What is the chemical structure of 1- (3- (4-fluorophenoxy) propyl) -3-methoxy-4-piperidinone?

This is the naming of an organic compound. To clarify its chemical structure, it is necessary to follow the naming rules of organic chemistry. "1- (3- (4-fluorophenoxy) propyl) -3-methoxy-4-piperidone", from which it can be seen that its core structure is piperidone. The No. 1 position of the piperidone ring is connected with a substituent. This substituent is composed of 3- (4-fluorophenoxy) propyl, which means that one end of the propyl group is connected to the No. 1 position of piperidone, the other end of the propyl group is connected with a phenoxy group, and the No. 4 position of the benzene ring is substituted with a fluorine atom. The third position of the piperidone ring is connected with a methoxy group.

In this way, the chemical structure of this compound can be roughly outlined. It is based on piperidone and is connected with fluorophenoxy propyl and methoxy groups at specific positions. With the information given by the nomenclature of organic chemistry, its structural model can be constructed to help in-depth understanding of the chemical properties and reactivity of this compound.

What are the main uses of 1- (3- (4-fluorophenoxy) propyl) -3-methoxy-4-piperidinone?

1 - (3 - (4 - fluorophenoxy) propyl) - 3 - methoxy - 4 - piperidone has a wide range of uses. In the field of medicinal chemistry, such compounds are often key intermediates for the creation of new drugs. Due to their unique chemical structure, they can interact with specific targets in organisms or exhibit diverse biological activities.

For example, in the development of drugs for neurological diseases, their structural properties may be used to design and synthesize drugs with specific effects on neurotransmitter regulation, which is expected to provide new approaches and strategies for the treatment of difficult neurological diseases such as Parkinson's disease and Alzheimer's disease.

In the field of organic synthetic chemistry, 1 - (3 - (4 - fluorophenoxy) propyl) - 3 - methoxy - 4 - piperidone is also an important synthetic building block. With its active functional groups, more complex and diverse organic molecular structures can be constructed through many organic reactions, such as nucleophilic substitution and addition reactions, laying the foundation for the creation of new materials and fine chemicals.

Furthermore, in the field of pesticide chemistry, this compound or its impact on certain biological activities, after reasonable modification and modification, may be able to develop new pesticides with high efficiency, low toxicity and environmental friendliness to meet the higher needs of modern agriculture for pest control.

In short, 1- (3- (4-fluorophenoxy) propyl) -3-methoxy-4-piperidone has significant potential value and application prospects in many chemical related fields, and is an important compound that cannot be ignored in chemical research and industrial production.

What is the synthesis method of 1- (3- (4-fluorophenoxy) propyl) -3-methoxy-4-piperidinone?

To prepare 1 - (3 - (4 - fluorophenoxy) propyl) - 3 - methoxy - 4 - piperidone, the method is as follows:
First take 4 - fluorophenol, place it in the reaction kettle, add an appropriate amount of alkali, such as sodium hydroxide, to help its phenolic hydroxyl group to form phenoxy anion, enhance nucleophilicity. Then add 1,3 - dibromopropane, and control the temperature to make the two nucleophilic substitution reaction. In this step, the phenoxy anion nucleophilic attacks the carbon-bromine bond of 1,3 - dibromopropane, and the bromine ion leaves to obtain 3- (4 - fluorophenoxy) propane. After the reaction is completed, it is separated and purified by methods such as extraction and distillation to obtain a pure product.
Another 3-methoxy-4-piperidone is prepared, and suitable raw materials, such as ethyl methoxy acetoacetate, are reacted with ammonia or amino-containing compounds under specific conditions according to the mechanism of condensation and cyclization to form 3-methoxy-4-piperidone. Similarly, after separation and purification, pure 3-methoxy-4-piperidone is obtained. At the end of
, place 3- (4-fluorophenoxy) propane with 3-methoxy-4-piperidone in a suitable solvent, such as ethanol, add a catalyst, such as potassium carbonate, and heat to reflux. The terminal carbon of 3- (4-fluorophenoxy) propane is attacked by the active site in 3-methoxy-4-piperidone. After nucleophilic substitution, 1- (3- (4-fluorophenoxy) propyl) -3-methoxy-4-piperidone is obtained. At the end of the reaction, the pure target product can be obtained by means of recrystallization and column chromatography. Therefore, following this step, the compound can be formed.

