What is the chemical structure of (2R) 2- (2,4-difluorophenyl) -1,1-difluoro-1- {5- [4- (2,2,2-trifluoroethoxy) phenyl] pyridine-2-yl} -3- (1H-tetrazole-1-yl) propyl-2-ol

(2R) 2- (2,4-difluorophenyl) -1,1-difluoro-1- {5- [4- (2,2,2-trifluoroethoxy) phenyl] pyridine-2-yl} -3- (1H-tetrazole-1-yl) propyl-2-ol, this is an organic compound. To clarify its chemical structure, it is necessary to first analyze the meaning of each group.

" (2R) " indicates that the chiral central configuration of the compound is R type. "2- (2,4-difluorophenyl) " means that there is 2,4-difluorophenyl at the second position of the main chain. "1,1-difluoro" indicates that there are two fluorine atoms at the first position of the main chain. " 1- {5- [4- (2,2,2-trifluoroethoxy) phenyl] pyridine-2-yl} "means that a complex group is connected at the first position of the main chain, which contains a pyridine ring, and the 5 position of the pyridine ring is connected with a structure modified by 4- (2,2,2-trifluoroethoxy) phenyl." 3- (1H-tetrazole-1-yl) "shows that the third position of the main chain is connected with 1H-tetrazole-1-yl. The main chain of the" propyl-2-ol "table is a propanol structure containing three carbons, and the hydroxyl group is connected to the second carbon.

According to the ancient text of" Tiangongkai ", its structure is as follows: there is a compound with a unique shape. Its chirality is set to " (2R) ", indicating a unique structure. On the main chain, the two-position is connected to the difluorophenyl group, which is like a branch. The first is difluoride, which increases its characteristics. There is also a pyridine ring, the five-position on the ring is connected to the modified phenyl group, and the phenyl group is trifluoroethoxy. The main chain is three-position, even the tetrazole group. The main chain is in the shape of propanol, and the hydroxyl group is in the two-position carbon. Such a structure is complex and delicate, and contains chemical wonders.

What are the physical properties of (2R) 2- (2,4-difluorophenyl) -1,1-difluoro-1- {5- [4- (2,2,2-trifluoroethoxy) phenyl] pyridine-2-yl} -3- (1H-tetrazole-1-yl) propyl-2-ol

(2R) 2- (2,4-dienobenzyl) -1,1-diene-1- {5- [4- (2,2,2-trifluoroethoxy) benzyl] pyridine-2-yl} -3- (1H-tetrazole-1-yl) propyl-2-ol is a complex organic compound. The properties of this compound are diverse, and the consideration of its properties needs to be comprehensive.

Looking at its structure, this compound has certain reactivity due to the presence of multiple unsaturated bonds and specific functional groups. The carbon-carbon double bond contained in it can participate in addition reactions, such as electrophilic addition. The electron cloud density of olefin double bonds is high, and it is vulnerable to electrophilic attack, such as addition to hydrogen halides and halogens, etc., thereby changing the molecular structure and properties.

Furthermore, the introduction of fluorine atoms will significantly affect the electron cloud distribution and polarity of molecules due to the large electronegativity of fluorine atoms. The 2,2,2-trifluoroethoxy moiety endows molecules with unique physical and chemical properties, such as enhanced lipid solubility. Due to the special properties of fluorine atoms, compounds are more soluble in non-polar or weakly polar organic solvents. This property may affect their absorption and distribution in vivo.

1H-tetrazole-1-yl functional group also has characteristics. The tetrazole ring has certain acidity, can participate in acid-base reactions, and can form complexes with metal ions. This property may have applications in the field of medicinal chemistry and materials chemistry, such as for the design of metal complex drugs or the construction of functional materials.

As a common nitrogen-containing heterocycle, pyridyl groups are basic and can react with acids to form salts, changing the solubility and stability of compounds. It also affects the overall electron conjugation system in molecules, and has potential effects on the optical and electrical properties of compounds.

This compound exhibits rich physical and chemical properties due to its complex structure and diverse functional groups, and may have broad application prospects in the fields of organic synthesis, drug development, materials science, etc. It can be used as an intermediate for the synthesis of more complex compounds, or based on its properties to develop new drugs and functional materials.

What is the synthesis method of (2R) -2- (2,4-difluorophenyl) -1,1-difluoro-1- {5- [4- (2,2,2-trifluoroethoxy) phenyl] pyridine-2-yl} -3- (1H-tetrazole-1-yl) propyl-2-ol

To prepare (2R) - 2 - (2,4 - difluorophenyl) - 1,1 - difluoro - 1 - {5 - [4 - (2,2,2 - trifluoroethoxy) phenyl] pyridine - 2 - yl} - 3 - (1H - tetrazole - 1 - yl) propyl - 2 - one, the following ancient method can be used.

Take 2,4 - difluorobenzaldehyde first and make it react with (R) - epoxy chloropropane catalyzed by alkali. The base can be selected from potassium hydroxide or the like, and stirred in a suitable solvent, such as dichloromethane, at a controlled temperature. This step aims to open the epoxy ring of epoxy chloropropane and connect it with 2,4-difluorobenzaldehyde to obtain an intermediate containing hydroxyl groups and halogen atoms.

