What is the main use of 4,4-difluoro-N- [ (1S) -3-hydroxy-1-phenylpropyl] cyclohexane formamide

The use of 4,4-diene-N-[ (1S) -3-methoxy-1-naphthyl ethyl] cyclohexanecarbonamide is based on the ancient style of "Tiangong Kaiwu".

This compound may have extraordinary uses in the field of medicine. Due to the unique molecular structure, it may interact with specific targets in organisms, like tenon and mortise. In the process of drug development, it may be used as a lead compound to help doctors create novel drugs to cure various diseases. For example, through fine research and modification, it may be able to act on the signaling pathway of the human body, and provide precise treatment for diseases caused by signal transduction disorders, such as tumors and metabolic disorders.

Furthermore, in the field of organic synthesis, it can also be a key intermediate. The wonders of organic synthesis, such as craftsmen building buildings, are constructed layer by layer from various basic raw materials to form complex and delicate molecules. With its special structure, this compound can guide the direction of the reaction in the synthesis reaction and build a more complex and unique organic molecular structure, paving the way for the synthesis of new materials, fine chemicals, etc.

Or in the journey of scientific research and exploration, as an important sample to study the relationship between biological activity and structure. Scientists can analyze it in depth to find out how the subtle changes in structure lead to differences in biological activity, and then gain insight into the mysteries of life processes, contributing to the development of life science, just like wise men in the vast sea of knowledge, exploring the unknown.

What are the synthesis methods of 4,4-difluoro-N- [ (1S) -3-hydroxy-1-phenylpropyl] cyclohexane formamide

To prepare 4,4-diene-N- [ (1S) -3-cyano-1-phenylethyl] cyclohexanecarbonamide, the method is as follows:
First, a suitable starting material can be used to introduce 4,4-diene structure through alkylation. The method of alkylation is usually Wittig reaction or Horner-Wadsworth-Emmons reaction. Here, a suitable phosphonylide or phosphonate ester reagent is selected, and the carbonyl-containing raw material can be catalyzed by a base to form a carbon-carbon double bond to obtain an intermediate with 4,4-diene. Next, the N - [ (1S) -3 -cyano-1 -phenylethyl] moiety is to be introduced. (1S) -3 -cyano-1 -phenylethylamine can be prepared first, which can be obtained from optically active starting materials through several steps. Then, the amine is amidated with 4,4 -diene intermediates containing carboxyl groups or their active derivatives (e.g. acid chloride, acid anhydride). During amidation, a condensing agent such as dicyclohexyl carbodiimide (DCC) and a catalyst of 4-dimethylaminopyridine (DMAP) are used to promote the reaction to proceed efficiently to obtain the target product 4,4-diene-N- [ (1S) -3-cyano-1-phenylethyl] cyclohexanecarbamide.
Or, another way. First, a nitrogen-containing reagent is reacted with a suitable halogen to construct a fragment containing N - [ (1S) -3 -cyano-1 -phenylethyl], and then the fragment is connected to a cyclohexane derivative with 4,4 -diene. The method of linking, or the coupling reaction catalyzed by transition metals, such as the Buchwald-Hartwig amination reaction catalyzed by palladium, to achieve the synthesis of the target molecule. This method requires careful selection according to the availability of raw materials, the difficulty of reaction conditions and the yield.

What are the physical properties of 4,4-difluoro-N- [ (1S) -3-hydroxy-1-phenylpropyl] cyclohexane formamide

4,4-Diene-N- [ (1S) -3-methoxy-1-phenylethyl] cyclohexanecarbonamide, which is an organic compound. Its physical properties are as follows:

Looking at its morphology, it is a white to light yellow solid at room temperature and pressure, but its exact color state may vary slightly due to the purity and preparation method.

When it comes to melting point, the intermolecular forces vary due to the structure within the molecule, and the melting point is about a specific temperature range. Sadly, due to lack of detailed data, it is difficult to determine its specific value. However, the melting point of such compounds containing amide structures has a certain range, which can be accurately determined by experiments.

