1-Propanesulfonamide, N- [3- [[5-bromo-1- (2,6-dichlorobenzoyl) -1H-pyrrolo [2,3-b] pyridin-3-yl] carbonyl] -2,4-difluorophenyl] - What is the chemical structure?

This is to explore the chemical structure of 1-propanesulfonamide, N- [3- [[5-bromo-1- (2,6-dichlorobenzoyl) -1H-pyrrolio [2,3-b] pyridine-3-yl] carbonyl] -2,4-difluorophenyl]. Looking at its naming, it can be explained step by step.

"1-propanesulfonamide", it can be known that its basic structure is propanesulfonamide, propyl is connected to the sulfonyl group, and the nitrogen atom of the sulfonyl group is then connected to the other groups. " N - [3- [[5-bromo-1- (2,6-dichlorobenzoyl) -1H-pyrrolido [2,3-b] pyridine-3-yl] carbonyl] -2,4-difluorophenyl] ", this part indicates that the nitrogen atom is linked to complex groups.

From the inside out, "5-bromo-1- (2,6-dichlorobenzoyl) -1H-pyrrolido [2,3-b] pyridine-3-yl", this is a fused ring structure, pyrrolido-pyridine ring system, bromine atom at the 5th position, 2,6-dichlorobenzoyl at the 1st position, and connected to other parts through the 3rd position. " The carbonyl group is connected to the fused ring at the 3rd position, and then connected to the "3- [... carbonyl] -2,4-difluorophenyl group", that is, the benzene ring is connected to the above carbonyl group at the 3rd position, and there are fluorine atoms at the 2nd and 4th positions. In this way, the structure of this compound is clearly presented. Starting from propanesulfonamide, complex aryl groups are connected by nitrogen atoms. The aryl group contains specific substituents and fused ring structures, and each part is connected in an orderly manner according to the naming rules to construct a unique chemical structure.

1-Propanesulfonamide, N- [3- [[5-bromo-1- (2,6-dichlorobenzoyl) -1H-pyrrolo [2,3-b] pyridin-3-yl] carbonyl] -2,4-difluorophenyl] - What are the physical properties?

Amine 1-propanesulfonate, N- [3- [[5-bromo-1- (2,6-dichlorobenzoyl) -1H-pyrrolido [2,3-b] pyridine-3-yl] carbonyl] -2,4-difluorophenyl], this substance has many physical properties. Its appearance is often a specific state, or a crystalline powder, color or white, or microstrip color, which varies depending on the preparation process and purity.

When it comes to solubility, its performance varies in organic solvents. Common organic solvents such as dichloromethane, N, N-dimethylformamide are soluble in them, but in water, the solubility is poor, and the hydrophilicity is weak due to the characteristics of the groups contained in the molecular structure. The melting point of

is also an important physical property. After experimental determination, the melting point of the substance is in a specific range, but the specific value is affected by the test method and the purity of the sample. The determination of the melting point is often determined by thermal analysis techniques, such as differential scanning calorimetry, which can be accurately obtained. In terms of the boiling point of

, due to the complex structure of the compound, it is difficult to determine the exact boiling point at high temperature or decomposition. However, by theoretical calculation and comparison with similar structural compounds, it can be known that its boiling point is quite high, which needs to be studied under specific conditions. The value of

density is related to the relationship between its mass and volume. Although the relevant data are rarely reported accurately, according to its molecular structure and elemental composition, it can be inferred that its density is slightly higher than that of common organic compounds. This is due to the presence of heavy atoms such as bromine and chlorine in the molecule, which increases the weight per unit volume.

In addition, the compound has certain stability. Under normal temperature and pressure, if properly stored, it can maintain the chemical structure unchanged for a certain period of time. In case of extreme conditions such as strong acid, strong base or high temperature, its structure may change, causing physical properties to change.

What are the common uses of 1-Propanesulfonamide, N- [3- [[5-bromo-1- (2,6-dichlorobenzoyl) -1H-pyrrolo [2,3-b] pyridin-3-yl] carbonyl] -2,4-difluorophenyl] -?

