What is the chemical structure of 1- [ (difluoromethyl) sulfonyl] -3- (4,6-dimethoxy-1,3,5-triazin-2-yl) -7-fluoro-1H-indol-2-ol

Eh! The chemical structure of Ximing 1- [ (difluoromethyl) sulfonyl] -3- (4,6-dimethoxy-1,3,5-triazine-2-yl) -7-fluoro-1H-indole-2-ol, let me tell you in detail.

The structure of this compound is based on the indole ring. The indole ring is a nitrogen-containing aromatic heterocycle, which is common in many natural products and pharmaceutical active ingredients. Above the first position, there is a (difluoromethyl) sulfonyl group, which has unique electronic effects and steric resistance. ( In the case of difluoromethyl), two fluorine atoms are attached to the methyl group, and the fluorine atom has high electronegativity, which can change the distribution of the electron cloud; the sulfonyl group (-SO 2O -) further affects its chemical properties and reactivity.

3-position is connected with 4,6-dimethoxy-1,3,5-triazine-2-group. The triazine ring is also an aromatic heterocycle, with three nitrogen atoms distributed in each phase, and the methoxy group (-OCH 🥰) at positions 4 and 6 is the power supply group, which can affect the electron cloud density of the triazine ring, which in turn affects the activity of the whole molecule. The presence of fluorine atoms at positions

7 cannot be ignored. Fluorine atoms, because of their special electronic properties, can change the electron cloud distribution of the indole ring, affect the molecular lipophilicity, stability and interaction with biological targets. The hydroxy group (-OH) at the

2 position is hydrophilic and can participate in the formation of hydrogen bonds. It plays a key role in molecular solubility and interaction with biological macromolecules.

In this way, the groups are connected to different positions of the indole ring and interact with each other to form the unique chemical structure of 1- [ (difluoromethyl) sulfonyl] -3- (4,6-dimethoxy-1,3,5-triazine-2-yl) -7-fluoro-1H-indole-2-ol.

What are the physical properties of 1- [ (difluoromethyl) sulfonyl] -3- (4,6-dimethoxy-1,3,5-triazin-2-yl) -7-fluoro-1H-indol-2-ol

1-%5B%28difluoromethyl%29sulfonyl%5D-3-%284%2C6-dimethoxy-1%2C3%2C5-triazin-2-yl%29-7-fluoro-1H-indol-2-ol is an organic compound. Its physical properties are related to many external manifestations and characteristics of this compound, and have a significant impact on its behavior and application in various scenarios.

Looking at its properties, under normal temperature and pressure, this substance may be in solid form. This is closely related to its intermolecular force, which causes it to exist in a solid state under normal conditions. This solid state property makes it relatively convenient for storage and transportation, with high stability, and is not easy to flow or evaporate like liquid or gaseous substances.

In terms of melting point, this compound may have a specific melting point value. The melting point is the critical temperature at which a substance changes from a solid state to a liquid state, which is of great significance for its identification and purity judgment. If the purity of the compound is very high, its melting point should be very close to the theoretical value, and the deviation is very small; on the contrary, the mixing of impurities will reduce the melting point and widen the melting range. By measuring the melting point, the experimenter can quickly determine the purity of the compound, providing key information for subsequent experiments and applications.

In terms of solubility, it varies in different solvents. In organic solvents, such as common dichloromethane, N, N-dimethylformamide, etc., it may have a certain solubility. This is due to the principle of "similarity and miscibility". The molecular structure of the compound is similar to that of organic solvents, allowing them to interact and mix with each other. In water, its solubility may be low. Due to the poor matching between the polarity of water and the polarity of the compound molecule, the force between the water molecule and the compound molecule is weak, making it difficult to disperse the compound molecule in water. This difference in solubility is crucial in the separation, purification and solvent selection of the compound. Experimenters can choose a suitable solvent for the corresponding operation according to its solubility characteristics.

In addition, the density of the compound is also one of the important physical properties. Density reflects the mass of the substance in a unit volume. Knowing its density is crucial in operations involving mass and volume conversion. For example, when formulating a solution with a specific concentration, the required volume of the compound can be accurately measured by the density to achieve the purpose of accurate experiments.

In summary, the physical properties of 1-%5B%28difluoromethyl%29sulfonyl%5D-3-%284%2C6-dimethoxy-1%2C3%5D-3-%284%2C6-dimethoxy-1%2C3%2C5-triazin-2-yl%29-7-fluoro-1H-indol-2-ol, from properties, melting point, solubility to density, are the key elements for the study and application of this compound, helping researchers to better understand and use the compound rationally.

What is the application field of 1- [ (difluoromethyl) sulfonyl] -3- (4,6-dimethoxy-1,3,5-triazin-2-yl) -7-fluoro-1H-indol-2-ol

1-%5B%28difluoromethyl%29sulfonyl%5D-3-%284%2C6-dimethoxy-1%2C3%2C5-triazin-2-yl%29-7-fluoro-1H-indol-2-ol, this is an organic compound. Looking at the delicacy of its structure, it must have unique properties and uses.