Its solubility is due to the fact that there are both hydrophobic benzene ring, cyclohexyl group and other groups in the molecule, as well as hydrophilic amide groups. In organic solvents, such as dichloromethane, chloroform, tetrahydrofuran, etc., or show a certain solubility. This is due to the interaction between hydrophobic groups and organic solvents, which helps them to dissolve. In water, although amide groups can form hydrogen bonds with water, the existence of hydrophobic groups may cause their water solubility to be poor, only slightly soluble or insoluble. < Br >
Its density is also related to the molecular structure and composition. The relative mass and spatial arrangement of carbon, hydrogen, oxygen, nitrogen and other atoms in the molecule determine its density. However, the exact density value needs to be accurately measured by experimental means, such as the specific gravity bottle method.

In addition, the compound may have certain stability. However, under specific conditions, such as high temperature, strong acid, and strong alkali environment, the structure of amide bonds in the molecule may change, resulting in changes in the properties of the compound.

What are the chemical properties of 4,4-difluoro-N- [ (1S) -3-hydroxy-1-phenylpropyl] cyclohexane formamide

4,4-Diene-N- [ (1S) -3-methoxy-1-naphthyl ethyl] cyclohexanecarbonamide has the following chemical properties:
Its molecule contains a conjugated diene structure. Due to the conjugation system, it exhibits unique electron delocalization characteristics, which endows the compound with high reactivity. In the electrophilic addition reaction, the conjugated diene can react efficiently with electrophilic reagents such as hydrogen halide and halogen. Taking the reaction with bromine as an example, 1,2-addition and 1,4-addition products can be generated, depending on the reaction conditions. Under the conditions of low temperature and polar solvents, 1,2-addition products are the main ones; in high temperature or non-polar solvents, 1,4-addition products are mostly.

Molecular lactam bonds are also key structures. The amide bond has a certain stability, but it will break in the hydrolysis reaction catalyzed by acid or base. In acidic media, amides are hydrolyzed to form carboxylic acids and amine salts; in alkaline environments, carboxylic salts and amines are formed. This property is of great significance in organic synthesis and drug metabolism.

In addition, aromatic substituents such as naphthyl and methoxy in the molecule are prone to electrophilic substitution reactions due to aryl π electron clouds. Methoxy group is an ortho-para localization group, which can increase the density of aromatic ring electron cloud in the ortho-para, which prompts electrophilic reagents to preferentially attack the ortho-para, and then electrophilic substitution reactions such as halogenation, nitration, and sulfonation occur.

And the chiral center (1S) imparts optical activity to the compound. In asymmetric synthesis and enantioselectivity reactions, the chiral structure affects the interaction between the compound and other chiral substances, and different enantiomers may exhibit very different biological activities and physical properties.

What are the relevant safety considerations for 4,4-difluoro-N- [ (1S) -3-hydroxy-1-phenylpropyl] cyclohexane formamide?

4,4-Diene-N- [ (1S) -3 -methoxy-1-naphthyl ethyl] cyclohexanecarbonamide, which is an extremely complex organic compound. Regarding its safety precautions, let me elaborate.

First, the chemical properties are special and the stability is questionable. Or under specific conditions, in case of high temperature, open flame, strong oxidant, etc., it is easy to cause chemical reactions, and even cause the risk of combustion and explosion. Therefore, when storing, be sure to store it in a cool, well-ventilated place, away from fire and heat sources, and separately from oxidants, and must not be mixed.

Second, toxicity is unknown. Although there is no exact toxicity data, many organic compounds are potentially toxic. Contact with them, or through inhalation, ingestion, skin absorption, etc., can cause damage to the human body. Or cause respiratory irritation, causing coughing, asthma; or damage the skin, causing redness, swelling, itching; or harm the digestive system, causing nausea, vomiting and other diseases. During operation, when taking strict protective measures, wear protective clothing, protective gloves and gas masks to avoid direct contact.

Third, environmental impact. If accidentally leaked into the environment, or cause pollution to water, soil, air. Because of its complex structure, or difficult to degrade, long-term residue, endangering the ecological balance. In the event of a leak, emergency measures should be taken promptly to contain and collect, avoid spread, and properly dispose of the leak.

Fourth, transportation needs to be cautious. Due to latent risks, it is necessary to ensure that the packaging is intact during transportation, anti-collision and anti-leakage. According to relevant regulations, choose suitable transportation tools, and transport personnel should be familiar with emergency treatment methods.

Operating 4,4-diene-N - [ (1S) -3-methoxy-1-naphthyl ethyl] cyclohexanecarbonamide, when extremely careful, strictly abide by safety procedures to protect their own safety and protect the environment from harm.