What are the main uses of 2- (2,5-difluorophenyl) pyrrolidine?

(2,5-diethylamino) acetophenone, although there is no specific chemical compound in the era covered by Tiangong Kaiwu, its use can be speculated as follows from ancient ancient sayings:

This (2,5-diethylamino) acetophenone may have its use in medicine. Ancient healers often searched for various substances to make good medicines and treat people's diseases. If this substance has strange pharmacology, it may regulate qi and blood and relieve pain. Because of its unique chemical structure, it may interact with the meridians and qi and blood of the human body, so that those who are congested can pass, and those who lose money can make up for it.

In the way of dyes, it may also be useful. In the ancient dyeing workshop, in order to make the color fresh and durable, various materials are often studied. (2,5-diethylamino) acetophenone, if it has special fineness properties, may make the fabric dye a different color, add the beauty of clothing, and increase the color of life.

Furthermore, when craftsmen make exquisite utensils, it may be used as an auxiliary. For example, lacquer ware, this material may make the paint more tough and shiny than before; for metal forging, it may help to improve the properties of metals and make utensils more durable.

Although this item is not contained in "Tiangong Kaiwu", it is based on the heart of seeking novelty and kindness in various industries in ancient times. If it exists, it must be used in medicine, dyeing and weaving, and manufacturing industries to find its own great use and add well-being to people's livelihood.

What are the physical properties of 2- (2,5-difluorophenyl) pyrrolidine?

2 - (2,5 - diethylamino) acetophenone, is a kind of organic compound. Its physical properties are as follows:

Looking at its properties, it is usually a colorless to light yellow oily liquid, which takes on this form at room temperature and pressure. This substance has a specific odor, but its odor is not pungent and unpleasant, it is a special odor that organic compounds often have.

On solubility, 2 - (2,5 - diethylamino) acetophenone is soluble in many organic solvents, such as ethanol, ether, chloroform, etc. This is due to the molecular structure of the compound, and the force between the molecules of the organic solvent is suitable, so it can be well miscible. In ethanol, the two molecules interact to form a uniform solution system.

As for the melting point and boiling point, the melting point is about -25 ° C, and the boiling point is 165-168 ° C/1.6kPa. The lower melting point means that it is easier to change from solid to liquid at room temperature; the boiling point indicates that under specific pressure conditions, the corresponding temperature needs to be reached to change from liquid to gas.

In terms of density, it is about 1.01g/cm ³. This density value makes it coexist with common liquids such as water, and it will show a specific distribution state due to density differences. Because the density of water is about 1g/cm ³, when 2- (2,5-diethylamino) acetophenone is mixed with water, it will be distributed according to the volume and density relationship between the two.

In addition, 2- (2,5-diethylamino) acetophenone has a certain volatility. Although the volatility is not extremely strong, in an exposed environment, some substances will evaporate into the air over time. And because it is an organic compound, flammable, in case of open fire, hot topic and other conditions, there is a risk of combustion, use and storage should pay special attention to fire safety.

What are the synthesis methods of 2- (2,5-difluorophenyl) pyrrolidine?

To prepare 2 - (2,5 - diethylphenyl) acetophenone, there are many ways to synthesize it, the following are common methods:

** Foucault acylation reaction **:
This is an important method for constructing this compound. Acetophenone is used as a substrate and Foucault acylation reaction with 2,5 - diethylbenzene is catalyzed by Lewis acids such as anhydrous aluminum trichloride.
The reaction mechanism is that Lewis acid interacts with acylating reagents to generate acyl positive ions. This positive ion has strong electrophilicity and will attack the benzene ring of 2,5-diethylbenzene, and an electrophilic substitution reaction will occur, and then the target product 2 - (2,5-diethylphenyl) acetophenone will be generated. This reaction condition requires an anhydrous environment, because water will inactivate Lewis acid, which affects the reaction progress. And the reaction temperature, the proportion of reactants and other factors have an impact on the yield and purity of the product. Usually, the appropriate reaction temperature is between 0 ° C and room temperature, and the proportion of reactants needs to be optimized according to specific experiments.

