2 6 Difluorobenzenesulfonyl Chloride
Fluorine Difluoride Fluorobenzene Fluorobenzyl Trifluorotoluene
2,6-difluorobenzenesulfonyl chloride
Chemical Formula C6H3ClF2O2S
Molar Mass 226.603 g/mol
Appearance Colorless to light yellow liquid
Boiling Point 236 - 238 °C
Density 1.569 g/cm³
Solubility In Water Reacts with water
Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform
Flash Point 100.2 °C
Vapor Pressure Low at room temperature
Acidity Sulfonyl chloride group is acidic in reaction
Reactivity Reactive towards nucleophiles
Chemical Formula C6H3ClF2O2S
Molecular Weight 226.60
Appearance Typically a colorless to pale yellow liquid
Boiling Point Data varies, around 230 - 240 °C under normal pressure
Density Approximately 1.6 - 1.7 g/cm³
Solubility Soluble in many organic solvents like dichloromethane, chloroform
Vapor Pressure Low vapor pressure at room temperature
Stability Reactive, especially with water and nucleophiles, decomposes on contact with moisture
FAQ

What are the main uses of 2,6-difluorobenzenesulfonyl chloride?

2% sodium 2C6-diethylaminofluorescein sulfonate, its main uses are as follows:

This substance is often used as a fluorescent indicator in many chemical analysis and detection fields. In titration analysis, it can keenly indicate the end point of the reaction. Because of its unique fluorescence properties, when the chemical environment changes, such as the pH of the solution, it will show significant fluorescence intensity or color changes, allowing analysts to accurately determine whether the reaction has reached the end point. For example, in some precipitation titration or acid-base titration experiments, it can clearly indicate the reaction process and help the experimenter obtain accurate analysis results.

It also plays a key role in the field of biomedical research. It can be used to label biomacromolecules, such as proteins, nucleic acids, etc. Through labeling, researchers can track the activity trajectories of these biomacromolecules in organisms with the help of fluorescence microscopy and other equipment, and understand their distribution, metabolic processes, and mutual mechanisms. This is of great significance for in-depth exploration of physiological and pathological processes in organisms, helping to reveal the pathogenesis of diseases, and providing a key basis for the development of targeted therapeutic drugs and means.

In terms of environmental monitoring, it can be used to detect specific substances in environmental samples such as water and soil. Due to the specific fluorescence response to certain substances, the presence and content of target substances can be quickly and sensitively detected, which is of indispensable value for timely detection of environmental pollution conditions and assessment of environmental quality, and helps relevant departments to formulate effective environmental protection and governance strategies. With its unique fluorescent properties, sodium 2,6-diethylaminofluorescein sulfonate has significant applications in many important fields such as chemical analysis, biomedical research, and environmental monitoring, which has greatly promoted the development of related scientific research and practical applications.

What are the physical properties of 2,6-difluorobenzenesulfonyl chloride?

2% 2C6 -diethylaniline hydrochloride is an organic compound. Its physical properties are many, as detailed below:
1. ** Appearance properties **: Usually in the state of white to light yellow crystalline powder. This color and morphology are used in many chemical reactions and industrial applications for its distinctive appearance identification, easy to observe and identify.
2. ** Solubility **: Soluble in water, can dissociate the corresponding ions in water, and participate in various reactions in aqueous solutions. And easily soluble in organic solvents such as alcohols and ethers. Such solubility makes it a good reactant or intermediate in the field of organic synthesis, with the help of different solvents to achieve its dispersion and reaction.
3. ** Melting point **: has a specific melting point. Accurate melting point data is of great significance for its purity identification. In actual production and scientific research, melting point determination is often used as one of the important means to judge its purity. If the melting point deviates from the standard value, it often indicates that there is a problem with its purity.
4. ** Stability **: Under conventional conditions, it has certain stability. When encountering specific chemical substances such as strong oxidants, strong acids, and strong bases, chemical reactions may occur, causing changes in their structure and properties. When storing and using, this characteristic must be fully considered to avoid contact with incompatible substances to ensure its chemical stability.
5. ** Odor **: or has a weak special odor. Although odor is not a key property, odor factors need to be carefully considered in some application scenarios that are sensitive to odor, such as food, flavors, and other fields.

Is the chemical properties of 2,6-difluorobenzenesulfonyl chloride stable?

2% 2C6-diethylaniline sulfonic acid is a chemical compound, and its chemical phase is determined.

In this compound, the sulfonic acid radical is highly charged, showing good water solubility, which can effectively reduce the surface resistance, and is useful in the surface activity domain. Its qualitative origin comes from the characteristics of molecules. Benzene is aromatic, and the distribution of the sub-cloud is uniform, forming a common system, which can resist the externalization and reduce the anti-activity. Diethyl amine is used in benzene, which provides the sub-group, which can increase the density of the sub-cloud of benzene, and determine the benzene in one step. The sulfonic acid group has a certain anti-activity, but the sulfonic acid form can reduce its activity. Under normal conditions, it is not easy to quickly react to normal substances such as acids, sulfates, oxides, etc.

