What is the chemical structure of (2R) -1- (2,4-difluorophenyl) -2- (((tetrahydro-2H-pyran-2-yl) oxy) propyl-1-one?

The chemical structure of (2R) -1- (2,4-difluorophenyl) -2- (((tetrahydro-2H-pyran-2-yl) oxy) propyl-1-ol is just like the exquisitely constructed miniature world, composed of various atoms arranged in a specific order.

In this compound, (2R) indicates the configuration of its chiral center, which is a key stereochemical property, like a pointer that determines the "direction" of the microscopic world of matter. 1- (2,4-difluorophenyl), visible above the benzene ring, is cleverly connected with fluorine atoms at positions 2 and 4. The benzene ring is a stable skeleton of this microstructure. The introduction of fluorine atoms gives it different electronic effects and spatial properties.

And 2- ((tetrahydro-2H-pyran-2-yl) oxy) part, tetrahydro-2H-pyran-2-yl is a cyclic structure containing oxygen, which is connected to the main chain with oxygen atoms as a bridge, just like a unique ring hanging on the main skeleton, which affects the solubility, stability and interaction mode of the whole molecule with other molecules. The propyl-1-ol part is based on a chain of three carbon atoms and is connected at one end with a hydroxyl group. Hydroxyl is a group with active chemical properties, which can participate in many chemical reactions, such as esterification, oxidation, etc., adding reactivity to the whole molecule.

The components are interconnected to form a unique three-dimensional chemical structure, and the bonding, bond length, and bond angle between the atoms are all accurate, giving this compound specific physical and chemical properties. It may play a unique and important role in organic synthesis, pharmaceutical chemistry, etc., or can be used as a key building block for constructing more complex active molecules, or exhibit unique pharmacological activities in drug development.

What are the main uses of (2R) -1- (2,4-difluorophenyl) -2- (((tetrahydro-2H-pyran-2-yl) oxy) propyl-1-one?

(2R) -1- (2,4-dichlorophenyl) -2- ((tetrahydro-2H-pyran-2-yl) oxy) propyl-1-ol, this compound has important uses in the field of medicinal chemistry.

In the process of pharmaceutical research and development, it can be used as a key intermediate. For example, when creating new antifungal drugs, with its unique chemical structure, it can closely fit with fungal specific targets and interfere with the normal physiological processes of fungal cells, such as cell wall synthesis, cell membrane function maintenance, etc., and then exhibit significant antifungal activity, providing effective drug options for combating fungal infections.

In the field of organic synthesis, it is also an extremely important building block. Because of its multiple modifiable check points, chemists can delicately carve its structure through various chemical reactions, such as substitution reactions, addition reactions, etc., to derive a series of structurally distinct and functionally diverse compounds, which greatly enriches the types of organic compounds and lays a solid foundation for the exploration of new bioactive substances.

In addition, in pharmaceutical chemistry research, the structure optimization and modification of the compound can be deeply explored structure-activity relationship. By fine-tuning its substituents, observing the changes in activity and selectivity, it can guide the design of more efficient and low-toxicity drugs, and promote the development of new drugs to a higher level.

What are the synthesis methods of (2R) -1- (2,4-difluorophenyl) -2- (((tetrahydro-2H-pyran-2-yl) oxy) propyl-1-one?

The synthesis of (2R) -1- (2,4-dichlorophenyl) -2- ((tetrahydro-2H-pyran-2-yl) oxy) propyl-1-ol is an important topic in the field of organic synthesis. This compound often plays a key role in the preparation of medicine and other fine chemicals. There are many synthesis methods, the following are common ones:

First, a suitable halogenated hydrocarbon is used as the starting material. First, the halogenated hydrocarbon undergoes a nucleophilic substitution reaction with 2,4-dichlorobenzene to generate the corresponding substituted benzene derivatives. Subsequently, the derivative was etherified with tetrahydro-2H-pyran-2-ol under alkali catalysis, and (tetrahydro-2H-pyran-2-yl) oxygen was introduced. Finally, the obtained product was reduced by a suitable reducing agent to obtain the target product (2R) -1- (2,4-dichlorophenyl) -2- ((tetrahydro-2H-pyran-2-yl) oxy) propyl-1-ol. This path requires careful selection of halogenated hydrocarbons and reaction conditions to ensure the selectivity and yield of the reaction. < Br >
Second, the Grignard reagent method can be used. First, 2,4-dichlorophenyl Grignard reagent is prepared, and it reacts with suitable carbonyl compounds to form carbon-carbon bonds and generate corresponding alcohol derivatives. After that, the hydroxy protecting group strategy is used to form (tetrahydro-2H-pyran-2-ol) oxygen protecting group with tetrahydro-2H-pyran-2-yl) alcohol. Finally, through the deprotection reaction, the target product is obtained. In this method, the preparation of Grignard reagent and the control of reaction conditions are extremely important, otherwise side reactions are easy to occur.

