What is the main use of 1- [3-chloro-5- (trifluoromethyl) phenyl] -2,2,2-trifluoroethanone

1-% 5B3 -chloro-5- (trifluoromethyl) phenyl% 5D-2,2,2 -trifluoroethyl ketone is a kind of organic compound. Its main use is quite important in the field of organic synthesis.

This compound is often used as an intermediate. To cover the process of organic synthesis, various intermediates are needed to form a complex molecular structure. 1-% 5B3 -chloro-5- (trifluoromethyl) phenyl% 5D-2,2,2 -trifluoroethyl ketone can participate in various chemical reactions due to its unique chemical structure. < Br >
First, in the aromatization reaction, it can interact with many reagents containing aryl groups. This reaction or through the mechanism of nucleophilic substitution, makes the chlorine atom or trifluoromethyl in the molecule combine with foreign aryl groups, thereby expanding the conjugate system of the molecule, or introducing specific functional groups, laying the foundation for the generation of organic materials with special properties.

Second, it is also a key raw material when constructing fluorine-containing heterocyclic compounds. Fluorine-containing heterocyclic compounds are widely used in the fields of medicine, pesticides, etc. The fluorine atom of 1-% 5B3 -chloro-5- (trifluoromethyl) phenyl% 5D-2,2,2 -trifluoroethyl ketone can enhance the lipophilicity of compounds, change their electron cloud distribution, and enhance biological activity. By reacting with suitable heteroatom reagents such as nitrogen and oxygen, the heterocyclic structure can be cleverly constructed to create new drug lead compounds or high-efficiency pesticide ingredients.

Furthermore, in the field of materials science, materials with special optical and electrical properties can be prepared by using this compound as a starting material through specific reactions. If it participates in the polymerization reaction to form a fluoropolymer, it imparts excellent weather resistance and chemical stability to the material, and has potential applications in high-end coatings, electronic device packaging materials, etc.

What are the synthesis methods of 1- [3-chloro-5- (trifluoromethyl) phenyl] -2,2,2-trifluoroethanone

To prepare 1 - [3-chloro-5 - (trifluoromethyl) phenyl] -2, 2, 2 -trifluoroethyl ketone is often obtained by the ancient method of organic synthesis. There are many methods, and several common methods are described in detail below.

First, it can be obtained by the reaction of fluorohalogenated hydrocarbons and acyl halides by Fu-gram acylation. First, 3-chloro-5 - (trifluoromethyl) chlorobenzene is taken as the starting material, and this halogenated aromatic hydrocarbon is active. Lewis acid such as anhydrous aluminum trichloride is used as a catalyst, in a suitable solvent, such as dichloroethane, etc., to make it react with 2,2,2-trifluoroacetyl chloride. When reacting, it is necessary to pay attention to the control of reaction temperature and time. If the temperature is too high, it is easy to produce side reactions, resulting in impure products; if the temperature is too low, the reaction rate is slow. Generally speaking, the temperature is controlled between 0 ° C and room temperature. When the reaction number is reached, the target product can be obtained by separation and purification techniques, such as column chromatography.

Second, it can also be prepared by halogenation and arylation of fluorine-containing ketones. First, a suitable 2,2,2-trifluoroacetone derivative is used as a base, and a suitable halogenating agent, such as N-chlorosuccinimide, is halogenated under suitable conditions to introduce a halogen atom. Then, the aromatization reaction catalyzed by palladium is interacted with 3-chloro-5- (trifluoromethyl) phenylboronic acid and other arylating reagents. In this process, the choice of palladium catalyst, the choice of ligand, and the type and dosage of base all have a great influence on the reaction. It is necessary to fine-tune the reaction parameters to make the reaction smooth and the product yield is considerable. After subsequent separation and purification, impurities are removed to obtain pure 1- [3-chloro-5- (trifluoromethyl) phenyl] -2,2,2-trifluoroethyl ketone.

Third, it can be obtained by multi-step conversion of carboxylic acids and their derivatives with halogenated aromatic hydrocarbons. First, 2,2,2-trifluoroacetic acid is converted into the corresponding acid chloride or anhydride, and then reacted with 3-chloro-5- (trifluoromethyl) phenyl Grignard reagent or lithium reagent to form a carbon-carbon bond. This reaction requires strict reaction conditions, and the reagent needs to be anhydrous and oxygen-free. Subsequent hydrolysis, oxidation and other steps, the intermediate product is gradually converted into the target 1 - [3 - chloro - 5 - (trifluoromethyl) phenyl] -2, 2, 2 - trifluoroethyl ketone. Complex separation and purification operations are also required to achieve the purity requirements of the product.

