What is the main use of (4-butoxy-2,3-difluorophenyl) boronic acid?

(4-butoxy-2,3-difluorophenyl) boric acid is a key raw material for organic synthesis. It has a wide range of uses and is often used as a building block for complex drug molecules in the field of medicinal chemistry. Because boron atoms have unique electronic properties, they can participate in various chemical reactions and help to accurately construct the active structure of drugs, so they are indispensable for the creation of new drugs.

In the field of materials science, (4-butoxy-2,3-difluorophenyl) boric acid is also highly valued. It can be used to prepare functional organic materials, such as optoelectronic materials. By ingeniously designing and combining with other organic groups, the photoelectric properties of materials can be regulated, which contributes to the research and development of Light Emitting Diodes, solar cells and other devices.

In organic synthetic chemistry, this boric acid is often used as a key reagent in the Suzuki-Miyaura coupling reaction. This reaction can efficiently form carbon-carbon bonds and greatly expand the structural diversity of organic molecules. With this reaction, chemists can combine (4-butoxy-2,3-difluorophenyl) boric acid with various halogenated or pseudo-halogenated hydrocarbons to synthesize many organic compounds with novel structures and unique properties, which are of great significance in the total synthesis of natural products and the creation of new materials. In short, (4-butoxy-2,3-difluorophenyl) boric acid plays a pivotal role in many scientific research and industrial fields due to its unique chemical properties.

What are the physical properties of (4-butoxy-2,3-difluorophenyl) boronic acid

(4-butoxy-2,3-difluorophenyl) boric acid is an important compound in organic chemistry. Its physical properties are of great value for investigation.

First of all, its appearance is often white to white solid powder, which is easy to store and use. It can exist stably in many chemical reactions, providing a stable starting material for subsequent reactions.

and its melting point, (4-butoxy-2,3-difluorophenyl) boric acid has a specific melting point range, which is of great significance for identifying the compound and controlling the reaction process. Covered in chemical synthesis, the melting point is often one of the key indicators for judging the purity of the compound. If the purity of the compound is high, the melting point is sharp and close to the theoretical value; if it contains impurities, the melting point tends to decrease and the melting range becomes wider.

Furthermore, solubility is also one of its important physical properties. In common organic solvents such as ethanol and ether, the boric acid exhibits a certain solubility. This property makes it possible to participate in various organic reactions in the corresponding solvent system, such as coupling reactions. By selecting a suitable solvent, the reaction rate and product selectivity can be adjusted. In water, its solubility is relatively limited, but it also determines its behavior in some reactions or separation processes involving the aqueous phase.

In addition, although the density of this compound is not always of concern, it is necessary to consider it in specific industrial production or experimental operations. Accurate density data helps to accurately measure the material, thereby ensuring the accuracy and repeatability of the reaction.

The physical properties of (4-butoxy-2,3-difluorophenyl) boric acid, such as appearance, melting point, solubility, density, etc., are interrelated and affect its application in the field of chemistry. It plays an indispensable role in organic synthesis, materials science and many other aspects.

What are the synthesis methods of (4-butoxy-2,3-difluorophenyl) boronic acid

The method of synthesizing (4-butoxy-2,3-difluorophenyl) boric acid is often involved in the field of organic synthesis. To obtain this compound, there are two common methods.

First, the halogenated aromatic hydrocarbon is used as the starting material. First, take 4-halogenated-2,3-difluoroanisole, the halogen atom can be bromine or iodine, and undergo a nucleophilic substitution reaction with butanol in the presence of a base to form 4-butoxy-2,3-difluoroanisole. Afterwards, it is subjected to a lithium-halogen exchange reaction and treated with n-butyl lithium and other reagents to generate the corresponding lithium reagent. Then the lithium reagent is reacted with borate esters, such as trimethyl borate, and hydrolyzed to obtain (4-butoxy-2,3-difluorophenyl) boric acid. The key to this path is that the lithium-halogen exchange reaction needs to be carried out under harsh conditions of low temperature and no water and no oxygen to ensure the smooth reaction. The control of the conditions of each step of the reaction is very important. The activity of halogenated aromatics, the type and dosage of bases, the reaction temperature and time will all affect the yield and purity.

Second, synthesized by Grignard reagent method. The Grignard reagent is prepared by reacting 4-halogenated-2,3-difluoroanisole with magnesium chips in anhydrous ether or tetrahydrofuran. The Grignard reagent has high activity, and then reacts with borate esters, such as triisopropyl borate, and then acid hydrolyzes to obtain the target product. Although this method is slightly broader than the former conditions, the preparation of Grignard reagents also requires an anhydrous environment, and the selection of halogenated aromatics, the quality of magnesium chips, and the drying degree of the solvent all have a profound impact on the reaction. During the synthesis process, the reaction intermediates and products need to be separated and purified. The commonly used methods include column chromatography and recrystallization to ensure that the purity of the product meets the required standards.

(4-butoxy-2,3-difluorophenyl) boronic acid is commonly used in which chemical reactions

(4-butoxy-2,3-difluorophenyl) boric acid, a commonly used reagent in organic synthesis, has important applications in many chemical reactions.

In the carbon-carbon bond formation reaction, it is often found in the Suzuki coupling reaction. In this reaction, (4-butoxy-2,3-difluorophenyl) boric acid can be successfully coupled with halogenated aromatics or olefins under the action of palladium catalysts and bases to form biaryl or alkenyl aromatics with specific structures. Such compounds are widely used in the fields of drug synthesis and materials science, such as the synthesis of key structural units of new drug molecules, or the preparation of materials with special optoelectronic properties.

It also plays a role in the formation of carbon-heteroatomic bond reactions. For example, when reacting with nucleophiles containing nitrogen, oxygen, sulfur and other heteroatoms, compounds containing carbon-heteroatomic bonds can be formed. Such reactions often play a key role in the synthesis of biologically active heterocyclic compounds and functionalized polymers.

In some functional group conversion reactions, (4-butoxy-2,3-difluorophenyl) boric acid can participate in oxidation, reduction and other reactions due to the characteristics of boron atoms, and then realize the conversion and modification of functional groups. This provides chemists with more strategies and options in the design and optimization of organic synthesis routes, which can help synthesize organic compounds with more complex structures and specific functions.

What is the market price of (4-butoxy-2,3-difluorophenyl) boronic acid

(4-butoxy-2,3-difluorophenyl) boric acid, the price of this product in the market is difficult to determine. The price often changes due to various reasons.

First, the source of production is essential. If there are many producers, the supply is sufficient, the price may be flat, or even drop. However, the production is thin, the output is small, and the supply is not enough, the price will be easy to rise.

Second, the quality of the quality is also related to the price. If the product is high in purity, the impurities are rare, and it meets all kinds of strict regulations, the price should be high; if the quality is impure, the price will be low.

Third, the purchase quantity is different, and the price is also different. If the purchase quantity is low, the merchant often gives a discount, and the price is good for large quantities to promote more sales; if the purchase quantity is small, the price may not be compromised.

Fourth, the demand of the market also affects the price. In the fields of chemical industry and pharmaceutical research and development, if the (4-butoxy-2,3-difluorophenyl) boric acid needs Yin, the price will increase; if it needs to be light, the price will either stabilize or decrease.

According to past market conditions, the price of this product per gram can range from tens of gold at least to hundreds of gold at most. However, the market conditions are ever-changing, and today's price cannot be determined. To know the real-time price, it is advisable to consult chemical raw material suppliers, reagent suppliers, or explore the chemical product trading platform in order to obtain the exact number.