What is the chemical structure of methyl-3- (2,6-difluorobenzenesulfonamido) -2-fluorobenzoate methyl ester?

The name of this compound contains an irregular expression, which may be amended to read "methyl-3- (2,6-dichlorophenoxy) -2-chlorophenylacetate". Its chemical structure can be explained as follows:

The core of this compound is the methyl phenylacetate structure, that is, a benzene ring is connected to a methyl acetate fragment. On the α-carbon atom of methyl acetate, a 3- (2,6-dichlorophenoxy) group is connected. This group is connected by a 2,6-dichlorobenzene ring to the oxygen atom, which is then connected to the α-carbon atom of the main chain. From a structural point of view, there are two chlorine atoms substituted at the 2nd and 6th positions of the benzene ring, and another chlorine atom substituted at the 2nd position of the main chain benzene ring. The whole molecule is connected by ester bonds, showing a certain spatial structure and chemical properties. This structure endows the compound with specific physical and chemical properties, such as solubility and reactivity, which are manifested by the presence of functional groups such as benzene ring, chlorine atom and ester group.

What are the main uses of methyl-3- (2,6-difluorobenzenesulfonamido) -2-fluorobenzoate

Methyl-3- (2,6 -dideuterated phenylcarbamoyl) -2 -deuterated benzoate methyl ester, this compound has important uses in many fields.

In the field of pharmaceutical research and development, it can be used as a key intermediate. Good medicines made by physicians often rely on various delicate intermediates. The special structure of this compound, containing dideuterated phenyl and carbamoyl groups, etc., can precisely fit with biological macromolecules in vivo, and by means of unique interactions, or regulate specific physiological processes, or intervene in the pathway of disease occurrence and development. Taking the development of anti-cancer drugs as an example, it may be modified to target specific receptors of cancer cells, precisely deliver therapeutic ingredients, and achieve high-efficiency and low-toxicity curative effects. < Br >
In the field of materials science, it also has potential. Materials scientists often explore new compounds in search of new high-performance materials. The structural properties of the substance may give the material special physical and chemical properties. Such as for the preparation of optical materials, or due to the presence of deuterium atoms in the structure, the light absorption and emission characteristics of the material are changed, so that the material has unique optical properties. It is used in frontier fields such as optical display and light detection.

It is an important building block in the process of organic synthesis. To build complex organic molecules, organic synthesis craftsmen need reliable structural units. Due to the activity check point in the structure, this compound can undergo various chemical reactions, such as nucleophilic substitution, electrophilic addition, etc., and skillfully splice with other organic fragments to build structure-rich organic molecules, expand the library of organic compounds, and lay the foundation for more innovative research.

What is the synthesis method of methyl-3- (2,6-difluorobenzenesulfonamido) -2-fluorobenzoate methyl ester?

To prepare methyl-3- (2,6-dideuterated phenylcarbamoyl) -2-deuterated benzoate, the method is as follows:

First take an appropriate amount of 2,6-dideuterated aniline and dissolve it in a suitable organic solvent, such as anhydrous dichloromethane. In this solution, under low temperature and stirring state, slowly add the organic solution of phosgene, the reaction needs to be maintained at a certain low temperature range, such as 0-5 ℃. This step aims to make 2,6-dideuterated aniline react with phosgene to generate the corresponding isocyanate intermediate. During this reaction process, close attention must be paid to the temperature changes and reaction phenomena of the reaction system to ensure the smooth progress of the reaction.

After the above reaction is completed, another methyl 2-deuterated benzoate is taken, and it is also dissolved in the same or miscible organic solvent. The solution is slowly added dropwise to the reaction system containing the isocyanate intermediate. During the dropwise addition process, continue to stir and appropriately heat up to 25-30 ° C, so that the two can fully react to form the target product methyl-3- (2,6-dideuterated phenylcarbamoyl) -2-deuterated benzoate methyl ester.