What are the physical properties of 1- [3-chloro-5- (trifluoromethyl) phenyl] -2,2,2-trifluoroethanone

1-% 5B3 -chloro-5- (trifluoromethyl) phenyl% 5D-2,2,2 -trifluoroethyl ketone, this is an organic compound. To know its physical properties, let me tell you in detail.

Looking at its shape, it is usually liquid at room temperature and pressure. Due to the moderate intermolecular force, it is not enough to solidify it into a solid state, and it is difficult to make it volatile into a gaseous state. Its appearance is either colorless and transparent, or slightly colored. Due to the characteristics of the atoms and structures contained, it absorbs and reflects light differently.

When it comes to smell, it often has a special organic smell. However, this smell is neither pungent nor pleasant, but belongs to the smell of a specific organic compound, which is related to the structure of chlorine atoms, fluorine atoms and carbonyl groups in the molecule.

In terms of solubility, because the compound has a certain polarity, it should have good solubility in organic solvents such as ethanol, ether, and dichloromethane. Due to the principle of "similar miscibility", the polarity of the organic solvent is similar to that of the compound, and the intermolecular forces can interact to promote dissolution. However, in water, its solubility may not be good. Although the polarity of the edge water is strong, it is difficult to form an effective interaction with the compound due to its large structural difference.

Boiling point and melting point are also important physical properties. Its boiling point is affected by van der Waals force, halogen atom and carbonyl group between molecules, or is in a specific temperature range. The increase of halogen atoms in the molecule enhances the intermolecular force and increases the boiling point. The melting point is related to the regularity of molecular arrangement. The structure or melting point of this compound also have corresponding values, which need to be accurately determined by experiments.

The density may be different from that of water. Due to the different types and quantities of atoms in the molecule, the ratio of mass to volume is different, either greater than or less than water, which is closely related to the molecular structure.

In summary, the physical properties of 1-% 5B3 -chloro-5- (trifluoromethyl) phenyl% 5D-2,2,2 -trifluoroethyl ketone are affected by molecular structure, and have unique manifestations in morphology, odor, solubility, melting point, density, etc.

What are the chemical properties of 1- [3-chloro-5- (trifluoromethyl) phenyl] -2,2,2-trifluoroethanone

1-% 5B3 -chloro-5- (trifluoromethyl) phenyl% 5D-2,2,2 -trifluoroethyl ketone, this compound has unique chemical properties. In terms of physical properties, it is mostly liquid under normal conditions. Due to the presence of many fluorine atoms, the intermolecular force changes, the boiling point is relatively low, and the volatility is strong. Pay attention to its volatile characteristics during organic synthesis operations.

Chemical properties, carbonyl is the key activity check point. Affected by ortho-chlorine atoms and trifluoromethyl groups, carbonyl carbons have enhanced positive electrical properties, high nucleophilic reactivity, and are prone to addition reactions with alcohols and amines. For example, ketals can be formed when reacting with alcohols, which is often used as a carbonyl protection strategy in organic synthesis; when reacting with amines, imines are formed, which is an important step in the construction of complex structures such as nitrogen-containing heterocycles.

In addition, chlorine atoms on the benzene ring can participate in nucleophilic substitution reactions. Although the benzene ring is stable, under appropriate conditions and the action of strong nucleophilic reagents, chlorine atoms can be replaced, providing a way for the introduction of new functional groups. However, trifluoromethyl has strong electron absorption, which not only affects the electron cloud density of the benzene ring, changes the selectivity of the substitution reaction region on the benzene ring, but also enhances the fat solubility of the compound, which affects its pharmacokinetic properties such as absorption, distribution and metabolism in vivo. It is widely used in the field of medicinal chemistry and can improve drug activity and stability.

What is the price range of 1- [3-chloro-5- (trifluoromethyl) phenyl] -2,2,2-trifluoroethanone in the market?

I don't know the price range of 1- [3-chloro-5- (trifluoromethyl) phenyl] -2,2,2-trifluoroethyl ketone in the market. This compound is very familiar, and its price is affected by many factors.

First, the difficulty of preparation has a great impact. If the preparation requires cumbersome steps, rare raw materials or harsh reaction conditions, the cost will be high, and the price will also rise. Second, the amount of market demand is also the key. If an industry has strong demand for this product, the supply is in short supply, and the price may increase; conversely, the demand is very low, and the price may decrease. Third, different suppliers have different prices. Each supplier has different pricing due to their own cost control and business strategies.

After searching the price lists of common chemical products and chemical trading platforms, it is difficult to find the exact price range of this product. Or because it is not a commonly used product in wide circulation, it is only occasionally needed in specific fields, specific research or production. If you want to know its price, you can consult professional chemical raw material suppliers, chemical trading institutions, or ask industry insiders in relevant professional forums to get a more accurate price range.