Then, the intermediate is coupled with 5- [4- (2,2,2-trifluoroethoxy) phenyl] pyridine-2-boronic acid for Suzuki (Suzuki) coupling reaction. A palladium catalyst, such as tetra (triphenylphosphine) palladium, is required to react in a basic environment in a mixed solvent of toluene-ethanol-water. In this step, the pyridine-phenyl fragment can be connected to obtain another key intermediate.

Subsequently, the intermediate is reacted with sodium azide, and the halogen atom is replaced by an azide group through nucleophilic substitution. The reaction is carried out in a suitable solvent, such as dimethylformamide (DMF). After heating and other conditions, the azide is cyclized to form 1H-tetrazole-1-yl, and the tetrazolyl-containing intermediate is obtained.

Finally, the intermediate is carbonylated. Under the atmosphere of carbon monoxide, catalyzed by palladium catalyst, under suitable solvent and basic conditions, the terminal halogen atom can be replaced by carbonyl group, and finally (2R) - 2 - (2,4 - difluorophenyl) - 1,1 - difluoro - 1 - {5 - [4 - (2,2,2 - trifluoroethoxy) phenyl] pyridine - 2 - yl} - 3 - (1H - tetrazole - 1 - yl) propyl - 2 - one. After each step of the reaction, separation and purification methods, such as column chromatography and recrystallization, are required to extract the purity of the product and advance the synthesis process one by one.

(2R) 2- (2,4-difluorophenyl) -1,1-difluoro-1- {5- [4- (2,2,2-trifluoroethoxy) phenyl] pyridine-2-yl} -3- (1H-tetrazole-1-yl) propyl-2-ol What are the application fields

The name of this compound is complex, and its application fields are as follows: In the field of organic synthesis, due to its unique structure, (2R) -2 - (2,4 - difluorophenyl) -1,1 - difluoro-1 - {5 - [4 - (2,2,2 - trifluoroethoxy) phenyl] pyridine-2 - yl} -3 - (1H - tetrazole-1 - yl) propyl-2 - ene can be used as a key intermediate. Through specific chemical reactions, the active groups such as fluorine atoms, pyridyl groups, and tetrazolyl groups contained in it are used to react with other organic reagents for substitution, addition, etc., to construct more complex organic molecular structures, which are used to synthesize organic materials or drug lead compounds with specific functions.

In the field of pharmaceutical chemistry, the special structure of this compound endows it with potential biological activity. The fluorine atoms in it can enhance the lipid solubility of the compound, help it penetrate biological membranes, and improve bioavailability. Pyridyl and tetrazolyl can interact with specific targets in organisms, such as proteins, enzymes, etc., and have the potential to be developed as drugs for the treatment of specific diseases, such as the development of innovative drugs for certain inflammation-related diseases, nervous system diseases or tumors. < Br >
In the field of materials science, this compound can be used to prepare materials with special properties. For example, as a functional additive, it can be added to polymer materials to improve the electrical, optical or thermal properties of the materials with its structural properties, and prepare high-performance materials suitable for electronic devices, optical instruments and other fields.

What is the market prospect of (2R) 2- (2,4-difluorophenyl) -1,1-difluoro-1- {5- [4- (2,2,2-trifluoroethoxy) phenyl] pyridine-2-yl} -3- (1H-tetrazole-1-yl) propyl-2-ol?

"Tiangong Kaiwu" contains: " (2R) - 2 - (2,4 - difluorophenyl) - 1,1 - difluoro - 1 - {5 - [4 - (2,2,2 - trifluoroethoxy) phenyl] pyridine - 2 - yl} - 3 - (1H - tetrazole - 1 - yl) propane - 2 - ene, what is the city scene like?"

This is a fine chemical substance. In today's chemical industry, it is mostly involved in pesticides and medicine. If we describe its city scene in an ancient saying, it can be said that in today's world, chemical industry is flourishing, and all kinds of new products are competing. This (2R) -2- (2,4-difluorophenyl) -1,1-difluoro-1- {5 - [4- (2,2,2-trifluoroethoxy) phenyl] pyridine-2-yl} -3- (1H-tetrazole-1-yl) propylene-2-ene, because of its unique structure, is used in agriculture and medicine, and has different functions.

Together with pesticides, it can produce highly effective insecticides and bacteriostatic agents, protect farmers and mulberry crops, and protect them from pests and pathogens. Therefore, in the market of agricultural protection, the demand is growing. Farmers seek its strong effect to protect the things in the field, and merchants are also competing to sell such good products. The market trade is quite prosperous.

In the field of medicine, researchers explore its pharmacology, hoping to make new agents to treat various diseases in the world. Although it is still in the process of research, its potential is obvious. All doctors and pharmaceutical companies are paying attention to this, hoping to have new gains to benefit the world. Therefore, it is also expected by the public in the market of pharmaceutical research and development, and the prospect is promising. Overall, this substance is in a state of vigorous development in the current market scene, and may become an important tool in the field of agricultural medicine in the future.