In the field of medicine, it may have significant power. Or it can show the potential of treating diseases by its precise action on specific biological targets. With special groups contained in its structure, it may be able to combine with key proteins or enzymes in diseased cells to block abnormal physiological processes and achieve therapeutic effect. For example, targeting the proliferation signaling pathway of some tumor cells, it may be inhibited by the action of this compound, thereby controlling tumor growth.

In agriculture, it may also have extraordinary performance. Or it can be used as a new type of pesticide ingredient, with its unique chemical properties, to show the ability to effectively inhibit or kill specific pests or pathogens. And because of its novel structure, it may avoid the drawbacks of traditional pesticides that easily cause pests to develop resistance, adding a new path to agricultural pest control.

In the field of materials science, it may participate in the creation of new materials. With its special chemical structure, it may endow materials with unique physical and chemical properties, such as improving the stability and optical properties of materials. Or it can be used to prepare polymer materials with special functions, which can be used in electronics, optics and other fields.

However, this is all based on the speculation of its structural characteristics. To clarify its exact application, a lot of experiments and studies are needed. After repeated verification, its true effectiveness and application value in various fields can be determined.

What is the synthesis method of 1- [ (difluoromethyl) sulfonyl] -3- (4,6-dimethoxy-1,3,5-triazin-2-yl) -7-fluoro-1H-indol-2-ol

To prepare 1- [ (difluoromethyl) sulfonyl] -3 - (4,6 - dimethoxy - 1,3,5 - triazine - 2 - yl) -7 - fluoro - 1H - indole - 2 - alcohol, the method is as follows:
starting material, you can take the fluorine-containing indole derivative first, this derivative needs to reserve the reaction check point at a specific position, for the subsequent modification foundation. And take the difluoromethyl sulfonylation reagent, this reagent is active, and difluoromethyl sulfonyl can be introduced. The fluoroindole derivative and the difluoromethyl sulfonylation reagent are placed in a suitable reaction solvent, such as an aprotic organic solvent, such as N, N-dimethylformamide (DMF) or dichloromethane. An appropriate amount of base is added, which can help the reagent to activate and make the reaction proceed in the direction of generating the target product. Commonly used bases such as potassium carbonate, triethylamine, etc. Control the reaction temperature at a moderate temperature, or between room temperature and heated reflux, depending on the reaction process and the activity of the substrate, stir to make the reaction uniform. After a period of time, the specific position of the indole derivative can be nucleophilic substitution with the difluoromethyl sulfonylation reagent, and the difluoromethyl sulfonyl group can be successfully introduced at the indole 1 position.
Then, take 4,6-dimethoxy-1,3,5-triazine-2-halide, halogen atoms such as chlorine, bromine, etc., with good activity. The indole derivative already containing difluoromethyl sulfonyl group and 4,6-dimethoxy-1,3,5-triazine-2-halide are co-placed in a new reaction system, and a suitable solvent is still used, or DMF as before. An appropriate amount of base is also added to catalyze the reaction. When heated to a suitable temperature, the condensation reaction between the two occurs, and the triazine group is connected to the third position of the indole.
After the reaction is completed, the target product 1 - [ (difluoromethyl) sulfonyl] -3 - (4,6 - dimethoxy - 1,3,5 - triazine - 2 - yl) -7 - fluoro - 1H - indole - 2 - alcohol is separated from the reaction mixture by conventional separation and purification methods, such as column chromatography, and a suitable eluent is selected. A pure product is obtained.

1- [ (difluoromethyl) sulfonyl] -3- (4,6-dimethoxy-1,3,5-triazin-2-yl) -7-fluoro-1H-indol-2-ol

The chemical name "1- [ (difluoromethyl) sulfonyl] -3 - (4,6-dimethoxy-1,3,5-triazine-2-yl) -7-fluoro-1H-indole-2-ol" is related to its safety information. Although it is not detailed in ancient books, it can be deduced according to common sense and chemical principles.

This compound contains fluorine, sulfur and other elements. Fluoride is more active, and some or some of it may be toxic. Contact or cause skin and mucosal irritation. Sulfur-containing groups may also affect their chemical stability and reactivity. In case of specific conditions, or unstable reactions, harmful gases are released, endangering the surrounding environment and personal safety.

And such complex organic compounds are metabolized in living organisms or have unknown risks. Although it has not been conclusively experimentally concluded that their carcinogenic and teratogenic hazards, according to the usual chemical substance research, complex structural compounds may have potential biological activities, and long-term exposure, ingestion or adverse effects on the genetic materials and physiological functions of organisms.

When storing, be careful, because its chemical properties are unknown, or it is necessary to isolate fire and heat sources to prevent dangerous reactions due to heat and impact. And because it may be corrosive and irritating, the storage environment must be dry and well ventilated to ensure safety. When using, also follow strict operating procedures and prepare protective equipment, such as gloves, goggles, protective clothing, etc., to prevent contact with the human body and endanger health.