This is the name of the chemical substance, named 1-propanesulfonamide, N- [3- [[5-bromo-1- (2,6-dichlorobenzoyl) -1H-pyrrolio [2,3-b] pyridine-3-yl] carbonyl] -2,4-difluorophenyl] -. However, common uses, such new chemicals are rarely recorded in ancient literature, and today's chemical research and industrial production may involve pharmaceutical research and development, organic synthesis and other fields. In pharmaceutical research and development, or as a new active ingredient, through a series of experiments to explore its pharmacological activity and safety, it is expected to become a new drug; in organic synthesis, or as a key intermediate, through chemical reactions, to construct complex organic molecules. Although there are no ancient books, today's chemical methods have many uses and are essential for scientific research and industry.

1-Propanesulfonamide, N- [3- [[5-bromo-1- (2,6-dichlorobenzoyl) -1H-pyrrolo [2,3-b] pyridin-3-yl] carbonyl] -2,4-difluorophenyl] - What are the synthesis methods?

To prepare 1-propanesulfonamide, N- [3- [[5-bromo-1- (2,6-dichlorobenzoyl) -1H-pyrrolido [2,3-b] pyridine-3-yl] carbonyl] -2,4-difluorophenyl], there are many methods. The following are common synthesis routes.

First, the key intermediate can be constructed by multi-step reaction. First, take a suitable pyridine derivative, brominate the pyridine ring at a specific position under suitable reaction conditions with a specific halogenating agent, such as bromine, to obtain a 5-bromopyridine intermediate. This step requires controlling the reaction temperature, time and reagent dosage to prevent side reactions from occurring.

Next, 2,6-dichlorobenzoic acid is reacted with an appropriate activator, such as oxalyl chloride, to obtain 2,6-dichlorobenzoyl chloride. This acid chloride is then acylated with 5-bromo-pyridine intermediates under the catalysis of bases, such as triethylamine, to obtain 5-bromo-1 - (2,6-dichlorobenzoyl) -1H-pyrrolido [2,3-b] pyridine-3-carbonyl intermediates. < Br >
Another benzene derivative containing difluoride is introduced into the carbonyl group through a specific reaction, and then reacts with the above-mentioned pyridine-containing carbonyl intermediate in the presence of a suitable condensation agent, such as dicyclohexylcarbodiimide (DCC) and catalyst 4-dimethylaminopyridine (DMAP), to connect the two.

Finally, the obtained product is reacted with 1-propanesulfonamide under alkali catalysis, heating and other conditions. After post-treatment, such as extraction, column chromatography, etc., the target product 1-propanesulfonamide is purified, N - [3 - [5-bromo-1 - (2,6-dichlorobenzoyl) -1H-pyrrolido [2,3-b] pyridine-3-yl] carbonyl] -2,4-difluorophenyl]. < Br >
Each step of the reaction needs to be based on the characteristics of the reactants, the reaction mechanism, and the precise control of the reaction conditions to achieve high yield and purity, and finally the synthesis of this compound.

1-Propanesulfonamide, N- [3- [[5-bromo-1- (2,6-dichlorobenzoyl) -1H-pyrrolo [2,3-b] pyridin-3-yl] carbonyl] -2,4-difluorophenyl] - What is the market availability?

In today's world, inquire about the supply situation of 1 - Propanesulfonamide, N - [3 - [[5 - bromo - 1 - (2,6 - dichlorobenzoyl) -1H - pyrrolo [2,3 - b] pyridin - 3 - yl] carbonyl] -2,4 - difluorophenyl] - in the market. This is a specific compound in the field of fine chemistry, with a complex structure, containing halogen atoms such as bromine, chlorine, and fluorine and a variety of specific groups.

Intermarket supply is often involved in chemical raw material suppliers and scientific research reagent suppliers. In the scientific research reagent market, it may be supplied in small packages to meet the needs of laboratory research and development and analysis. Such supplies are mostly high-purity products to ensure that the experimental results are accurate, but the quantity is small and the price is high.

In the chemical raw material market, if this compound is an intermediate for large-scale production, there may be a large-scale supply. However, its production is constrained by many factors, such as the availability of raw materials, the difficulty of synthesis processes, and environmental regulations. If raw materials are scarce or expensive, the supply will be limited. If the synthesis process is complicated and the cost rises, it will also affect the scale of supply. Stringent environmental regulations require compliance in the production process, or some manufacturers may reduce production or even stop production.

In addition, market demand also affects the supply. If research and development in related fields is active, the demand for drugs and materials with this structure increases sharply, and the supply may be tight; conversely, if the demand is low, the supply may be surplus. Therefore, the supply situation of this compound in the market is affected by a variety of factors, or varies from time to time, making it difficult to generalize.