What is the chemical structure of (1R, 3S) -3- ((1Z) -2-chloro-3,3, 3-trifluoroprop-1-en-1-yl) -2, 2-dimethylcyclopropanecarbonyl chloride?

The Chinese name of this compound is (1R, 3S) -3- ((1Z) -2-chloro-3,3,3-trifluoropropane-1-ene-1-yl) -2,2-dimethylcyclopropane formyl chloride.

To know its chemical structure, it is necessary to analyze the name step by step. " (1R, 3S) " indicates the chiral configuration of carbons 1 and 3 on cyclopropane. "Cyclopropane formyl chloride" indicates that the main structure is cyclopropane and there are formyl chloride groups attached to cyclopropane. "2,2-dimethyl" means that there are two methyl groups attached to the cyclopropane 2 carbon. " 3- ((1Z) -2 -chloro-3,3,3-trifluoropropane-1-ene-1-yl) "means that there is a substituent attached to the cyclopropane-3 carbon, which is a propylene group containing double bonds. The double bond configuration is Z-type, the No. 2 carbon has chlorine atoms, and the No. 3 carbon has three fluorine atoms.

Its chemical structure is depicted as follows: first draw a cyclopropane, and determine the spatial orientation of atoms or groups in the cyclopropane No. 1 carbon and No. 3 carbon according to the R and S configuration rules; connect two methyl groups on the No. 2 carbon; connect a (1Z) -2-chloro-3,3,3-trifluoropropane-1-ene-1-group substituent on the No. 3 carbon, that is, a propylene group, wherein each of the double-bonded carbons is connected to a specific atom or group to conform to the Z-type configuration, and the No. 2 carbon is connected to chlorine, and the No. 3 carbon is connected to three fluorine groups; at the same time, the cyclopropane is connected to formyl chloride groups. In this way, the chemical structure of (1R, 3S) -3- ((1Z) -2-chloro-3,3,3-trifluoropropyl-1-ene-1-yl) -2,2-dimethylcyclopropanoyl chloride is outlined.

What are the main uses of (1R, 3S) -3- ((1Z) -2-chloro-3,3,3-trifluoroprop-1-en-1-yl) -2, 2-dimethylcyclopropanecarbonyl chloride?

(1R, 3S) -3- ((1Z) -2-chloro-3,3,3-trifluoropropane-1-ene-1-yl) -2,2-dimethylcyclopropanoyl chloride, which is widely used. In the field of organic synthesis, it is often used as a key intermediate, just like the cornerstone of building a delicate castle. It can be combined with various reactions and various reagents to build complex organic compounds, just like skilled craftsmen carve unique things with exquisite skills.

It is also of great value in the research and development of medicine. Or it can participate in the preparation of drug molecules with specific biological activities, contributing to the conquest of diseases and the protection of health, just like a good medicine in the hands of a doctor, which can cure diseases. And in the field of material science, with rational application, it may lay the foundation for the creation of new materials with special properties, such as adding bricks to the world of materials, making it glow with new brilliance. In short, this compound has room for use in many fields, and its uses are rich and critical.

What is the preparation method of (1R, 3S) -3- ((1Z) -2-chloro-3,3, 3-trifluoroprop-1-en-1-yl) -2, 2-dimethylcyclopropanecarbonyl chloride?

To prepare (1R, 3S) -3- ((1Z) -2-chloro-3,3,3-trifluoropropylene-1-ene-1-yl) -2,2-dimethylcyclopropanoyl chloride, the method is as follows:

Take the appropriate starting material first, usually based on a cyclopropane derivative with a specific configuration. A dimethylcyclopropane-containing structure can be found, and a reactive functional group can be reserved at a suitable position for subsequent introduction of (1Z) -2-chloro-3,3,3-trifluoropropane-1-ene-1-based moiety.

For the introduction of (1Z) -2-chloro-3,3,3-trifluoropropane-1-ene-1-based fragments, a suitable nucleophilic substitution or addition reaction can be selected. If a halogenated hydrocarbon or alkenyl halide is reacted with the activity check point of cyclopropane derivatives, the reaction will proceed in the direction of the target product with a suitable base or catalyst. During the reaction, attention should be paid to the control of the reaction conditions, such as temperature, solvent and reactant ratio. Too high or too low temperature may affect the reaction rate and product configuration. Suitable solvents can improve the solubility and reactivity of the reactants.

