1-Propanesulfonamide, N- [3- [ (5-bromo-1H-pyrrolo [2,3-b] pyridin-3-yl) carbonyl] -2,4-difluorophenyl] - What is the chemical structure?

1-Propanesulfonamide, N- [3- [ (5-bromo-1H-pyrrolido [2,3-b] pyridine-3-yl) carbonyl] -2,4-difluorophenyl] -, the chemical structure of this compound is quite complex. According to its naming, it can be analyzed step by step.

"1-propanesulfonamide" is the basic skeleton of this compound, indicating that the structure contains propyl and sulfonamide groups. Propyl is a straight-chain alkyl group containing three carbon atoms, while sulfonic acid amide group is composed of sulfonyl group (-SO 2O -) connected with amino group (-NH 2O).

"N - [3- [ (5-bromo-1H-pyrrolido [2,3-b] pyridine-3-yl) carbonyl] -2,4-difluorophenyl] -" part, revealing that there is a complex substituent connected to the nitrogen atom. This substituent has a carbonyl-containing structure at the 3-position of the phenyl group as the core, and the other end of the carbonyl group is connected with 5-bromo-1H-pyrrolio [2,3-b] pyridine-3-group. Among them, pyrrolio [2,3-b] pyridine is a fused heterocyclic structure, which is formed by fusing the pyrrole ring with the pyridine ring. 5-bromo means that there is a bromine atom substituted at the 5-position of the fused heterocyclic ring. At the same time, the 2,4-positions of the phenyl group are respectively replaced by fluorine atoms.

In summary, the chemical structure of this compound is composed of a propane sulfonate amide skeleton and a complex substituent, and the structure of each part is combined with each other, giving the compound unique chemical properties.

1-Propanesulfonamide, N- [3- [ (5-bromo-1H-pyrrolo [2,3-b] pyridin-3-yl) carbonyl] -2,4-difluorophenyl] - What are the physical properties?

1-Propanesulfonamide, N- [3- [ (5-bromo-1H-pyrrolido [2,3-b] pyridine-3-yl) carbonyl] -2,4-difluorophenyl] This compound has many physical properties. Its appearance is often white to white solid, which is easy to observe and identify in general environment. In terms of solubility, it has a certain solubility in organic solvents such as dichloromethane, N, N-dimethylformamide, which can be used to select suitable solvents in related chemical operations to assist in the reaction or to achieve separation and purification.

The melting point of this compound is in a specific range. This value is of great significance for the study of its state change under heating and other conditions, and can provide a key reference for chemical reactions or material treatment involving temperature control. Its stability is relatively good in normal temperature and pressure environments, but when exposed to strong acids, strong bases or specific strong oxidizing agents, it is easy to cause structural changes due to chemical reactions, which requires attention to environmental conditions and avoidance of contact with related hazardous chemicals during storage and use. Its density and other physical parameters are indispensable for the measurement, ratio of materials in chemical production and the design of reaction systems, and help to accurately control the reaction process and product quality.

What is the main use of 1-Propanesulfonamide, N- [3- [ (5-bromo-1H-pyrrolo [2,3-b] pyridin-3-yl) carbonyl] -2,4-difluorophenyl] -?

1 - Propanesulfonamide, N - [3 - [ (5 - bromo - 1H - pyrrolo [2,3 - b] pyridin - 3 - yl) carbonyl] - 2,4 - difluorophenyl] - This compound is an important intermediate in organic synthesis and has a key use in the field of medicinal chemistry.

In the process of drug research and development, it is often the key building block for building novel drug molecules. When creating antimalarial drugs, based on this, a specific chemical structure can be carefully built, and compounds with high antimalarial activity are expected to be obtained through subtle modification and modification. Due to its unique chemical structure, it can precisely fit with specific targets in Plasmodium, such as enzyme activity check points or protein binding domains, by blocking key metabolic pathways or physiological processes of Plasmodium, to inhibit or even kill Plasmodium.

In the field of anti-cancer drug development, it also shows considerable potential. It can be used as a core structural unit to construct drugs with highly selective killing effect on cancer cells. By specifically binding to abnormally expressed proteins or receptors in cancer cells, it interferes with malignant biological behaviors such as cancer cell proliferation, invasion and metastasis, providing a new opportunity and path to overcome cancer problems.

