What is the chemical structure of 1- (4- ((2R, 5R) -2,5-bis (4-chloro-2-fluoro-5-nitrophenyl) pyrrolidine-1-yl) -2,6-difluorophenyl) -4- (4-fluorophenyl) piperidine?

The naming of this organic compound is complicated, and there is some confusion in the expression, so it is necessary to sort out its structural characteristics first. From the naming, it can be roughly seen that the core structure of this compound revolves around the benzene ring and related substituents.

"1- (4- ((2R, 5R) -2,5-bis (4-bromo-2-chloro-5-cyanophenyl) pentyl-1-yl) -2,6-dichlorophenyl) -4- (4-chlorophenyl) ".

The compound takes the phenyl ring as the parent body, and has a complex substituent at the 1st position. This substituent contains an amyl chain. The 2,5 position of the amyl chain has two identical substituents, which are 4-bromo-2-chloro-5-cyanophenyl; the 2,6 position of the phenyl ring is a chlorine atom; the 4 position is 4-chlorophenyl. The chemical structure of

is as follows:
is centered on the benzene ring, with an amyl chain connected at 1 position, a 4-bromo-2-chloro-5-cyanophenyl group connected at 2 and 5 positions of the amyl chain, a chlorine atom connected at 2 and 6 positions of the benzene ring, and a 4-chlorophenyl group connected at 4 positions. Among them, the chirality of the 2,5 positions of the amyl chain is the R configuration. The structure contains groups such as benzene ring, chlorine atom, bromine atom, and cyano group. The spatial arrangement and interaction of these groups determine the physical and chemical properties of the compound.

What are the physical properties of 1- (4- ((2R, 5R) -2,5-bis (4-chloro-2-fluoro-5-nitrophenyl) pyrrolidine-1-yl) -2,6-difluorophenyl) -4- (4-fluorophenyl) piperidine?

1 - (4- ((2R, 5R) -2,5 -bis (4-cyanogen-2-fluoro-5-methoxyphenyl) pyrrolidine-1-yl) -2,6-difluorophenyl) -4 - (4-fluorophenyl) and its physical properties include many aspects.

The appearance of this compound is inferred from the characteristics of common organic compounds, or it is a crystalline solid, because many organic compounds containing benzene rings and heterocycles often take this form. Its color may be colorless or white, and most organic compounds with relatively simple structures and no special conjugated chromophores are mostly of this color.

In terms of melting point, due to the presence of benzene ring, fluorine atom and pyrrolidine group in the molecule, the intermolecular forces are relatively complex. The π-π stacking between benzene rings, the weak hydrogen bond and van der Waals force generated by fluorine atoms will make the molecules bond tightly, and the expected melting point is high, which may be in the range of 150-300 ° C.

In terms of solubility, the compound contains multiple hydrophobic benzene ring structures, which have poor solubility in water, a polar solvent. In halogenated hydrocarbons such as dichloromethane and chloroform, as well as aromatic hydrocarbons such as toluene and benzene, the solubility should be better due to the principle of similar miscibility; in polar organic solvents such as ethanol and acetone, according to the molecular polarity distribution, there may be some solubility, but it is not as good as in the above non-polar or weakly polar organic solvents.

The density is due to the presence of fluorine atoms in the molecular structure. The relative atomic mass of fluorine atoms is large and the atomic radius is small, which will cause the molecules to pack tightly. The estimated density is larger than that of water, which may be in the range of 1.2-1.5 g/cm ³.

In terms of stability, the benzene ring structure is relatively stable, but the functional groups such as cyano and fluorine atoms can participate For example, the cyanide group may be hydrolyzed under acidic or alkaline conditions; in the presence of strong oxidizing agents or reducing agents, some chemical bonds in the molecule may also be destroyed. But in the conventional dark, dry, room temperature environment, it can maintain good stability.

What is the synthesis method of 1- (4- ((2R, 5R) -2,5-bis (4-chloro-2-fluoro-5-nitrophenyl) pyrrolidine-1-yl) -2,6-difluorophenyl) -4- (4-fluorophenyl) piperidine?

To prepare (1- (4- ((2R, 5R) -2,5-bis (4-fluoro-2-methoxy-5-pyrimidinyl) pyrrolidine-1-yl) -2,6-dimethoxyphenyl) -4- (4-methoxyphenyl)) and its synthesis, the following steps can be followed.

The selection of starting materials is crucial. First, take a suitable (2R, 5R) -2,5-bis (4-fluoro-2-methoxy-5-pyrimidinyl) pyrrolidine-1-yl related compound, which is an important cornerstone for building a molecular structure. < Br >
In a suitable reaction vessel, add an appropriate amount of organic solvents, such as dichloromethane, N, N-dimethylformamide, etc., which can create a stable environment for the reaction. Then add carefully measured bases, such as potassium carbonate, triethylamine, etc. The function of the base is to adjust the pH of the reaction system and promote the smooth progress of the reaction.

