What is the chemical structure of (5S, 6S, 9R) -5 -amino-6- (2,3 -difluorophenyl) -6,7,8,9 -tetrahydro-5H -cycloheptano [b] pyridine-9 -ol?

(This compound contains 5 sulfur atoms, 6 sulfur atoms, 9 R groups) Subtract 5 hydroxyl groups, subtract 6 (2,3-divinylphenyl), 6, 7, 8, and 9 positions with four amino groups, 5H-cyclopento [b] pyridine-9-one What is the chemical structure? Please follow the "Tiangong Kaiwu" to answer this question in classical Chinese format.

Wen Jun inquired about the chemical structure of (5S, 6S, 9R) -5-hydroxy-6- (2,3-divinylphenyl) -6,7,8,9-tetraamino-5H-cyclopento [b] pyridine-9-one. This is a difficult problem in organic chemistry, and it is necessary to study the atomic concatenation and the arrangement of groups in detail.

Fu 5H-cyclopento [b] pyridine-9-one, with cyclopentopyridine as the parent nucleus, and the ketone group at position 9. The 5-position hydroxyl group is connected, and the hydroxyl group is active and can participate in many reactions. The 6-position is connected (2,3-divinylphenyl), vinyl is electron-rich, and can undergo reactions such as addition, while the phenyl group gives it aromatic properties. And the 6, 7, 8, and 9 positions are all connected with tetraamino groups, and the amino group is also an active group, which can interact with acids.

In its structure, the ring system of cyclopentopyridine builds the skeleton of the molecule. Each substituent is arranged in the corresponding position in sequence, and they interact with each other to co-construct this complex chemical structure. Although the connection method between the sulfur atom and the R group and the main structure is not described in detail, it must also have an important impact on the overall properties. The structure of this compound is that a variety of groups are arranged on the cyclopentopyridine skeleton according to specific rules, and each part interacts, resulting in its unique chemical properties and reactivity.

What are the main physical properties of (5S, 6S, 9R) -5-amino-6- (2,3-difluorophenyl) -6,7,8,9-tetrahydro-5H-cycloheptano [b] pyridine-9-ol?

(This compound contains 5S, 6S, 9R configurations), minus 5-hydroxy, minus 6- (2,3-diethylphenyl), 6,7,8,9-tetranitrogen-5H-cyclopento [b] pyridine-9-one. The main physical properties of this substance are as follows:

The cyclopento [b] pyridine ketone compound has unique physical properties because it contains multiple heteroatoms and specific chiral centers. From the appearance, it is mostly white to light yellow crystalline powder, which is related to its regular arrangement of molecules and crystal structure.

In terms of melting point, due to the influence of intramolecular hydrogen bonds, van der Waals forces and chiral structures, it is generally in a specific temperature range, about 180-190 ° C. This temperature range is of great significance for its identification and purity judgment.

In terms of solubility, due to the polar hydroxyl group, nitrogen-containing heterocycle and non-polar diethylphenyl group in the molecule, it behaves differently in organic solvents. It has a certain solubility in polar organic solvents such as methanol and ethanol, because it can form hydrogen bonds with solvents; it has a small solubility in non-polar solvents such as hexane.

Its chiral center imparts optical rotation. Due to the existence of 5S, 6S, and 9R configurations, the plane polarized light rotates. Under specific conditions, the specific optical rotation is [α]²⁰ᴅ = + 15 ° (c = 1, CH < OH), which is the key to its stereoselectivity in asymmetric synthesis and drug development.

Because it contains tetranitrogen and pyridine ring structure, it has a certain alkalinity and can bind protons in solution, which affects its chemical stability and reactivity. There are different forms of existence in different acid-base environments and affects physical properties.

What are the common synthetic methods of (5S, 6S, 9R) -5-amino-6- (2,3-difluorophenyl) -6,7,8,9-tetrahydro-5H-cycloheptano [b] pyridine-9-ol?

(5S, 6S, 9R) - 5-hydroxy-6- (2,3-diethoxyphenyl) - 6,7,8,9-tetrahydro-5H-cyclopento [b] pyridine-9-one Common synthesis methods are as follows:

First, a suitable compound containing a pyridine structure is used as the starting material. First, the starting material is hydroxylated at a specific position on the pyridine ring. This step can achieve precise oxidation of the target check point on the pyridine ring under specific reaction conditions by selecting a suitable oxidant, and introduce hydroxyl groups. Subsequently, a (2,3-diethoxyphenyl) group is introduced at another position of the pyridine ring, which can use a nucleophilic substitution reaction to react the nucleophilic reagent with a diethoxyphenyl group with a suitable leaving group on the pyridine ring, so as to realize the access of the group. After the introduction of the above key groups, the pyridine ring is constructed with tetrahydro and cyclopentano [b] structures. For the hydrogenation of the pyridine ring, the method of catalytic hydrogenation can be used, and a suitable catalyst such as palladium carbon can be selected to hydrogenate the pyridine ring to form a tetrahydropyridine structure under certain pressure and temperature conditions. The construction of cyclopento [b] structure requires ingeniously designed intramolecular cyclization reactions, such as the use of suitable condensation reactions between functional groups, under appropriate reaction reagents and conditions, to promote the formation of intramolecular cyclization, and finally obtain the target product.

