What are the main uses of 1-bromo-3,5-difluorobenzene?

1-Bromo-3,5-difluorobenzene is 1-bromo-3,5-difluorobenzene, which is widely used. In the field of medicinal chemistry, it is often used as a key intermediate. Many drug synthesis processes rely on its participation in the construction of specific chemical structures to obtain the expected pharmacological activity. For example, when synthesizing some new drugs with antibacterial and anti-inflammatory effects, 1-bromo-3,5-difluorobenzene is reacted with other compounds to shape a molecular configuration that fits the target of drug action.

In the field of materials science, it also has important functions. It can be used to prepare special polymer materials. By polymerizing with other monomers, the materials are endowed with unique properties, such as improving the thermal stability and chemical stability of the materials. In the field of optoelectronic materials, 1-bromo-3,5-difluorobenzene participates in the synthesis of materials, or has excellent optical properties. It has emerged in the fabrication of organic Light Emitting Diodes (OLEDs) and other devices to improve the luminous efficiency and stability of devices.

In addition, in the production of fine chemicals, 1-bromo-3,5-difluorobenzene is an important raw material for the synthesis of a variety of fine chemicals, such as special fragrances, additives, etc. After a series of chemical reactions, it is converted into products that meet different industrial and living needs, contributing to the development of the fine chemical industry.

What are the physical properties of 1-bromo-3,5-difluorobenzene?

1 - bromo - 3,5 - difluorobenzene is an organic compound with unique physical properties. It is usually a colorless to light yellow liquid at room temperature and pressure, with a clear appearance and can be perceived by sight and touch.

Look at its boiling point, which is about 150 - 160 ° C. The boiling point is the temperature at which a substance changes from a liquid state to a gaseous state. The boiling point of this compound is not very high, which is determined by the force between molecules. Its molecules contain bromine and fluorine atoms. Although the halogen atoms increase the polarity of the molecule slightly, the overall relative molecular mass does not reach a very high degree, so the boiling point does not reach a high range.

In terms of melting point, it is between -30 ° C and -20 ° C. The melting point is the temperature at which a substance changes from a solid state to a liquid state. The compound has a low melting point. Due to the certain symmetry of the benzene ring in the molecular structure, and the relatively uniform distribution of halogen atom substitution positions, the lattice energy is not high. In the solid state, the intermolecular bonding force is weak, and it is easy to melt when heated up.

When it comes to density, it is larger than water, about 1.8-1.9 g/cm ³. The density reflects the mass of the substance per unit volume. The compound contains bromine and fluorine atoms with relatively large atomic mass, which increases the mass per unit volume, so the density is higher than that of water. Mixing it with water will sink to the bottom of the water.

Solubility, slightly soluble in water, but soluble in common organic solvents such as ethanol, ether, dichloromethane, etc. Because it is an organic compound with certain hydrophobicity and strong hydrogen bonding between water molecules, it is difficult for this compound to form an effective interaction with water. However, organic solvents and their intermolecular forces are similar, and they can be well miscible according to the principle of similar miscibility.

In addition, 1-bromo-3,5-difluorobenzene has a certain degree of volatility, which will slowly evaporate in the air and emit a special odor. Due to its halogen-containing atoms and active chemical properties, it can participate in many organic synthesis reactions and is an important organic synthesis intermediate.

What are the synthesis methods of 1-bromo-3,5-difluorobenzene?

There are several common methods for the synthesis of 1-bromo-3,5-difluorobenzene.

First, 3,5-difluoroaniline is used as the starting material. First, it is diazotized with sodium nitrite and hydrochloric acid at low temperature. This process requires fine control of the temperature to prevent the reaction from getting out of control. The diazonium salt generated by diazotization is then reacted with cuprous bromide. After Sandmeier reaction, 1-bromo-3,5-difluorobenzene can be obtained. This method is a little complicated, but the conditions are relatively mild and the yield is acceptable.