Add the prepared (2R, 5R) -2,5-bis (4-fluoro-2-methoxy-5-pyrimidinyl) pyrrolidine-1-yl compound to the reaction system slowly, and add the matching halogenated aromatics. The choice of halogenated aromatics should be suitable for the reaction design, such as 4-halogenated-2,6-dimethoxybenzene and 4-halogenated-4-methoxybenzene. The reaction process requires close attention to temperature control, usually maintained in a moderate temperature range, such as between room temperature and 60 ° C, which can be fine-tuned according to the specific conditions of the reaction. The reaction process can be monitored by thin-layer chromatography (TLC). When the raw material point is basically eliminated, it indicates that the reaction has reached the expected level.

After the reaction is completed, pour the reaction solution into an appropriate amount of water, extract it with an organic solvent such as ethyl acetate, and merge the organic phases after multiple extractions. The organic phase is dried with a desiccant such as anhydrous sodium sulfate to remove the moisture. Then the organic solvent is removed by distillation under reduced pressure to obtain a crude product.

The crude product needs to be further purified. Column chromatography can be used to select suitable silica gel and eluent, such as a mixture of petroleum ether and ethyl acetate, and adjust the ratio of the two according to the polarity of the product. After this purification step, the pure target product (1- (4- ((2R, 5R) -2,5-bis (4-fluoro-2-methoxy-5-pyrimidinyl) pyrrolidine-1-yl) -2,6-dimethoxyphenyl) -4- (4-methoxyphenyl)) can be obtained.

The whole synthesis process requires fine operation by the experimenter and strict control of each reaction condition to ensure the purity and yield of the product.

What are the application fields of 1- (4- ((2R, 5R) -2,5-bis (4-chloro-2-fluoro-5-nitrophenyl) pyrrolidine-1-yl) -2,6-difluorophenyl) -4- (4-fluorophenyl) piperidine?

This is (1R, 5R) -2,5-bis (4-methoxy-2-ethoxy-5-tert-butylphenyl) bicyclic [2.2.1] heptyl-2-ene-1-yl-2,6-diethoxy benzene and its application field related questions, the following answer in classical Chinese form:

(1R, 5R) -2,5-bis (4-methoxy-2-ethoxy-5-tert-butylphenyl) bicyclic [2.2.1] heptyl-2-ene-1-yl-2,6-diethoxy benzene is one of organic compounds. Its unique structure is composed of a dicycloheptene skeleton with specific substituted phenyl and ethoxy groups. < Br >
This compound can be used in the field of materials science, or can be used to prepare high-performance optical materials. Due to its special structure, it may endow the material with excellent optical properties, such as high transparency, specific refractive index, etc., it is used in the manufacture of optical lenses, optical fibers and other devices to improve their optical quality.

In the field of pharmaceutical chemistry, it also has potential applications. Its structure may be used as the core skeleton of active pharmaceutical ingredients. Through appropriate modification, or it can be combined with specific targets in vivo, it exhibits pharmacological activities such as antibacterial, anti-inflammatory, and anti-tumor, providing an opportunity for the development of new drugs.

In the field of organic synthesis, it can act as a key intermediate. With its unique functional groups and structures, it participates in a variety of organic reactions to build more complex organic molecular structures, expand the ways and methods of organic synthesis, and contribute to the development and innovation of organic chemistry.

What is the market outlook for 1- (4- ((2R, 5R) -2,5-bis (4-chloro-2-fluoro-5-nitrophenyl) pyrrolidine-1-yl) -2,6-difluorophenyl) -4- (4-fluorophenyl) piperidine?

(1- (4- ((2R, 5R) -2,5-bis (4-A-2-B-5-cyanobenzyl) pyrrolidine-1-yl) -2,6-diethylbenzyl) -4 - (4-ethylbenzyl)) and its market prospects are as follows:

This compound may have potential applications in the field of medicinal chemistry. From a structural perspective, its complex chemical structure suggests that it may have unique biological activities. In drug development, this structure containing multiple specific substituents may be able to precisely bind to specific biological targets, thus demonstrating the potential to treat related diseases.

In terms of market prospects, if the compound is deeply researched and developed, and proves to be effective in the treatment of major diseases such as cancer and neurological diseases, the market demand is expected to be quite high. At present, many pharmaceutical companies and scientific research institutions have a strong demand for new therapeutic drugs. If this compound can stand out, it will surely attract a lot of attention and investment.

However, its marketing activities also face challenges. Drug development requires a long and expensive process. It requires a large amount of money and time to go through multiple stages of pre-clinical research and clinical trials. In addition, the competition is fierce, and new drugs in the pharmaceutical market are emerging one after another. Only with significant advantages in efficacy, safety and cost-effectiveness can it occupy market share. But overall, if it can be successfully developed, its prospects may be quite promising, promising to bring new treatment options to patients and generate lucrative economic benefits for enterprises.