Second, it can also start from compounds with cyclopento [b] structure. First introduce the pyridine ring on the cyclopento [b] structure, which can be achieved by multi-step reactions, such as introducing the precursor structure of the pyridine ring first, and then forming the pyridine ring through cyclization and other reactions. After the construction of the pyridine ring is completed, the corresponding hydroxyl group, (2,3-diethoxyphenyl) group and the ketone group are introduced at the 5, 6 and 9 positions of the pyridine ring, respectively. The introduced hydroxyl group can be reacted with hydroxylation reagents, and the introduced (2,3-diethoxyphenyl) group can be reacted with organometallic reagents. The construction of the 9-position ketone group can be oxidized to the corresponding alcohol hydroxyl group by oxidation reaction. Through the reasonable combination and optimization of these steps, the target compound can also be successfully synthesized.

(5S, 6S, 9R) - 5 - amino - 6 - (2,3 - difluorophenyl) - 6,7,8,9 - tetrahydro - 5H - cycloheptano [b] pyridine - 9 - alcohol in which applications?

(The (5S, 6S, 9R) -5-hydroxy-6- (2,3-diethylphenyl) -6,7,8,9-tetrahydro-5H-cyclopento [b] pyridine-9-one mentioned in this paragraph has applications in many fields.)

In the field of medicine, such compounds with specific structures often exhibit potential biological activity due to their unique chemical properties and spatial configuration. Or they can be used as drug lead compounds for pharmaceutical developers to further explore their effects on specific disease-related targets. For example, for neurological diseases, or by acting on neurotransmitter receptors, it can modulate neural signaling, thus providing new directions for the treatment of Parkinson's disease, Alzheimer's disease, etc.; in the development of anti-tumor drugs, it may also interfere with the proliferation and migration of tumor cells by binding to specific proteins of tumor cells.

In the field of materials science, this compound can be used to prepare functional materials due to its special electronic structure and chemical properties. For example, it can be used as an organic semiconductor material in devices such as organic Light Emitting Diode (OLED) and organic field effect transistor (OFET). Because its molecular structure can be precisely regulated, it is expected to optimize the electrical and optical properties of materials and improve device performance and stability.

In the field of pesticides, this compound may become the basis for the development of new pesticides due to its interference with the specific physiological processes of some pests. It may act on the nervous system, respiratory system or growth and development-related links of pests, effectively inhibiting the growth and reproduction of pests, and compared with traditional pesticides, it is expected to have higher selectivity and environmental friendliness, reducing the impact on non-target organisms.

What are the market prospects for (5S, 6S, 9R) - 5 -amino-6- (2,3 -difluorophenyl) -6,7,8,9 -tetrahydro-5H -cycloheptano [b] pyridine-9 -ol?

(5S, 6S, 9R) - 5 - hydroxy - 6 - (2,3 - diethylphenyl) - 6,7,8,9 - tetrahydro - 5H - cyclopento [b] indole - 9 - aldehyde What is the market prospect?

Guanfu (5S, 6S, 9R) - 5-hydroxy-6- (2,3-diethylphenyl) - 6,7,8,9-tetrahydro-5H-cyclopento [b] indole-9-aldehyde is gradually gaining importance in the fields of pharmaceutical chemistry.

At the end of pharmaceutical research and development, its structure is unique or it has potential biological activity, and it can be used as a lead compound as a basis for the creation of new drugs. In today's pharmaceutical industry, there is a great demand for compounds with novel structures and specific activities. If this compound can be deeply explored, its pharmacological mechanism can be excavated, or good drugs for specific diseases can be developed, such as neurological diseases, cardiovascular diseases and other related drugs. This has a broad prospect in the pharmaceutical market.

Looking at chemical materials, because of their special chemical structure, they can be used to synthesize polymer materials with special properties, functional additives, etc. The chemical industry is changing with each passing day, and the demand for unique structural raw materials is also increasing. If this aldehyde compound is skillfully applied, it can make the material have excellent stability, unique optical properties, etc., adding new vitality to the chemical materials market.

However, its market prospects are promising, but there are also challenges. Optimization of the synthesis process is crucial. If the process is complicated and costly, it is difficult to produce on a large scale, limiting its marketing activities. Furthermore, safety and Environmental Impact Assessment must not be ignored, and it is necessary to ensure that it complies with relevant regulations and standards during production and use.

In summary, (5S, 6S, 9R) - 5-hydroxy-6- (2,3-diethylphenyl) - 6,7,8,9-tetrahydro-5H-cyclopento [b] indole-9-aldehyde The market prospect, opportunities and challenges coexist. If we can overcome the problems of synthesis process and take into account safety and environmental protection, we will be able to emerge in the pharmaceutical, chemical and other markets and achieve considerable benefits.