Third, the enol ether method can also be used. The intermediate containing the enol ether structure is first synthesized, and the benzene ring structure is introduced after addition reaction with 2,4-dichlorobenzene. Then, the enol ether is hydrolyzed to generate the corresponding alcohol. Then it is reacted with tetrahydro-2H-pyran-2-alcohol to form the ether structure of the target product. This approach needs to pay attention to the stability of the enol ether and the selectivity of the addition reaction.

Each synthesis method has its own advantages and disadvantages. In practical applications, it is necessary to comprehensively consider the availability of raw materials, the difficulty of controlling the reaction conditions, the cost and the purity requirements of the target product, and carefully select the appropriate synthesis route.

What are the physical properties of (2R) -1- (2,4-difluorophenyl) -2- (((tetrahydro-2H-pyran-2-yl) oxy) propyl-1-one?

(This paragraph names complex organic compounds, and it is impossible to clarify the specific properties of the corresponding substances for the time being. It is only speculated from the perspective of general organic compounds.) This is (2R) -1- (2,4-diethylphenyl) -2 - ((tetrahydro-2H-pyran-2-yl) oxy) propyl-1 -ol. Organic alcohols, containing ether bonds and aryl groups. Its physical properties are as follows:
Mostly liquid at room temperature, can form hydrogen bonds due to hydroxyl groups, and its boiling point is higher than that of hydrocarbons of the same molecular weight. Hydrophobic, containing hydrocarbons, with limited solubility in water, or soluble in common organic solvents such as ethanol and ether. The hydroxy group has a certain polarity, which has an effect on its distribution coefficient in different solvents. The molecule contains chiral carbon, which has optical rotation. Different optical isomers may have different rotation directions and degrees to polarized light. Aryl groups give certain stability and special optical properties. Tetrahydropyran ring affects the spatial structure and chemical environment, or fine-tunes its melting point, boiling point and solubility. Due to the complex structure, the actual physical properties may be influenced by factors such as the position and spatial arrangement of the substituents, and it needs to be accurately determined by experiments.

What are the market prospects for (2R) -1- (2,4-difluorophenyl) -2- (((tetrahydro-2H-pyran-2-yl) oxy) propyl-1-one?

(2R) -1- (2,4-dichlorophenyl) -2- ((tetrahydro-2H-pyran-2-yl) oxy) propyl-1-ol, a fine chemical with key uses in the fields of medicine and pesticides.

Looking at its market prospects, in the pharmaceutical industry, with the deepening of research on specific diseases, the demand for drugs made from this key intermediate may be on the rise. Taking some antifungal drugs as an example, (2R) -1- (2,4-dichlorophenyl) -2- ((tetrahydro-2H-pyran-2-yl) oxy) propyl-1-ol is an indispensable raw material. With the fluctuation of the incidence of fungal infections, the market demand for it as an upstream raw material also fluctuates.

In the field of pesticides, with the advancement of the research and development process of green and high-efficiency pesticides, the quality and purity requirements of such fine chemicals are increasingly stringent. If it can meet the double standards of environmental protection and high efficiency, with its unique chemical properties in pesticide synthesis, it can give pesticides better biological activity and stability, and the market potential is considerable.

However, the market also faces challenges. On the one hand, the complexity of the synthesis process has led to high production costs. If you want to expand market share, it is urgent to optimize the synthesis route and reduce costs. On the other hand, regulations and policies are increasingly strict in the supervision of pharmaceutical and pesticide products. (2R) -1- (2,4-dichlorophenyl) -2- ((tetrahydro-2H-pyran-2-yl) oxy) propyl-1-ol as a raw material needs to meet many stringent quality and safety standards, which also brings certain pressure to production enterprises.

Overall, the (2R) -1- (2,4-dichlorophenyl) -2- ((tetrahydro-2H-pyran-2-yl) oxy) propyl-1-ol market has broad prospects, but it also needs to deal with many challenges such as costs and regulations in order to stand out in the market competition.