However, if it is exposed to an acid, sulfonic acid, or oxidized, or oxidized environment, it is characterized or affected. In the acidic environment, the sulfonic acid group is reactive or the sulfonic acid is reactive; in the low-temperature case, the diethyl amine group may be attacked. High-degree oxidation can break the benzene, or make the sulfonic acid group original. However, in the general environment where it is often, often, and specialized, the 2% 2C6-diethylaniline sulfonic acid is determined.

What are the precautions in the preparation of 2,6-difluorobenzenesulfonyl chloride?

2% 2C6-diethylaniline hydrochloride is a commonly used substance in chemical preparation. When preparing, the following things should be paid attention to:

First, the purity of the raw materials is crucial. The 2% 2C6-diethylaniline and hydrochloric acid used must be of considerable purity. Impurities are present in the raw materials, which is likely to cause side reactions to occur, which will damage the purity of the product and reduce the yield. Therefore, when purchasing raw materials, choose a reputable supplier, and after receiving the materials, test their purity in detail.

Second, the temperature and time of the reaction must be precisely controlled. This preparation reaction is quite sensitive to temperature. If the temperature is too high, or the reaction is too violent, the side reactions will increase; if the temperature is too low, the reaction rate will be slow, the time will be long, or the reaction will be incomplete. Therefore, during the reaction process, when the temperature is closely monitored by thermometers and other instruments, the temperature will be kept within the appropriate range according to the reaction characteristics and past experience. Similarly, the reaction time should not be underestimated. If the time is too short, the reaction will not be completed; if the time is too long, or unnecessary side reactions will occur, it will be unfavorable to the product.

Third, the amount of hydrochloric acid needs to be carefully considered. As one of the reactants, the amount of hydrochloric acid directly affects the reaction process and product generation. If the dosage is too small, 2% 2C6-diethylaniline may not be fully reacted; if the dosage is too large, it will not only increase the cost, but also cause trouble to the subsequent product separation and purification. Therefore, when the manager calculates and combines the experimental exploration to determine the appropriate amount of hydrochloric acid.

Fourth, the separation and purification of the product is also a key link. After the reaction is completed, the resulting mixture may contain unreacted raw materials, by-products and solvents, etc., and must be separated and purified by suitable methods. Common methods include distillation, extraction, recrystallization, etc. The choice of which method depends on the physical and chemical properties of the product and impurities, and strives to obtain high-purity 2% 2C6-diethylaniline hydrochloride.

Fifth, safety protection must not be ignored. During the preparation process, 2% 2C6-diethylaniline and hydrochloric acid are both dangerous. 2% 2C6-diethylaniline may be toxic and irritating, and hydrochloric acid is corrosive. The operator is in front of suitable protective equipment, such as protective glasses, gloves, protective clothing, etc., and operates in a well-ventilated environment to prevent the inhalation of harmful gases and ensure personal safety and environmental safety.

What are the common synthesis methods of 2,6-difluorobenzenesulfonyl chloride?

The common synthesis methods of 2% 2C6-diethylaniline hydrochloride are as follows:

First, 2% 2C6-diethylaniline is used as the starting material to react with hydrochloric acid. This reaction is quite direct. 2% 2C6-diethylaniline is placed in a suitable reaction vessel and hydrochloric acid is slowly added dropwise. During the process, attention should be paid to the control of the reaction temperature. Generally speaking, the reaction can occur smoothly at room temperature, but in order to make the reaction more complete, it is usually heated moderately. After the reaction is completed, 2% 2C6-diethylaniline hydrochloride can be obtained by cooling and crystallization. The chemical reaction equation is roughly as follows: C H N + HCl → C H NCl.

Second, 2% 2C6-diethylaniline can be pretreated first, such as through a specific catalyst, to enhance its reactivity. Then, in the presence of an organic solvent, react with hydrogen chloride gas. Selecting a suitable organic solvent, such as ethanol, ether, etc., can promote the uniform progress of the reaction and improve the purity of the product. Hydrogen chloride gas is slowly introduced into the organic solvent containing pretreated 2% 2C6-diethylaniline. After a period of reaction, the organic solvent is removed by distillation, and then purified by recrystallization to obtain a pure 2% 2C6-diethylaniline hydrochloride.

Furthermore, 2% 2C6-diethylaniline is prepared by a series of reactions with related halogenated hydrocarbons and amine compounds, and then reacts with hydrochloric acid to form the target product. First, the halogenated hydrocarbons and amines undergo nucleophilic substitution under basic conditions to generate an intermediate of 2% 2C6-diethylaniline. After separation and purification, they react with hydrochloric acid to form hydrochloride. Although this method is a little complicated, it is more flexible for the selection of raw materials, and in some cases, it can effectively improve the yield and purity of the product.

There are many methods for synthesizing 2% 2C6-diethylaniline hydrochloride. In practical application, the most suitable synthesis path should be selected according to the availability of raw materials, cost, product purity requirements and many other factors.