** Grignard reagent method **:
First prepare 2,5-diethylphenyl Grignard reagent, which can be obtained by reacting 2,5-diethylbromobenzene with magnesium chips in anhydrous ether or tetrahydrofuran. Then, the Grignard reagent is added to the carbonyl group of acetophenone, hydrolyzed to produce 2- (2,5-diethylphenyl) phenylethanol, and then oxidized, such as using chromium trioxide-pyridine and other oxidants, to oxidize the alcohol to the target product acetophenone. There are many steps in this route, but the reaction selectivity is better in each step. When preparing Grignard reagents, it is necessary to be strictly anhydrous and oxygen-free. Because Grignard reagents are extremely active, they will react rapidly in contact with water or oxygen and fail. The conditions of the hydrolysis step also need to be precisely controlled so as not to affect the formation of products.

* Palladium Catalytic Coupling Reaction **:
If a suitable halogenated acetophenone and 2,5-diethylphenylboronic acid are used as raw materials, under the catalysis of palladium catalysts such as tetra (triphenylphosphine) palladium, the coupling reaction occurs in the presence of bases, and the target product can be obtained. This reaction has the advantages of high atomic economy and mild conditions. In the reaction, the activity and stability of palladium catalysts are crucial, and the type and dosage of bases will also And the choice of raw material halogenated acetophenone and 2,5-diethylphenylboronic acid needs to consider its reactivity and convenience of source.

What is the price range of 2- (2,5-difluorophenyl) pyrrolidine in the market?

Today, there are two (2,5 -diethylphenyl) phenylacetylene dragons. The price range in the market is of concern to everyone. However, if you want to clarify its price, you should carefully consider many reasons.

Looking at this dragon, the quality of its raw materials has a lot to do with the source. If the raw materials are rare and difficult to harvest, or shipped from remote places, the price will be high. On the contrary, if the raw materials are ordinary and easy to produce, the price may be slightly flat.

The art of its production is also the key. If it is carefully crafted and the process is complicated, the craftsman's labor cost will be high, and the price of the finished product will be high. If the production is slightly simpler, although it can be delivered quickly, the quality may be inferior, and the price should also be reduced.

The supply and demand of the city, especially its price. If there are many people who want it, and this thing is few, like the rain of dry years, the price will skyrocket. If the supply exceeds the demand, it will be like the grass of the autumn field, and the price will tend to fall.

The fashion of the world and the situation of the time can affect its price. Fashion trends, this thing is pursued by the world, and the price is high; the current situation is turbulent, business is blocked, and the price may fluctuate.

To sum up, the price of di (2,5-diethylphenyl) phenylacetylene dragon in the market may vary depending on raw materials, processes, supply and demand and current trends. Roughly speaking, if the raw materials are common, the process is simple, and the supply is more and less, the price may be in the hundreds; if the raw materials are thin, the process is refined, and the demand is more and less, the price may be more than a thousand gold. It is difficult to determine the exact number, but it depends on the changes in the situation.

What is the safety of 2- (2,5-difluorophenyl) pyrrolidine?

2 - (2,5 -diethylamino) acetophenone, its chemical structure contains specific functional groups and chemical structures, so its safety needs to be carefully examined from many aspects.

From the perspective of chemical properties, this substance is an organic compound with certain chemical activity. Under normal storage and use conditions, its stability is still acceptable. However, in case of high temperature, open flame or strong oxidant, it is very likely to cause violent chemical reactions, such as dangerous conditions such as combustion or even explosion. Therefore, when storing, it must be kept away from heat sources, fire sources and strong oxidants, and placed in a cool and well-ventilated place to prevent accidents.

At the level of toxicity, this substance has a certain potential harm to organisms. Experimental studies have found that if it comes into direct contact with the skin or causes skin irritation, symptoms such as redness, swelling and itching will occur; if it is not accidentally entered into the eyes, it will cause serious irritation to the eyes and damage the eye tissue. Long-term inhalation of its tiny particles or vapors volatilized in the air may also cause irritation to the respiratory tract, which in turn can cause respiratory diseases such as cough and asthma. In addition, the substance may go through a series of metabolic processes in the body, generating some metabolites, and the toxicity of these products should not be underestimated.

In terms of environmental impact, if 2 - (2,5 - diethylamino) acetophenone is discharged into the environment without proper treatment, its degradation process in the environment is relatively slow due to its chemical structure characteristics. Its residue in soil and water bodies will cause disturbance to soil ecosystems and aquatic ecosystems. It may affect the normal activities of microorganisms in soil and change the physical and chemical properties of soil; in water bodies, it will have toxic effects on aquatic organisms, destroy the living environment of aquatic organisms, and affect the ecological balance.

In summary, 2 - (2,5 - diethylamino) acetophenone must be used, stored, and disposed of in strict accordance with relevant safety regulations and operating procedures to ensure the safety of personnel and the environment from harm.