What are the physical properties of 1- (3- (4-fluorophenoxy) propyl) -3-methoxy-4-piperidinone?

1- (3- (4-fluorophenoxy) propyl) -3-methoxy-4-piperidone, this is an organic compound. Its physical properties are quite important, related to its performance in various chemical processes and practical applications.

First, the appearance. Under normal temperature and pressure, it may be solid, and the specific color may be white to white-like crystalline powder, which is as pure as snow. This appearance feature makes it visually easy to identify and distinguish.

Melting point is of great significance to this compound. After experimental determination, its melting point range roughly falls within a specific range, and this value can provide a key basis for identifying the substance. And the melting point is greatly affected by impurities. The melting point of pure things is relatively fixed. If impurities are contained, the melting point may decrease and the melting range becomes wider.

In terms of boiling point, when the external pressure reaches a certain standard, the compound will boil and transform into a gaseous state. The level of boiling point is closely related to the intermolecular forces. Various atoms in its molecular structure interact with functional groups, resulting in a specific strength of the intermolecular forces, which in turn determines the boiling point value. This value is crucial for purifying the compound by means of distillation.

Solubility is also an important property. In organic solvents, such as ethanol, dichloromethane, etc., the compound may exhibit good solubility and can be uniformly dispersed, as if it were integrated into the vast ocean. This is due to the existence of suitable interactions between its molecular structure and organic solvent molecules, such as van der Waals forces, hydrogen bonds, etc. In water, its solubility may be poor. Due to the weak interaction between water molecules and the compound molecule, it is difficult to break the original force between the compound molecules and make it disperse in water.

In terms of density, it has a specific value under certain temperature and pressure conditions. The density is related to the molecular mass and the degree of intermolecular accumulation. The molecular mass and the spatial structure of the compound work together to determine its density. This value is of great significance in some application scenarios where accurate measurement of volume and mass is required. The physical properties of 1- (3- (4-fluorophenoxy) propyl) -3-methoxy-4-piperidone are the cornerstone of understanding its chemical behavior and practical uses, and are indispensable in many fields such as organic synthesis and drug discovery.

What are the chemical properties of 1- (3- (4-fluorophenoxy) propyl) -3-methoxy-4-piperidinone?

1 - (3 - (4 - fluorophenoxy) propyl) - 3 - methoxy - 4 - piperidone is an organic compound. It has the following chemical properties:
- ** Physical properties **: At room temperature, it is mostly white to light yellow crystalline powder, which is relatively stable due to the arrangement and interaction of atoms in the molecule. In terms of melting boiling point, the melting point is about [X] ° C, and the boiling point is about [X] ° C. This is determined by the intermolecular force and structural characteristics. The size of the intermolecular force and molecular rigidity affect the melting boiling point.
- ** Chemical Properties **:
- ** Nucleophilic Substitution Reaction **: The carbonyl group on the piperidone ring in this compound is electrophilic and susceptible to nucleophilic attack. In the case of nucleophilic reagents containing active hydrogen, such as alcohols, amines, etc., carbonyl oxygen will attract the negatively charged or electron-rich part of the nucleophilic reagent, and a nucleophilic addition reaction will occur, followed by dehydration to form new compounds. Taking the reaction with ethanol as an example, under acidic or basic catalysis, the oxygen atom in ethanol nucleophilically attacks carbonyl carbons to form intermediates, and then dehydrates to obtain corresponding acetal products. < Br > - ** Aromatic ring-related reactions **: The benzene ring of the 4-fluorophenoxy moiety has aromatic characteristics and can undergo electrophilic substitution reaction. Because fluorine atoms have electron-sucking induction effect and electron-donating conjugation effect, the electron cloud density distribution of the benzene ring changes, and the electrophilic substitution reaction activity and check point are affected. Usually, electrophilic reagents are more likely to attack the adjacent and para-sites with relatively high electron cloud density on the benzene ring, such as halogenation, nitrification, sulfonation and other reactions.
- ** Reaction of methoxy group **: The methoxy group in the molecule is the power supply radical, which can affect the electron cloud density of the carbon atoms connected to it, and have an effect on the activity of the nearby reaction At the same time, under certain conditions, the methoxy group can also participate in the reaction as a leaving group, such as a substitution reaction under the action of strong acidity or some nucleophiles, which is replaced by other groups.