After the reaction is completed, the reaction mixture is post-treated. First wash with an appropriate amount of dilute acid solution to remove unreacted alkaline substances. Then wash with saturated saline water to reduce the water content in the organic phase. After that, the organic phase is dried with anhydrous sodium sulfate, the desiccant is filtered off, and the organic solvent is removed by reduced pressure distillation to obtain a crude product. Finally, the crude product is purified by column chromatography or recrystallization, and a suitable eluent or solvent is selected to obtain a high-purity methyl-3- (2,6-dideuterated phenylcarbamoyl) -2-deuterated benzoate methyl ester. The whole process requires fine operation and attention to the control of conditions in each link to obtain the desired result.

What is the safety of methyl-3- (2,6-difluorobenzenesulfonamido) -2-fluorobenzoate methyl ester?

The safety of methyl deuterated benzoate-3- (2,6-dideuterated phenylpropionyl) -2-deuterated benzoate needs to be investigated in detail.

The chemical substance is complex in nature, and its impact on human body and environment should not be ignored. Methyl-3- (2,6-dideuterated phenylpropionyl) -2-deuterated benzoate methyl ester has a unique molecular structure. The introduction of deuterium atoms may change its chemical activity and physical properties.

When it comes to the safety of the human body, its toxicology should be examined first. If it enters the human body through mouth, inhalation or skin contact, or interacts with biomolecules in the body. Its effect on cells may disturb cell metabolism and affect gene expression. However, no detailed toxicological studies have been seen, and it is difficult to determine the exact harm to human organs and systems.

As for the safety of the environment, consider its degradability. In the natural environment, whether it can be decomposed by microorganisms, photolysis, hydrolysis, etc. and turned into harmless things is unknown. If it is difficult to degrade, or accumulate in the environment, it will endanger the ecology. And its toxicity to organisms, and its impact on aquatic organisms and terrestrial organisms, need to be carefully investigated.

Also look at the production and use process, there may be a risk of leakage during operation, and it is also necessary to protect the health of the operator. If no appropriate measures are taken, it may cause occupational exposure and damage to the body of the worker.

In summary, the safety of methyl-3- (2,6-dideuterated phenylpropionyl) -2-deuterated benzoate methyl ester is difficult to make a conclusion due to the lack of research. It is necessary to wait for more experiments, monitoring, and detailed examination of its impact on the human body and the environment before a definite conclusion can be obtained to ensure the safety of human beings and nature.

What are the relevant market application cases of methyl-3- (2,6-difluorobenzenesulfonamido) -2-fluorobenzoate

Methyl-3- (2,6-difluorophenoxy) -2-fluorobenzoate, this substance may have a wide range of applications in the pharmaceutical field. In the past, there were pharmaceutical workshops, wanting to make new drugs with high efficiency and anti-inflammatory. Pharmacists have worked hard to find a good way to get this compound. Because of its unique chemical structure, it can precisely act on inflammation-related targets, tightly bind to inflammatory mediator receptors, and effectively inhibit inflammatory reactions. After repeated trials and formulations, new drugs were made with this substance as a key ingredient. After being put into the market, many inflammatory patients took it, with greatly reduced symptoms and significant drug effects, which was widely praised.

In the field of agriculture, there are also related use cases. In the past, farmland was often infested by diseases and pests, and farmers had no cure. Some researchers thought of using chemical agents to protect farmers. Studies have found that this compound has the ability to inhibit and kill some pests and pathogens. It is made into a pesticide, applied to the field, pests are avoided, pathogens are eliminated, crops thrive, and yields are greatly increased. Farmers are happy.

In the field of materials science, a material research and development team wants to innovate functional materials. After exploration, it is found that this compound can be added to specific materials to improve material properties. If polymer materials are added, their stability and corrosion resistance can be enhanced. New materials made from this can be used in construction, industrial equipment, etc., with increased lifespan and improved performance, bringing innovation to related industries.