After the successful introduction of (1Z) -2-chloro-3,3,3-trifluoropropane-1-ene-1-group, it can be converted to formyl chloride. Chlorination reagents, such as dichlorothionyl, can be used to react with the obtained product to convert the corresponding carbonyl compound into formyl chloride. This step also needs to pay attention to the reaction conditions to avoid excessive chlorination or other side reactions. After separation and purification, such as column chromatography, recrystallization, etc., to obtain high-purity (1R, 3S) -3- ((1Z) -2-chloro-3,3,3-trifluoropropane-1-ene-1-yl) -2,2-dimethylcyclopropane formyl chloride.

What are the physical properties of (1R, 3S) -3- ((1Z) -2-chloro-3,3, 3-trifluoroprop-1-en-1-yl) -2, 2-dimethylcyclopropanecarbonyl chloride?

(1R, 3S) -3- ((1Z) -2-chloro-3,3,3-trifluoropropene-1-yl) -2,2-dimethylcyclopropanoformyl chloride, an organic compound with unique physical properties.

It is a volatile liquid with a certain degree of volatility. At room temperature and pressure, the boiling point is about a specific range, depending on the precise measurement conditions, or between [X] ℃ and [X] ℃. This boiling point characteristic makes it easier to change from liquid state to gaseous state under heating or certain environments.

The density of this compound is also an important physical property, with a density of about [X] g/cm ³. This value determines its sinking and floating in different media. If mixed with water, its position above and below the water layer can be judged according to the comparison of its density and water density.

In terms of solubility, due to the hydrophobic groups contained in the molecular structure, the solubility in water is very low and nearly insoluble. However, it exhibits good solubility in common organic solvents, such as dichloromethane, chloroform, ether, etc. This solubility characteristic makes these organic solvents often used as the reaction medium in organic synthesis reactions.

In appearance, the compound usually presents a colorless to light yellow transparent liquid state, which is visually clear and transparent. This appearance feature helps to preliminarily judge its purity and state in experimental observation or industrial production.

In addition, (1R, 3S) -3- ((1Z) -2-chloro-3,3,3-trifluoropropene-1-yl) -2,2-dimethylcyclopropanoformyl chloride has a certain chemical activity. The chlorine atom and carbonyl group in the molecule make it easy to participate in a variety of chemical reactions, such as nucleophilic substitution reactions, and has important uses in the field of organic synthesis.

What are the chemical properties of (1R, 3S) -3- ((1Z) -2-chloro-3,3, 3-trifluoroprop-1-en-1-yl) -2, 2-dimethylcyclopropanecarbonyl chloride?

(1R, 3S) -3- ((1Z) -2-chloro-3,3,3-trifluoropropane-1-ene-1-yl) -2,2-dimethylcyclopropane formyl chloride, this is an organic compound with specific chemical properties.

It contains chlorine atoms and trifluoromethyl groups. Due to the high electronegativity of halogen atoms, the molecules are polar, which affects the physical and chemical properties. Containing acyl chloride functional group (-COCl), the chemical properties are active. Acyl chloride is easy to hydrolyze and reacts in contact with water to form corresponding carboxylic acids and hydrogen chloride, and the reaction is violent. Example: (1R, 3S) -3- ((1Z) -2-chloro-3,3,3-trifluoropropyl-1-ene-1-yl) -2,2-dimethylcyclopropanoyl chloride is rapidly hydrolyzed into (1R, 3S) -3- ((1Z) -2-chloro-3,3,3-trifluoropropyl-1-ene-1-yl) -2,2-dimethylcyclopropanecarboxylic acid and hydrogen chloride.

can also undergo alcoholysis with alcohol to form ester compounds. If reacted with ethanol, (1R, 3S) -3- ((1Z) -2-chloro-3,3,3-trifluoropropyl-1-ene-1-yl) -2,2-dimethylcyclopropanecarboxylic acid ethyl ester and hydrogen chloride are formed. When reacted with ammonia or amine, ammonolysis occurs to form an amide. If reacted with ammonia, (1R, 3S) -3- ((1Z) -2-chloro-3,3,3-trifluoropropane-1-ene-1-yl) -2,2-dimethylcyclopropane formamide and ammonium chloride can be obtained.

The cyclopropane structure in this compound makes the molecule have unique reactivity due to ring tension, making it more prone to ring-opening reactions and participating in various organic synthesis reactions to prepare complex organic compounds.