 2-position of ethanol. In this step, a nucleophilic substitution reaction may be used to react with an appropriate derivative of the chromatic ring with a nucleophilic reagent containing an ethanol fragment. For example, (2S) -6-fluorochromatic-2-formaldehyde is used as a substrate to reduce the corresponding alcohol, and then a chlorination reagent, such as sulfoxide chloride, is used to convert the alcohol hydroxyl group into a chlorine atom. In this process, the reaction conditions need to be carefully controlled so as not to affect the three-dimensional configuration.

Another method, or a convergence synthesis strategy can be used. The chroman ring fragment and the chlorine-containing ethanol fragment were constructed respectively, and then the two were connected by a suitable coupling reaction. If the coupling reaction is catalyzed by metal, such as Suzuki coupling, Negishi coupling, etc., if the fragment is suitable, the target product may be obtained efficiently, and the stereochemistry can be well controlled. In short, the synthesis of (1S) -2 -chloro-1 - [ (2S) -6 -fluorochroman-2-yl] ethanol requires chemists to think about the reaction path carefully, precisely control the reaction conditions and stereochemistry, and then successfully obtain this compound.

What is the market outlook for (1S) -2-chloro-1- [ (2S) -6-fluorochroman-2-yl] ethanol?

(1S) -2-chloro-1- [ (2S) -6-fluorochrome-2-yl] ethanol, an organic compound. Looking at its market prospects, there are multiple considerations.

In the field of pharmaceutical research and development, it may have significant potential. Because organic compounds are often key intermediates in drug synthesis. The unique structure of (1S) -2-chloro-1- [ (2S) -6-fluorochrome-2-yl] ethanol may provide an opportunity for the creation of new drugs. Many drug research and development institutions often seek such compounds with special structures in order to develop highly effective drugs for specific diseases. If they can participate in the drug synthesis path and the synthesized drugs are favored in the market, such as anti-cancer and antiviral drugs, the market demand will be considerable and the prospects will be bright.

However, there are also challenges and opportunities in the chemical production level. Synthesis of this compound requires precise processes and conditions, and there are high requirements for reaction equipment and technicians. If technical problems can be overcome, large-scale production can be achieved, and costs can be controlled, it may have a place in the chemical raw material market. However, if there are technical bottlenecks in the production process and the cost remains high, it will be difficult to compete with congeneric products, and market expansion will also be hindered.

Furthermore, with the increase of environmental awareness, the environmental friendliness of the production process is also an important factor. If the production process complies with environmental regulations, the waste discharge is low, and the treatment is easy, it can adapt to the market trend and gain more market share; on the contrary, if it is limited due to environmental protection issues, its market prospect may be clouded.

In summary, the market prospect of (1S) -2 -chloro-1- [ (2S) -6 -fluorochrome-2-based] ethanol depends on many aspects such as pharmaceutical research and development achievements, chemical production technology and environmental compliance. Only by properly addressing the challenges of all parties can it emerge in the market and seek broad development space.