Second, 3,5-difluorobenzoic acid is used as the starting material. It is first converted into an acyl chloride, which can be co-heated with sulfoxide chloride. The obtained acyl chloride is then reduced by Rosemond, using palladium-barium sulfate as catalyst and quinoline-sulfur as inhibitor to reduce the acyl chloride to aldehyde. The aldehyde is further reacted with brominating reagents such as phosphorus tribromide, and the target product can be obtained through series conversion. This path has many steps and requires high reaction conditions and catalysts.

Third, benzene is used as the starting material. First, the bromination reaction of benzene is carried out, and bromine and iron tribromide are used as reagents to obtain bromobenzene. Subsequently, bromobenzene is fluorinated, and a nucleophilic fluoride reagent can be used to introduce fluorine atoms under specific conditions. Although the starting material of this method is simple and easy to obtain, the bromination and fluorination steps need to be precisely regulated to ensure the selectivity and purity of the product.

All synthetic methods have their own advantages and disadvantages. In practical application, the appropriate method should be carefully selected according to factors such as raw material availability, cost, yield and purity requirements.

What are the precautions for 1-bromo-3,5-difluorobenzene during storage and transportation?

1 - bromo - 3,5 - difluorobenzene is an organic compound. When storing and transporting, be sure to pay attention to the following things:

First, when storing, find a cool, dry and well-ventilated place. This substance is more sensitive to heat and humidity. In the environment of high temperature and humidity, it may cause adverse reactions such as decomposition, which will damage the quality. Therefore, the temperature of the warehouse should be controlled within an appropriate range, and the humidity should also be kept at a low level.

Second, because of its certain chemical activity, it should be stored away from fire and heat sources, and must not be mixed with oxidants, strong bases and other substances. Oxidants may cause violent oxidation reactions, and strong bases may also react with them, endangering safety. It is necessary to strictly follow the specifications for the storage of chemical substances, and store them in zones and categories to avoid interactions.

Third, during transportation, the packaging must be tight and reliable. Appropriate packaging materials need to be selected to ensure that it does not leak under bumps, vibrations, etc. Commonly used packaging includes sealed glass bottles, sturdy wooden boxes and filled with cushioning materials; or specially designed chemical barrels.

Fourth, transport personnel should be familiar with the characteristics of the substance and emergency treatment methods. In the event of leakage, correct measures should be taken quickly to prevent the spread of hazards. If the surrounding crowd is evacuated immediately, set up warning signs, use suitable materials to absorb the leakage, and properly handle it.

Fifth, the entire storage and transportation process should strictly follow relevant regulations and standards. Whether it is the construction and maintenance of storage facilities, the selection of transportation vehicles, and the planning of travel routes, safety requirements must be met to ensure the safety of 1-bromo-3,5-difluorobenzene during storage and transportation.

What is the market price range for 1-bromo-3,5-difluorobenzene?

The market price range of 1-bromo-3,5-difluorobenzene (1-bromo-3,5-difluorobenzene) is difficult to determine. This is due to the fickle market conditions, and the price often fluctuates for many reasons.

Looking at the past market conditions, the price of this chemical may be affected by factors such as the price of raw materials, the status of supply and demand, the method of preparation, trade policy and market competition. If the raw material is easy to obtain and affordable, the production rate is high due to excellent craftsmanship, and the market demand is not booming and the supply is abundant, the price may stabilize and be low. On the contrary, if the raw material is scarce and expensive, the preparation is difficult, and the demand is strong, the price may rise.

In the chemical market, the price of such fine chemicals in the past ranged from a few hundred yuan per kilogram to a few thousand yuan. However, this is only a rough figure, and it is not an exact value. Recently, due to changes in the global chemical industry structure, there may be obstruction in the supply chain, and stricter environmental regulations, which may cause their costs to change, which in turn affects the selling price.

If you want an accurate price, you should consult chemical raw material suppliers, traders, or check recent transaction records on the chemical trading platform to get a price range that is close to the truth.