In the field of pesticide chemistry, this compound is also useful. New pesticides with high efficiency, low toxicity and environmental friendliness can be developed through rational design and modification. It can specifically act on the nervous system, respiratory system and other key physiological systems of pests, precisely attack pests, while reducing the adverse effects on non-target organisms and the environment, and contribute to the sustainable development of agriculture.

In summary, 1 - Propanesulfonamide, N - [3 - [ (5 - bromo - 1H - pyrrolo [2,3 - b] pyridin - 3 - yl) carbonyl] - 2,4 - difluorophenyl] - plays a pivotal role in the field of pharmaceutical and pesticide research and development, and contributes potential to the progress of human health and agricultural production.

1-Propanesulfonamide, N- [3- [ (5-bromo-1H-pyrrolo [2,3-b] pyridin-3-yl) carbonyl] -2,4-difluorophenyl] - What are the synthesis methods?

To prepare 1-propanesulfonamide, N- [3- [ (5-bromo-1H-pyrrolido [2,3-b] pyridine-3-yl) carbonyl] -2,4-difluorophenyl], the method is as follows:
starting material, 5-bromo-1H-pyrrolido [2,3-b] pyridine-3-carboxylic acid and 2,4-difluoroaniline are selected to condense the two. At the time of condensation, the condensation agent can be selected, such as dicyclohexyl carbodiimide (DCC) or 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride (EDC · HCl), and the catalyst can also be used, such as 4-dimethylaminopyridine (DMAP), in suitable solvents, such as dichloromethane, N, N-dimethylformamide (DMF), when temperature is controlled, N - (5-bromo-1H-pyrrolido [2,3-b] pyridine-3-yl) -2,4-difluorobenzamide can be obtained. Then, N- (5-bromo-1H-pyrrolido [2,3-b] pyridine-3-yl) -2,4-difluorobenzamide was taken and reacted with 1-propanesulfonyl chloride. In this step, a base is used as an acid binding agent, such as triethylamine, pyridine, etc., in a solvent, such as dichloromethane and toluene, and reacts at a certain temperature and time to obtain the target product 1-propanesulfonamide, N- [3- [ (5-bromo-1H-pyrrolido [2,3-b] pyridine-3-yl) carbonyl] -2,4-difluorophenyl].
Or, first react 2,4-difluorobenzoic acid with 1-propanesulfonamide to obtain 2,4-difluoro-N- (propane-1-sulfonyl) benzamide. Then the activated esters of 5-bromo-1H-pyrrolido [2,3-b] pyridine-3-carboxylic acids, such as acid chloride, can also be reacted with 2,4-difluoro-N- (propane-1-sulfonyl) benzamide. All these methods need to be selected according to factors such as raw materials, equipment, and cost.

1-Propanesulfonamide, N- [3- [ (5-bromo-1H-pyrrolo [2,3-b] pyridin-3-yl) carbonyl] -2,4-difluorophenyl] - What are the precautions in storage and transportation?

1-Propanesulfonate amide, N- [3- [ (5-bromo-1H-pyrrolido [2,3-b] pyridine-3-yl) carbonyl] -2,4-difluorophenyl] This material, when storing and transporting, many matters need to be paid attention to.

First words storage, this is a crucial move. Due to its chemical properties, it should be placed in a dry and cool place. If it is in a humid environment, it is easy to interact with water vapor, or cause deterioration, affecting its chemical structure and properties. And the temperature should not be too high, high temperature or chemical reaction will damage its quality. Furthermore, the storage place should be kept away from fire sources and oxidants, as it may be flammable or react violently with oxidants, which endangers safety. It must be stored in a sealed container to prevent oxidation or absorption of impurities in the air due to contact with the air.

As for transportation, it should not be underestimated. Before transportation, make sure that the packaging is intact to prevent leakage. Choose suitable transportation means, considering its chemical properties. If it is dangerous goods, it should be transported in accordance with relevant regulations. During transportation, avoid bumps and vibrations to prevent package damage. And the transportation environment should also meet the storage requirements, keep it dry and cool, and do not mix with contraband materials to avoid accidents. Only in this way can the quality and safety of this chemical be guaranteed when storing and transporting it.